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Raymond Stephen Roginski, MD, PhD

Raymond Stephen Roginski, MD, PhD

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Clinical Assistant Professor of Anesthesiology and Critical Care
Department: Anesthesiology and Critical Care

Contact information
Department of Anesthesiology and Critical Care
Philadelphia Veterans Administration Medical Center
3900 Woodland Avenue
Philadelphia, PA 19104
Office: 215-823-5800 x5418
Fax: 215-823-4171
Lab: 215-823-5800 x3970
Education:
BS (Molecular Biophysics and Biochemistry)
Yale University, 1977.
MS (Molecular Biophysics and Biochemistry)
Yale University, 1977.
MS (Cell Biology Department)
Sue Golding Graduate Division, Albert Einstein College of Medicine of Yeshiva University, 1981.
MD (Medicine)
Albert Einstein College of Medicine, 1985.
PhD (Cell Biology Department)
Sue Golding Graduate Division, Albert Einstein College of Medicine of Yeshiva University, 1985.
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Description of Research Expertise

Research on NMDA receptors and GRINL1A interactions has really come to fruition over the past three years. My lab and others around the world have found disease-related roles of GRINL1A (now known by the gene symbol GCOM1) and GRINL1B/GCOM2 genes and proteins, e.g., the Gdown1 protein has been identified as 13th RNA polymerase II subunit; Gup1 is a.k.a. Myozap, a component of the cardiac muscle intercalated disk with a role in a form of cardiomyopathy; the GRINL1B gene was shown to be mutated in acute myeloid leukemia and many other reports such that the total bibliography now exceeds 20 peer reviewed articles. Links to many neuro-psychiatric diseases have been discovered as a result of my lab's yeast two-hybrid (Y2H) screens that revealed 27 new genes that interact with the C- and N-terminal segments of the GRINL1A Gcom1 protein. Therefore, the Y2H studies have firmly connected GCOM1 to glutamatergic neurotransmission and transcription (see publications in Molecular Cell, January 2012). Collaborations continue and are flourishing, especially: Jay Yang (U of Wisconsin) and Patricia Soteropoulos (Bioinformatics at UMDNJ-Rutgers in New Jersey).

Distinction: Earlier in my career I co-authored papers in Cell, Molecular and Cellular Biology and Proceedings of the National Academy of Sciences of the USA with Oliver Smithies (and others). In October 2007, Dr. Smithies (and two other scientists) received the Nobel Prize in Physiology or Medicine for his discovery of principles for introducing specific gene modifications into mice using embryonic stem cells.

My Education activities in 2007-2008 added Simulation. I took the Wiser programming course to leqarn how to devise and run scenarios and became part of Dept Sim group. I have done several Sim session with Residents.

Academic: manuscript on the Gcom1-NR1 interaction and inhibition of NMDA toxicity in rat primary cortical neuronal cultures was published in 2008 in NeuroReport. I have a first author manuscript on the interaction of GCOM1 with the NMDA receptor and internexin-alpha in preparation which should be submitted to Genomics in January 2015. I have been invited to speak at SUNY Buffalo in April 2015.

Description of Clinical Expertise

Off-site (out-of-OR) anesthesiology. Anesthesia for spine surgery. Use of newer monitors such as ForeSite and NexFin. Use of ultrasound (e.g., Sonosite) for US guided regional anesthesia. Attended regional anesthsia workshop at 2014 American Society of Anesthesiologists Annual Meeting in New Orleans, LA.
Statistics: Attended Dr Jeffrey Gross' workshop at 2014 ASA Annual Mtg in New Orleans, LA.
Difficult airway management: courses at ASA Annual meeting and MD Anderson Cancer Center plus routine use of Glidescope and Fiberoptic methods at the Philadelphia VA medical center. Joined the Society for Airway Management in 2013 and attended their annual meeting in Philadelphia, PA.

