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Lili Wang, Ph.D.

Lili Wang, Ph.D.

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Research Assistant Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine

Contact information
125 S. 31st Street
Suite 2000
Philadelphia, PA 19104
Office: 215-746-8929
Fax: 215-494-5443
Education:
B.S. (Biology)
Fudan University, Shanghai, China, 1986.
PhD (Microbiology & Molecular Genetics)
Rutgers University & Robert Wood Johnson Medical School, New Brunswick, New Jersey , 1996.
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Description of Research Expertise

Viral vectors, gene therapy, immune response, metabolic diseases and animal models

Selected Publications

Mays LE, Wang L, Lin J, Bell P, Crawford A, Wherry EJ, Wilson JM.: AAV8 induces tolerance in murine muscle as a result of poor APC transduction, T cell exhaustion and minimal MHCI upregulation on target cells. Molecular Therapy 22(1): 28-41, January 2014.

Wang L, Wang H, Bell P, McMenamin D, and Wilson JM. : Hepatic Gene Transfer in Neonatal Mouse by AAV8 Vector. Human Gene Therapy 23(5): 533-9, May 2012.

Wang L*, Wang H*, Morizono H, Bell P, Jones D, Lin J, McMenamin D, Yu H, Batshaw ML, and Wilson JM. (Authors contributed equally): Sustained Correction of OTC Deficiency in Spf ash Mice Using Optimized Self-complementary AAV2/8 Vectors. Gene Therapy 19(4): 404-10, April 2012 Notes: (*authors contributed equally).

Wang L, Morizono H, Lin J, Bell P, Jones D, McMenamin D, Yu H, Batshaw ML, and Wilson JM. : Preclinical Evaluation of a Clinical Candidate AAV8 Vector for Ornithine Transcarbamylase (OTC) Deficiency Reveals Functional Enzyme from Each Persisting Vector Genome. Molecular Genetics and Metabolism 105(2): 203-211, February 2012.

Wang L, Calcedo R, Bell P, Lin J, Grant R, Siegel DL, and Wilson JM. : Impact of Pre-existing Immunity on Gene Transfer to Nonhuman Primate Liver with Adeno-associated Virus 8 Vectors Human Gene Therapy 22(11): 1389-1401, November 2011.

Wang L, Bell P, Lin J, Calcedo R, Tarantal AF, and Wilson JM: AAV8-mediated Hepatic Gene Transfer in Infant Rhesus Monkeys (Macacca mulatta). Molecular Therapy 19(11): 2012-2020, November 2011.

Bell P, Wang L, Gao G, Haskins ME, Zhu Y, Yu H, McCarter RJ, and Wilson JM: Inverse Zonation of Hepatocyte Transduction with AAV Vectors Between Mice and Non-human Primates. Molecular Genetics and Metabolism 104(3): 395-403, November 2011.

Wang L, Louboutin JP, Bell P, Greig J, Li Y, Wu D, and Wilson JM: Muscle-directed Gene Therapy for Hemophilia B with More Efficient and Less Immunogenic AAV Vectors. Journal of Thrombosis and Haemostasis 9(10): 2009-19, October 2011.

Wang L*, Wang H*, Bell P, McCarter RJ, He J, Calcedo R, Vandenberghe LH, Morizono H, Batshaw ML, and Wilson JM: Systematic Evaluation of AAV Vectors for Liver-directed Gene Transfer in Murine Models. Molecular Therapy 18(1): 118-125, January 2010 Notes: (*authors contributed equally).

Wang L, Calcedo R, Wang H, Bell P, Grant R, Vandenberghe LH, Sanmiguel J, Morizono H, Batshaw ML, and Wilson JM: The Pleiotropic Effects of Natural AAV Infections on Liver-directed Gene Transfer in Macaques. Molecular Therapy 18(1): 126-134, January 2010.

Wang L, Figueredo J, Calcedo R, Lin J, and Wilson JM: Cross-presentation of adeno-associated virus serotype 2 capsids activates cytotoxic T cells but does not render hepatocytes effective cytolytic targets. Human Gene Therapy 18(3): 185-94, March 2007.

Vandenberghe LH*, Wang L*, Somanathan S, Zhi Y, Figueredo J, Calcedo R, Sanmiguel J, Desai RA, Chen CS, Johnston J, Grant RL, Gao G, and Wilson JM: Heparin binding directs activation of T cells against adeno-associated virus serotype 2 capsid. Nature Medicine 12(8): 967-71, Aug 2006 Notes: (*authors contributed equally).

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Last updated: 03/24/2014
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