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Rita J. Balice-Gordon, Ph.D.

Rita J. Balice-Gordon, Ph.D.

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Adjunct Professor of Neuroscience
Department: Neuroscience

Contact information
Department of Neuroscience
University of Pennsylvania School of Medicine
Philadelphia, PA 19104-6074
Education:
B.A. (Biological Sciences)
Northwestern University, 1982.
Graduate (Neurobiology)
University of Chicago, 1984.
Ph.D. (Neurobiology)
University of Texas at Austin, 1987.
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Description of Research Expertise

RESEARCH INTERESTS
My lab studies the cellular and molecular interactions among neurons, their targets and the surrounding glia that mediate and modulate synapse formation and function during neural development. We use neuromuscular synapses between motor neurons and muscle fibers in mice and zebrafish, and CNS synapses among hippocampal neurons in mice and rats in vitro and in vivo, as relatively simple, accessible and easily manipulated model systems. We use imaging, genetic, cellular, molecular and electrophysiological approaches in our research projects.

In collaboration with Josep Dalmau, M.D., Ph.D., and his lab, we are studying autoimmune disorders that selectively, and reversibly, affect CNS synapses. In these disorders, patient antibodies to synaptic proteins affect synapse structure and function, in turn affecting circuit function, leading to psychosis, disorders of learning and memory and other behavioral abnormalities. We are studying how patient antibodies lead to changes in synapses, circuits and behavior, in vitro as well as in animal models of these human diseases.

The overall goal of our work is to understand the rules by which the neural circuits that underlie particular behaviors become synaptically connected during neural development, what governs the plasticity of these circuits, what goes wrong with these circuits in neurodevelopmental, neurodegenerative and other disorders, and how we might design and implement effective therapeutic strategies.

Selected Publications

Lancaster Eric, Lai Meizan, Peng Xiaoyu, Hughes Ethan, Constantinescu Radu, Raizer Jeffrey, Friedman Daniel, Skeen Mark B, Grisold Wolfgang, Kimura Akio, Ohta Kouichi, Iizuka Takahiro, Guzman Miguel, Graus Francesc, Moss Stephen J, Balice-Gordon Rita, Dalmau Josep: Antibodies to the GABA(B) receptor in limbic encephalitis with seizures: case series and characterisation of the antigen. Lancet neurology 9(1): 67-76, Jan 2010.

Hughes Ethan G, Elmariah Sarina B, Balice-Gordon Rita J: Astrocyte secreted proteins selectively increase hippocampal GABAergic axon length, branching, and synaptogenesis. Molecular and cellular neurosciences 43(1): 136-45, Jan 2010.

Moscato, E., Jain, A., Peng, X., Hughes, E. G., Dalmau, J. and Balice-Gordon, R. J. : Mechanisms of synaptic autoimmunity in disorders of memory, psychosis and cognition. Eur. J. Neuroscience. P. Scheiffele (eds.). Elsevier, 2010.

Hughes EG, Peng X, Gleichman AJ, Lai M, Zhou L, Tsou R, Parsons TD, Lynch DR, Dalmau J, Balice-Gordon RJ: Cellular and synaptic mechanisms of anti-NMDA receptor encephalitis. J. Neuroscience 2010.

Lai Meizan, Hughes Ethan G, Peng Xiaoyu, Zhou Lei, Gleichman Amy J, Shu Huidy, Matà Sabrina, Kremens Daniel, Vitaliani Roberta, Geschwind Michael D, Bataller Luis, Kalb Robert G, Davis Rebecca, Graus Francesc, Lynch David R, Balice-Gordon Rita, Dalmau Josep: AMPA receptor antibodies in limbic encephalitis alter synaptic receptor location. Annals of neurology 65(4): 424-34, Apr 2009.

Keene Sarah Dunn, Greco Todd M, Parastatidis Ioannis, Lee Seon-Hwa, Hughes Ethan G, Balice-Gordon Rita J, Speicher David W, Ischiropoulos Harry: Mass spectrometric and computational analysis of cytokine-induced alterations in the astrocyte secretome. Proteomics 9(3): 768-82, Feb 2009.

Song Yuanquan, Selak Mary A, Watson Corey T, Coutts Christopher, Scherer Paul C, Panzer Jessica A, Gibbs Sarah, Scott Marion O, Willer Gregory, Gregg Ronald G, Ali Declan W, Bennett Michael J, Balice-Gordon Rita J: Mechanisms underlying metabolic and neural defects in zebrafish and human multiple acyl-CoA dehydrogenase deficiency (MADD). PloS one 4(12): e8329, 2009.

Wyatt, Ryan M. Balice-Gordon, Rita J.: Heterogeneity in synaptic vesicle release at neuromuscular synapses of mice expressing synaptopHluorin. Journal of Neuroscience 28(1): 325-35, Jan 2 2008.

Personius, Kirkwood E. Chang, Qiang. Mentis, George Z. O'Donovan, Michael J. Balice-Gordon, Rita J.: Reduced gap junctional coupling leads to uncorrelated motor neuron firing and precocious neuromuscular synapse elimination. Proceedings of the National Academy of Sciences of the United States of America 104(28): 11808-13, Jul 10 2007.

Panzer, Jessica A. Song, Yuanquan. Balice-Gordon, Rita J.: In vivo imaging of preferential motor axon outgrowth to and synaptogenesis at prepatterned acetylcholine receptor clusters in embryonic zebrafish skeletal muscle. Journal of Neuroscience 26(3): 934-47, Jan 18 2006.

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Last updated: 06/06/2014
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