George H. Rothblat, Ph.D.
George H. Rothblat, Ph.D.
Research Professor of Pediatrics
Department: Pediatrics
Contact information
The Children’s Hospital of Philadelphia
Abramson Building, Room 1102C
3615 Civic Center Blvd.
Philadelphia, PA 19104
Abramson Building, Room 1102C
3615 Civic Center Blvd.
Philadelphia, PA 19104
Office: 215-590-0585
Fax: 215-590-0583
Fax: 215-590-0583
Email:
rothblat@email.chop.edu
rothblat@email.chop.edu
Education:
B.S. (Bacteriology)
University of Connecticut, 1957.
Ph.D. (Medical Microbiology)
University of Pennsylvania, 1961.
Permanent linkB.S. (Bacteriology)
University of Connecticut, 1957.
Ph.D. (Medical Microbiology)
University of Pennsylvania, 1961.
Selected Publications
Yancey PG, Bortnick AE, Kellner-Weibel G, de la Llera-Moya M, Phillips MC, Rothblat GH.: Importance of different pathways of cellular cholesterol efflux. Arterioscler Thromb Vasc Biol 23: 712-719, 2003.Asztalos BF, de la Llera-Moya M, Dallal GE, Horvath KV, Schaefer EJ, Rothblat GH.: Differential effects of HDL subpopulations on cellular ABCA1- and SR-BI-mediated cholesterol efflux. J Lipid Res 46: 2246-2253, 2005.
Zhang Y, Da Silva JR, Reilly M, Billheimer JT, Rothblat GH, Rader DJ.: Hepatic expression of scavenger receptor class B type I (SR-BI) is a positive regulator of macrophage reverse cholesterol transport in vivo. J Clin Invest 115: 2870-2874, 2005.
Zimetti F, Weibel GK, Duong M, Rothblat GH.: Measurement of cholesterol bidirectional flux between cells and lipoproteins. J Lipid Res 47: 605-613, 2006.
Duong, PT, Collins, HL, Nickel, M, Lund-Katz, S, Rothblat, GH, Phillips, MC: Characterization of nascent HDL particles and microparticles formed by ABCA1-mediated efflux of cellular lipids to apoA-I. J Lipid Res 47: 832-843, 2006.
Duong M-N, Collins HL, Jin W, Zanotti I, Favari E, Rothblat GH: Relative contributions of ABCA1 and SR-BI to cholesterol efflux to serum from fibroblasts and macrophages. Arterioscler Thromb Vasc Biol 26: 541-547, 2006.
Adorni MP, Zimetti F, Billheimer JT, Wang N, Rader, DJ, Phillips MC, Rothblat GH: The roles of different pathways in the release of cholesterol from macrophages. J Lipid Res 48: 2453-2462, 2007.
Duong PT, Lund-Katz S, Rothblat GH, Phillips MC: Comparison of the cellular lipid efflux properties of pre-beta high-density lipoprotein and lipid-free apolipoprotein A-I. Arterioscler Thromb Vasc Biol 27: 150, 2007.
Weibel GL, Alexander ET, Joshi MR, Rader DJ, Lund-Katz S, Phillips MC, Rothblat GH: A comparative study of cellular lipid mobilizaition and efflux to human apoA-I and apoA-I Milano. Arterioscler Throm and Vasc Biol 27: 2022-2029, 2007.
Sankaranarayanan S, Oram JF, Asztalos BF, Vaughan AM, Lund-Katz S, Adorni MP, Phillips MC, Rothblat GH: Effects of acceptor composition and mechanism of ABCG1-mediated cellular free cholesterol efflux. J Lipid Res 50: 275-284, 2009.