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Perelman School of Medicine at the University of Pennsylvania Advanced Search

M. Sean Grady, M.D.

M. Sean Grady, M.D.

faculty photo
Charles Harrison Frazier Professor of Neurosurgery
Department: Neurosurgery

Contact information
HUP - 3 Silverstein
3400 Spruce Street
clinical: 215.662.3483
administrative: 215.349.8325
Philadelphia, PA 19104
B.A. (Biology)
University of California, San Diego, 1977.
Georgetown University School of Medicine, 1981.
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Description of Research Expertise

Dr. Grady's research interests include memory dysfunction resulting from traumatic brain injury and minimally invasive neurosurgery.

Description of Clinical Expertise

Dr. Grady was appointed the Charles Harrison Frazier Professor & Chairman of the Department of Neurosurgery at the Perelman School of Medicine, University of Pennsylvania in March 1999. He received his undergraduate degree from the University of California, San Diego and medical degree from Georgetown University School of Medicine. He trained in Neurological Surgery at the University of Virginia from 1981-1987 and was a faculty member at the University of Washington from 1987-1999. He is Board Certified by the American Board of Neurological Surgeons and is a fellow of the American College of Surgeons. Dr. Grady served as the Secretary for American Board of Neurological Surgery from 2004-2008, and was appointed Chairman of the ABNS from 2008-2009. Dr. Grady served as a member of the editorial board for the Journal of Neurosurgery from 2000-2010.

Dr. Grady's clinical focus is in the area of Cranial Base Tumors, Pituitary Tumors, Meningiomas, Schwannomas, Malignant Skull Base Tumors as well as Cerebrovascular Disorders, Aneurysms, AVM's. Dr. Grady and Dr. Bert O’Malley (Chairman, Department of Otorhinolaryngology - Head and Neck Surgery) are co-directors of the Cranial Base Center. In addition, Dr. Grady performs general neurosurgery procedures for herniated discs of the back and neck.

Description of Other Expertise

Philadelphia Magazine Top Doctors 2004-2011.

Selected Publications

Macyszyn Luke, Lega Brad, Bohman Leif-Erik, Latefi Ahmad, Smith Michelle J, Malhotra Neil R, Welch William, Grady M Sean: Implementation of a Departmental Picture Archiving and Communication System (PACS): A Productivity and Cost Analysis. Neurosurgery May 2013.

Lee John Y K, Barroeta Julieta E, Newman Jason G, Chiu Alexander G, Venneti Sriram, Grady M Sean: Endoscopic endonasal resection of anterior skull base meningiomas and mucosa: implications for resection, reconstruction, and recurrence. Journal of neurological surgery. Part A, Central European neurosurgery 74(1): 12-7, Jan 2013.

Yin Terry, Lindley Timothy E, Albert Gregory W, Ahmed Raheel, Schmeiser Peter B, Grady M Sean, Howard Matthew A, Welsh Michael J: Loss of Acid sensing ion channel-1a and bicarbonate administration attenuate the severity of traumatic brain injury. PloS one 8(8): e72379, 2013.

Grady MS, Lee J, O'Malley B, Palmer J, Ramakrishnan V: Sphenoid Sinus Anatomy and Suprasellar Extension of Pituitary Tumors. Journal of Neurosurgery 2013.

Echlin Paul S, Grady M Sean, Timmons Shelly D: Concussion: pathophysiology and sequelae. Neurosurgical focus 33(6): Introduction: 1-2, Dec 2012.

Learned Kim O, Thaler Erica R, O'Malley Bert W, Grady M Sean, Loevner Laurie A: Hypoglossal nerve palsy missed and misinterpreted: the hidden skull base. Journal of computer assisted tomography 36(6): 718-24, Nov-Dec 2012.

Xiong G, Zhang L, Mojsilovic-Petrovic J, Arroyo E, Elkind J, Kundu S, Johnson B, Smith CJ, Cohen NA, Grady SM, Cohen AS: GABA and glutamate are not colocalized in mossy fiber terminals of developing rodent hippocampus. Brain Res 20(1474): 40-9, Sep 2012.

McClelland Collin M, Wolf Ronald L, Rassekh Christopher H, Blumberg Emily A, Grady M Sean, Livolsi Virginia A, Liu Grant T: Monocular vision loss and headache in a 60-year-old liver transplant patient. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 32(2): 167-71, Jun 2012.

Whitmore Robert G, Thawani Jayesh P, Grady M Sean, Levine Joshua M, Sanborn Matthew R, Stein Sherman C: Is aggressive treatment of traumatic brain injury cost-effective? Journal of neurosurgery 116(5): 1106-13, May 2012.

Selden Nathan R, Origitano Thomas C, Burchiel Kim J, Getch Christopher C, Anderson Valerie C, McCartney Shirley, Abdulrauf Saleem I, Barrow Daniel L, Ehni Bruce L, Grady M Sean, Hadjipanayis Costas G, Heilman Carl B, Popp A John, Sawaya Raymond, Schuster James M, Wu Julian K, Barbaro Nicholas M: A national fundamentals curriculum for neurosurgery PGY1 residents: the 2010 Society of Neurological Surgeons boot camp courses. Neurosurgery 70(4): 971-81; discussion 981, Apr 2012.

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Last updated: 08/19/2014
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