Avinash Bhandoola, M.B., B.S., Ph.D.
Avinash Bhandoola, M.B., B.S., Ph.D.
Associate Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine
Graduate Group Affiliations
Contact information
266 John Morgan Building
3620 Hamilton Walk
Philadelphia, PA 19104
3620 Hamilton Walk
Philadelphia, PA 19104
Office: (215) 573-0274
Fax: (215) 573-2350
Fax: (215) 573-2350
Email:
bhandooa@mail.med.upenn.edu
bhandooa@mail.med.upenn.edu
Publications
Education:
M.B., B.S. (Medicine)
Grant Medical College, Bombay, India, 1986.
Ph.D. (Immunology)
University of Pennsylvania (1988-1994), 1994.
Permanent linkM.B., B.S. (Medicine)
Grant Medical College, Bombay, India, 1986.
Ph.D. (Immunology)
University of Pennsylvania (1988-1994), 1994.
Description of Research Expertise
Research Interests :We're interested in the mechanisms by which some hematopoietic progenitor cells migrate to the thymus, as well as the transcriptional mechanisms in the thymus that direct the earliest thymus colonizing progenitors down the T cell lineage.
Current projects in the laboratory include:
(1) Signals that permit circulating hematopoietic progenitors to selectively settle within the thymus from the blood, and how these signals change during thymic regeneration. Zlotoff, Zhang, et al., Blood, 2011; Zlotoff et al., Blood, 2010)
(2) Transcription factors that establish and maintain T-cell specific gene expression. (Sambandam et al., Nature Immunology, 2005; Weber, Chi, et al., Nature, 2011).
(3) The development and function of newly described T-cell like cells termed Natural Helper cells (Yang et al., J Immunol, 2011).
Lab Personnel:
Maria Elena De Obaldia
Qi Yang
Brittany Weber
Shirley Zhang
Avinash Bhandoola
Selected Publications
Yang Q, Saenz S, Zlotoff DA, Artis D, Bhandoola A: Cutting Edge: Natural helper cells derive from lymphoid progenitors. J Immunol. October 2011. Notes: [Epub ahead of print: October 24, 2011]Chi AW, Chavez A, Xu L, Weber BN, Shestova O, Shaffer A, Wertheim G, Pear WS, Izon D, Bhandoola A: Identification of Flt3+CD150- myeloid progenitors in adult mouse bone marrow that harbor T lymphoid developmental potential. Blood 118(10), September 2011. Notes: [Epub ahead of print: July 26, 2011]
Zlotoff DA, Zhang SL, De Obaldia ME, Hess PE, Todd SP, Logan TD, Bhandoola A : Delivery of progenitors to the thymus limits T-lineage reconstitution after bone marrow transplantation. Blood 118(7): 1962-70, June 2011. Notes: [Epub ahead of print: June 9, 2011]
Weber BN, Chi AW, Chavez A, Yashiro-Ohtani Y, Yang Q, Shestova O, Bhandoola A: A critical role for TCF-1 in T-lineage specification and differentiation. Nature 476(7358): 63-8, August 2011.
Love PE, Bhandoola A: Signal integration and crosstalk during thymocyte migration and emigration. Nat Rev Immunol. 11(7): 469-77, June 2011.
Uhmann A, van den Brandt J, Dittmann K, Heß I, Dressel R, Binder C, Lühder F, Christiansen H, Fassnacht M, Bhandoola A, Wienands J, Reichardt HM, Hahn H: T cell development critically depends on prethymic stromal patched expression J Immunol. 186(6): 3383-3391, March 2011.
Zlotoff DA, Bhandoola A: Hematopoietic progenitor migration to the adult thymus. Ann NY Acad Sci. 1217(1): 122-38, January 2011.
Agosto LM, Liszewski MK, Mexas A, Graf E, Pace M, Yu JJ, Bhandoola A, O'Doherty U: Patients on HAART often have an excess of unintegrated HIV DNA: Implications for monitoring reservoirs. Virology 409(1): 46-53, January 2011.
Sultana DA, Bell JJ, Zlotoff DA, DeObaldia ME, Bhandoola A: Eliciting the T cell fate with Notch. Semin Immunol. 22(5): 254-60, October 2010. Notes: [Epub ahead of print: June 2, 2010]
Liu H, Chi AW, Arnett KL, Chiang MY, Xu L, Shestova O, Wang H, Li YM, Bhandoola A, Aster JC, Blacklow SC, Pear WS: Notch dimerization is required for leukemogenesis and T-cell development. Genes Dev. 24(21), October 2010. Notes: [Epub ahead of print: October 8, 2010]