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Hongtao Zhang, Ph.D.

Hongtao Zhang, Ph.D.

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Research Assistant Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine

Contact information
Department of Pathology / Lab Medicine
252 John Morgan Bldg
3620 Hamilton Walk
Philadelphia, PA 19104
Office: 215-573-9256
Fax: 215-898-2401
Education:
B.S. (Biochemistry)
Beijing University, China, 1991.
M.S. (Molecular Biology)
Beijing University, China, 1994.
Ph.D (Pharmacology)
University of Pennsylvania, 1998.
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Description of Research Expertise

-Targeted therapies for ErbB and related receptors (EGFR, HER2)
-Inhibitors for TNF family of receptors: TNFR, RANK etc.
-Protein engineering for antibody -like proteins
-Biomarkers to facilitate treatment for Breast cancer and Melanoma

Selected Publications

Kumar, S. M., Liu, S., Lu, H., Zhang, H., Zhang, P. J., Gimotty, P. A., Guerra, M., Guo, W., Xu, X. : Acquired cancer stem cell phenotypes through Oct4-mediated dedifferentiation. Oncogene Jan 2012 Notes: doi: 10.1038/onc.2011.656.

Song, X., Li, B., Xiao, Y., Chen, C., Wang, Q., Liu, Y., Berezov, A., Xu, C., Gao, Y., Li, Z., Wu, S., Cai, Z., Zhang, H., Karger, B., Hancock, W.H., Wells, A. D., Zhou, Z. and Greene, M.I. : Structural and Biological features of Insights of FOXP3 Dimerization Relevent to Regulatory T Cell Function. Coiled Coil Subdomain in Oligomerization-Dependent Immune Modulation. Cell reports 2012 Notes: Doi:10.1016/j.celrep.2012.04.012.

Tchou J, Wang LC, Selven B, Zhang H, Conejo-Garcia J, Borghaei H, Kalos M, Vondeheide RH, Albelda SM, June CH, Zhang PJ. : Mesothelin, a novel immunotherapy target for triple negative breast cancer. Breast Cancer Res Treat. 2012.

Lam, L., McAndrew, N., Yee, M., Fu, T., Tchou, J.C., and Zhang, H.: Challenges in the clinical utility of the serum test for HER2 ECD. Biochimica et biophysica acta 2012.

Zhou, Z., Du, X., Cai, Z., Song, X., Zhang, H., Mizuno, T., Suzuki, E., Yee, M. R., Berezov, A., Murali, R., Wu, S. L., Karger, B. L., Greene, M. I., Wang, Q.: Structure of Sad1-UNC84 Homology (SUN) Domain Defines Features of Molecular Bridge in Nuclear Envelope. The Journal of biological chemistry 287(8): 5317-26, 2012.

Zhang, H., Xiao, Y., Zhu, Z., Li, B., Greene, M. I.: Immune regulation by histone deacetylases: a focus on the alteration of FOXP3 activity. Immunol Cell Biol 90(1): 95-100, 2012.

Zhou, H., Zha, Z., Liu, Y., Zhang, H., Zhu, J., Hu, S., Cheng, L., Niu, L., Greene, M.I. , Teng, M. and Liu, J. : Structural insights into the down-regulation of overexpressed p185her2/neu of transformed cells by the antibody chA21. JBC (accepted), 2011.

Fu, W., Madan, E., Yee, M., Zhang, H.: Progress of molecular targeted therapies for prostate cancers. Biochimica et biophysica acta 1825(2): 140-152, 2011.

Zhang H, Fu T, McGettigan S, Kumar S, Liu S, Speicher D, Schuchter L, and Xu X. : IL8 and Cathepsin B as Melanoma Serum Biomarkers. Int j Mol Sci 12: 1505-1518, 2011 Notes: doi:10.3390/ijms12031505.

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Last updated: 12/13/2014
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