Avinash Bhandoola, MBBS, PhD
Avinash Bhandoola, MBBS, PhD
Associate Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine
Graduate Group Affiliations
Contact information
266 John Morgan Building
3620 Hamilton Walk
Philadelphia, PA 19104
3620 Hamilton Walk
Philadelphia, PA 19104
Office: (215) 573-0274
Fax: (215) 573-2350
Fax: (215) 573-2350
Email:
bhandooa@mail.med.upenn.edu
bhandooa@mail.med.upenn.edu
Publications
Education:
M.B., B.S. (Medicine)
Grant Medical College, Bombay, India, 1986.
Ph.D. (Immunology)
University of Pennsylvania (1988-1994), 1994.
Permanent linkM.B., B.S. (Medicine)
Grant Medical College, Bombay, India, 1986.
Ph.D. (Immunology)
University of Pennsylvania (1988-1994), 1994.
Description of Research Expertise
Research Interests :We're chiefly interested in the steps linking hematopoietic stem cells to the earliest T lineage progenitors in the thymus. We're also interested in models of T cell aging and cancer, using the information we gain from studying normal development.
Current projects in the laboratory include:
(1) Prethymic developmental steps in the bone marrow that are important for generating efficient T cell progenitors.
(2) Signals that allow hematopoietic progenitors to leave the bone marrow, gain access to the circulation and potentially the thymus.
(3) Signals that permit circulating hematopoietic progenitors to selectively settle within the thymus from the blood.
(4) Early intrathymic differentiation of hematopoietic progenitors that colonize thymus from blood.
(5) Models of thymic aging.
Selected Publications
Maillard I, Koch U, Dumortier A, Shestova O, Xu L, Sai H, Pross SE, Aster JC, Bhandoola A, Radtke F, Pear WS.: Canonical notch signaling is dispensable for the maintenance of adult hematopoietic stem cells. Cell Stem Cell 2(4): 356, Apr 2008.J. Jeremiah Bell and Avinash Bhandoola: The earliest thymic progenitors for T cells possess myeloid lineage potential. Nature 452: 764, Apr 2008.
Schwarz BA, Sambandam A, Maillard I,Harman BC, Love PE & Bhandoola A: Selective Thymus Settling Regulated by Cytokine and Chemokine Receptors J. Immunol. 178: 2008-17, 2007.
Zediak V., Maillard I.M., Bhandoola A.: Multiple prethymic defects underlie age-related loss of T progenitor competence. Blood 110(4): 1161-1167, 2007.
Avinash Bhandoola, Harald von Boehmer, Howard T. Petrie and Juan-Carlos Zuniga-Pflucker: Commitment and developmental potential of extrathymic and intrathymic T cell precursors: plenty to choose from. Immunity 26: 678-89, 2007.
Zediak, V.P., I. Maillard and A. Bhandoola: Closer to the source: Notch and the nature of thymus settling cells. Immunity 23: 245-248, 2005.
Sambandam, A., Maillard, I., Zediak, V. P., Xu, L., Gerstein, R. M., Aster, J. C., Pear, W. S. and A. Bhandoola: Notch signaling controls the generation and differentiation of early T lineage progenitors. Nat Immunol 6: 663-670, 2005.
Schwarz, B.A. and A. Bhandoola: Circulating hematopoietic progenitors with T lineage potential. Nat Immunol 5: 953-960, 2004.
Allman, D., A. Sambandam, S. Kim, J.P. Miller, A. Pagan, D. Well, A. Meraz, and A. Bhandoola: Thymopoiesis independent of common lymphoid progenitors. Nat Immunol 4: 168-74, 2003.
Bhandoola, A., A. Sambandam, D. Allman, A. Meraz, and B. Schwarz: Early T lineage progenitors: new insights, but old questions remain. J. Immunol 171: 5653-5658, 2003.