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Maria P. Limberis, Ph.D.

Maria P. Limberis, Ph.D.

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Research Assistant Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine

Contact information
125 South 31st street, Suite 2011, TRL
Philadelphia, PA 19103
Office: 215-898-0226
Fax: 215-494-5444
Lab: 215-898-3123
Education:
B.Sc. Hons (Biochemistry)
Liverpool John Moores University, United Kingdom, 1997.
Ph.D. (Molecular Biology)
University of Adelaide, Australia, 2003.
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Description of Research Expertise

Dr. Limberis is an expert in lung-directed gene transfer using viral-based vectors. She is developing AAV-based prophylactic vaccines for deadly airborne infectious diseases. She also investigates gene therapy for cystic fibrosis and studies the immunological implications of lung-directed gene therapy with an emphasis on cellular immune activation to therapeutic transgene products.

Selected Publications

Limberis M.P., Adam V.S., Wong G., Gren J., Kobasa D., Ross T.M., Kobinger G.P., Tretiakova A., Wilson J.M.: Intranasal antibody gene transfer in mice and ferrets elicits broad protection against pandemic influenza. Science Translational Medicine 5(187): 187ra72, May 2013.

Limberis M.P., Racine T., Kobasa D., Li Y., Gao G.F., Kobinger G., Wilson J.M.: Vectored expression of a broadly neutralizing antibody (FI6) in mouse airway provides partial protection against a new avian influenza A (H7N9) virus. Clinical and Vaccine Immunology 12(20): 1836-7, Dec 2013.

Calcedo R., Griesenbach U., Dorgan D.J., Soussi S., Boyd A.C., Davies J.C., Higgins T.E., Hyde S.C., Gill D.R., Innes J.A., Porteous D.J., Alton E.W., Wilson J.M., Limberis M.P.: Self-Reactive CFTR T Cells in Humans: Implications for Gene Therapy. Human Gene Therapy Clinical Development 24(3): 108-115, Sep 2013.

Nagai Y., Limberis M.P., Zhang H.: Modulation of Treg function improves adenovirus vector-mediated gene expression in the airway. Gene Therapy 21(2): 219-24, Feb 2014.

Davey M.G., Zoltick P.W., Todorow C.A., Limberis M.P., Hedrick H.L., Flake A.W.: Jaagsiekte sheep retrovirus pseudotyped lentiviral vector-mediated gene transfer to fetal ovine lung. Gene Therapy 2(19): 201-9, Feb 2012.

Bell C.L., Vandenberghe L.H., Bell P., Limberis M.P., Gao G.P., Van Vliet K., Agbandje-McKenna M., Wilson J.M.: The AAV9 receptor and its modification to improve in vivo lung gene transfer in mice. Journal of Clinical Investigation 121(6): 2427-2435, June 2011.

Limberis M.P., Bell C.L., Heath J., Wilson J.M.: Activation of transgene-specific T cells following lentivirus-mediated gene delivery to mouse lung. Molecular Therapy 18(1): 143-50, Jan 2010.

Limberis M.P., Vandenberghe L.H., Zhang L., Pickles R.J., Wilson J.M.: Transduction Efficiencies of Novel AAV Vectors in Mouse Airway Epithelium In Vivo and Human Ciliated Airway Epithelium In Vitro. Molecular Therapy 17(2): 294-301, Feb 2009.

Limberis M.P., Figueredo J., Calcedo R., Wilson J.M.: Activation of CFTR-specific T Cells in cystic fibrosis mice following gene transfer. Molecular Therapy 15(9): 1694-700, Sep 2007.

Limberis M.P., Wilson J.M.: Adeno-associated virus serotype 9 vectors transduce murine alveolar and nasal epithelia and can be readministered. Proceedings of the National Academy of Sciences USA 103(35): 12993-8, Aug 2006.

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Last updated: 08/20/2014
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