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Timothy J. Stalker, PhD

Timothy J. Stalker, PhD

faculty photo
Research Assistant Professor of Medicine
Department: Medicine

Contact information
809 BRB II.III
421 Curie Blvd.
Philadelphia, PA 19104
Office: 215-573-3631
Education:
BS (Biology)
Ursinus College, 1998.
PhD (Physiology)
Thomas Jefferson University, 2003.
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Selected Publications

Welsh JD, Stalker TJ, Voronov R, Muthard RW, Tomaiuolo M, Diamond SL, Brass LF.: A systems approach to hemostasis: 1. The interdependence of thrombus architecture and agonist movements in the gaps between platelets. Blood 124(11): 1808-15, Sep 11 2014.

Tomaiuolo M, Stalker TJ, Welsh JD, Diamond SL, Sinno T, Brass LF.: A systems approach to hemostasis: 2. Computational analysis of molecular transport in the thrombus microenvironment. Blood 124(11): 1816-23, Sep 11 2014.

Stalker TJ, Welsh JD, Tomaiuolo M, Wu J, Colace TV, Diamond SL, Brass LF.: A systems approach to hemostasis: 3. Thrombus consolidation regulates intrathrombus solute transport and local thrombin activity. Blood 124(11): 1824-31, Sept 11 2014.

Min S, Suzuki, A, Stalker, TJ, Zhao, L, Wang, Y, McKennan, C, Riese, M, Guzman, J, Zhang, S, Lian, L, Joshi, R, Meng, R, Seeholzer, SH, Choi, J, Koretzky, G, Marks, MS, Abrams, CS. : Loss of PIKfyve in platelets causes a lysosomal disease leading to inflammation and thrombosis in mice. Nature Communications 5: 4691, Sept 2 2014.

Stalker TJ, Welsh JD, Brass LF.: Shaping the platelet response to vascular injury. Curr Opin Hematol 21(5): 410-7, Sept 2014.

Stalker, T. J., Traxler, E. A., Wu, J., Wannemacher, K. M., Cermignano, S. L., Voronov, R., Diamond, S. L., Brass, L. F.: Hierarchical organization in the hemostatic response and its relationship to the platelet-signaling network. Blood 121(10): 1875-85, 2013.

Welsh J D, Colace T V, Muthard R W, Stalker T J, Brass L F, Diamond S L: Platelet-targeting sensor reveals thrombin gradients within blood clots forming in microfluidic assays and in mouse. Journal of thrombosis and haemostasis 10(11): 2344-53, Nov 2012.

Naik MU, Stalker TJ, Brass LF, Naik UP.: JAM-A protects from thrombosis by suppressing integrin αIIbβ3-dependent outside-in signaling in platelets. Blood 119(14): 3352-3360, April 2012.

Ma P, Cierniewska A, Signarvic R, Cieslak M, Kong H, Sinnamon AJ, Neubig RR, Newman DK, Stalker TJ, Brass LF.: A newly identified complex of spinophilin and the tyrosine phosphatase, SHP-1, modulates platelet activation by regulating G protein-dependent signaling. Blood 119(8): 1935-45, Feb 2012.

Signarvic, RS, Cierniewska, A, Stalker, TJ, Fong, KP, Chatterjee, MS, Hess, PR, Ma, PS, Diamond, SL, Neubig, RR, Brass, LF: RGS/G(i2 alpha) interactions modulate platelet accumulation and thrombus formation at sites of vascular injury. Blood 116(26): 6092-6100, DEC 23 2010.

Wannemacher, KM, Zhu, L, Jiang, H, Fong, KP, Stalker, TJ, Lee, D, Tran, AN, Neeves, KB, Maloney, S, Kumanogoh, A, Kikutani, H, Hammer, DA, Diamond, SL, Brass, LF: Diminished contact-dependent reinforcement of Syk activation underlies impaired thrombus growth in mice lacking Semaphorin 4D. Blood 116(25): 5707-5715, DEC 16 2010.

Stalker, TJ, Wu, J, Morgans, A, Traxler, EA, Wang, L, Chatterjee, MS, Lee, D, Quertermous, T, Hall, RA, Hammer, DA, Diamond, SL, Brass, LF: Endothelial cell specific adhesion molecule (ESAM) localizes to platelet-platelet contacts and regulates thrombus formation in vivo. Journal of Thrombosis and Haemostasis 7(11): 1886-1896, NOV 2009.

Zhu, L, Stalker, TJ, Fong, KP, Jiang, H, Tran, A, Crichton, I, Lee, EK, Neeves, KB, Maloney, SF, Kikutani, H, Kumanogoh, A, Pure, E, Diamond, SL, Brass, LF: Disruption of SEMA4D Ameliorates Platelet Hypersensitivity in Dyslipidemia and Confers Protection Against the Development of Atherosclerosis. Arteriosclerosis Thrombosis and Vascular Biology 29(7): 1039-U106, JUL 2009.

Wang, YF, Chen, XS, Lian, LR, Tang, T, Stalker, TJ, Sasaki, T, Brass, LF, Choi, JK, Hartwig, JH, Abrams, CS: Loss of PIP5KI beta demonstrates that PIP5KI isoform-specific PIP2 synthesis is required for IP3 formation. Proceedings of the National Academy of Sciences of the United States of America 105(37): 14064-14069, SEP 16 2008.

Zhu, L, Bergmeier, W, Wu, J, Jiang, H, Stalker, TJ, Cieslak, M, Fan, R, Boumsell, L, Kumanogoh, A, Kikutani, H, Tamagnone, L, Wagner, DD, Milla, ME, Brass, LF: Regulated surface expression and shedding support a dual role for semaphorin 4D in platelet responses to vascular injury. Proceedings of the National Academy of Sciences of the United States of America 104(5): 1621-1626, JAN 30 2007.

Prevost, N, Woulfe, DS, Jiang, H, Stalker, TJ, Marchese, P, Ruggeri, ZM, Brass, LF: Eph kinases and ephrins support thrombus growth and stability by regulating integrin outside-in signaling in platelets. Proceedings of the National Academy of Sciences of the United States of America 102(28): 9820-9825, JUL 12 2005.

Stalker TJ, Gong YL, Scalia R: The calcium-dependent protease calpain causes endothelial dysfunction in type 2 diabetes. Diabetes 54(4): 1132-1140, APR 2005.

Stalker, TJ, Skvarka, CB, Scalia, R: A novel role for calpains in the endothelial dysfunction of hyperglycemia. Faseb Journal 17(9): 1511, JUN 2003.

Schmaier AA, Stalker TJ, Runge JJ, Lee D, Nagaswami C, Mericko P, Chen M, Cliche S, Gariépy C, Brass LF, Hammer DA, Weisel JW, Rosenthal K, Kahn ML.: Occlusive thrombi arise in mammals but not birds in response to arterial injury: evolutionary insight into human cardiovascular disease. Blood 118(13): 3661-3669, Sept 2011.

Brass Lawrence F, Tomaiuolo Maurizio, Stalker Timothy J: Harnessing the platelet signaling network to produce an optimal hemostatic response. Hematology/oncology clinics of North America 27(3): 381-409, Jun 2013.

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Last updated: 10/03/2014
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