Description of Other Expertise

Research training, teaching and mentoring of undergraduate, graduate and medical students, PhD and MD PhD candidates, residents and post-doctoral fellows, at least 25 since the end of my residency (1989) in molecular biology, molecular genetics and genomics. DNA, RNA and protein analysis methods such as Southern blots, Northern blots, Western blots, PCR etc

Selected Publications

Roginski R, Du P, Soteropoulos P, Santoiemma P: Bioinformatic and Structural Analyses of GCOM1 and its Interacting Genes Suggest New Functions. Journal of Neurosurgical Anesthesiology Event: Society for Neuroscience in Anesthesiology and Critical Care 42nd Annual Meeting, New Orleans, LA, October 9-10, 2014 26(4): 474, October 2014.

Roginski RS, Weaver SJ, Santoiemma PP, Yang J: NMDA Receptor Interacts with GCOM1 and Internexin-alpha. American Society of Anesthesiologists Annual Meeting, San Francisco, CA, A1144, October 12-16, 2013. October 2013.

Pierwola K, Iascone D, Talbot K, Roginski RS: Decreased Expression of GCOM1 and NMDARs in Alzheimer Disease Is Consistent with a Role in Neuroprotection. Journal of Neurosurgical Anesthesiology Event: Society for Neuroscience in Anesthesiology and Critical Care 40th Annual Meeting, Washington, DC, October 11-12, 2012 24(4): 447, October 2012 Notes: Presented as a walk-around poster discussion format on October 12, 2012 at the Society for Neuroscience in Anesthesiology and Critical Care 40th Annual Meeting.

Roginski RS, Iascone DM, Heo K, Yang J: GCOM1-Internexin-alpha Y2H Interaction Confirmed in Rat Brain Suggests Novel NMDA Receptor-Initiated Pathway. Journal of Neurosurgical Anesthesiology, SNACC 39th Annual Meeting, Chicago Illinois, 13-14 October 2011. Wolters Kluwer LWW, 23(4): 450-451, October 2011 Notes: Abstract A119.

Roginski RS, Santoiemma PP, Yang J, Kawakami T: Large GCOM1 Protein Implicated in Neuroprotection Interacts with NR1 Subunit of NMDA Receptor. ASA Annual Meeting, San Diego, California(A1521), October 2010.

Roginski RS, Santoiemma PP, Yang J: Large GCOM1 Protein Implicated in Neuroprotection Interacts with NR1 Subunit of NMDA Receptor. Journal of Neurosurgical Anesthesiology, SNACC 38th Annual Meeting, San Diego, California 22(4): 404-405, October 2010.

Roginski RS, Santoiemma PP: GCOM1 Is a Hub Gene with Links to Neuroprotection, Cancer, CNS Diseases, NMDARs and Gene Regulation. ASA Annual Meeting, New Orleans, Louisiana 2009(A945), October 2009.

Roginski RS, Santoiemma PP: GCOM1 Is a Hub Gene with Links to Neuroprotection, Cancer, CNS Diseases, NMDARs and Gene Regulation. Journal of Neurosurgical Anesthesiology 21(4): 399-400, October 2009.

Roginski RS, Goubaeva F, Mikami M, Fried-Cassorla E, Nair MR, Yang J: GRINL1A colocalizes with N-methyl D-aspartate receptor NR1 subunit and reduces N-methyl D-aspartate toxicity. NeuroReport. Lippincott Williams and Wilkins, 19(17): 1721-1726, November 2008 Notes: Epub ahead of print 9 October 2008.

Santoiemma P, Roginski RS: GRINL1A Interacting Proteins Reveal Links to Neurologic Diseases, Synaptic Function and Transcription Regulation. J Neurosurg Anesthesiol. Cottrell JE (eds.). Wolters Kluwer/Lippincott Williams & Wilkins, 20(4): 316, October 2008 Notes: Presented at: Society of Neurosurgical Anesthesiology and Critical Care 36th Annual Meeting, Orlando, FL, October 17, 2008.

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Last updated: 12/17/2014
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