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Joshua R Friedman, MD, PhD

Joshua R Friedman, MD, PhD

faculty photo
Associate Professor of Pediatrics
Department: Pediatrics

Contact information
20 Llanfair Circle
Ardmore, PA 19003
Education:
AB (Biochemistry)
Harvard University, 1991.
PhD (Cell and Molecular Biology)
University of Pennsylvania, 1996.
MD
University of Pennsylvania, 1998.
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Description of Research Expertise

Research Interests
My laboratory conducts basic and translational research on microRNA in pediatric gastrointestinal and liver development and disease.

Keywords
Liver development, microRNA, biliary atresia, cholestasis, fibrosis, inflammatory bowel disease, eosinophilic esophagitis.

Research details
1) MicroRNA in biliary atresia
Goal: to determine if microRNA plays a functional role in biliary atresia, using clinical samples, a mouse model of the disease, and cell culture tools.

2) MicroRNA in cholestatic liver disease
Goal: to understand how microRNA promotes the adaptive response to cholestasis.

3) MicroRNA in liver development
Goal: to determine if miRNA functions in liver development, particularly biliary specification and morphogenesis.

4) MicroRNA as a biomarker for gastrointestinal and liver disease.
Goal: to utilize circulating and tissue miRNA levels as diagnostic and prognostic biomarkers for diseases such as biliary atresia, inflammatory bowel disease, and eosinophilic esophagitis.

Rotation projects
MicroRNA target identification (several relevant miRNAs available)
Genetic models of specific miRNA deficiency
Functional analysis of miRNA in a cell culture model of biliary differentiation

Lab personnel
Nick Hand, Scientist
Adam Zahm, Post-doctoral Fellow
Claire Le Guen, Technician
Scott Gordon, MD/PhD student (post-PhD)

Description of Clinical Expertise

Pediatric Gastroenterology and Hepatology
BIliary atresia
Cholestatic liver disease
Inflammatory bowel disease
Eosinophilic esophagitis

Selected Publications

Kameswaran V, Bramswig NC, McKenna LB, Penn M, Schug J, Hand NJ, Chen Y, Won K-J, Vourekas A, Choi I, Liu C, Vivek K, Naji A, Friedman JR, Kaestner KH: Epigenetic regulation of the MEG3-DLK1 microRNA cluster in human Type 2 diabetic islets. Cell Metabolism 19(1): 135-45, Jan 2014.

Zahm AM, Hand NJ, Tsoucas DM, Le Guen CL, Baldassano RN, Friedman JR: Rectal microRNAs are perturbed in pediatric inflammatory bowel disease of the colon. Journal of Crohn's and Colitis in press, 2014.

Le Guen CL, Friedman JR, Hand NJ: Novel targets of miR-30, a microRNA required for biliary development. F1000Research 2: 197, October 2013.

Karjoo S, Hand NJ, Loarca L, Russo PA, Friedman JR, Wells RG: Extra-hepatic cholangiocyte cilia are abnormal in biliary atresia Journal of Pediatric Gastroenterology and Nutrition 57(1): 96-101, April 2013 Notes: Epub ahead of print.

Schug J, McKenna LB, Walton G, Hand N, Mukherjee S, Essuman K, Shi Z, Gao Y, Markley K, Nakagawa M, Kameswaran V, Vourekas A, Friedman JR, Kaestner KH, Greenbaum LE: Dynamic Recruitment of microRNAs to their mRNA Targets in the Regenerating liver. BMC Genomics 14(1): 264, April 2013.

Zahm, AM, Hand, NJ, Boateng, LA, Friedman, JR: Circulating MicroRNA is a Biomarker of Biliary Atresia. Journal of Pediatric Gastroenterology and Nutrition 55(4): 366-9, October 2012.

Venneti S, Boateng LA, Friedman JR, Baldwin DA, Tobias JW, Judkins AR, Mourelatos Z, Lal P: MiRNA-9 and miRNA-200a distinguish hemangioblastomas from metastatic clear cell renal cell carcinomas in the CNS. Brain Pathology 22(4): 522-529, July 2012.

Sonnenberg GF, Monticelli LA, Alenghat T, Fung TC, Hutnick NA, Kunisawa J, Shibata N, Grunberg S, Sinha R, Zahm AM, Sathaliyawala T, Kubota M, Farber DL, Collman RG, Shaked A, Fouser LA, Weiner DB, Tessier PA, Friedman JR, Kiyono H, Bushman FD, Chang K-M, Artis D: Innate lymphoid cells orchestrate anatomical containment of lymphoid-resident commensal bacteria and prevent systemic immune activation. Science 336(6086): 1321-1325, June 2012.

Hand NJ, Horner AM, Master ZR, Boateng LA, LeGuen C, Uvaydova M, Friedman JR: MicroRNA profiling identifies miR-29 as a regulator of disease-associated pathways in experimental biliary atresia. Journal of Pediatric Gastroenterology and Nutrition 54(2): 186-192, February 2012.

Zahm AM, Thayu M, Hand NJ, Horner A, Leonard MB, Friedman JR: Circulating microRNA is a biomarker of pediatric Crohn disease. Journal of Pediatric Gastroenterology and Nutrition 53(1): 26-33, July 2011.

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Last updated: 12/17/2014
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