Lili Wang, Ph.D.
Lili Wang, Ph.D.
Research Assistant Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine
Contact information
125 S. 31st Street
Suite 2000
Philadelphia, PA 19104
Suite 2000
Philadelphia, PA 19104
Office: 215-746-8929
Fax: 215-573-7414
Fax: 215-573-7414
Email:
liliwang@mail.med.upenn.edu
liliwang@mail.med.upenn.edu
Education:
B.S. (Biology)
Fudan University, Shanghai, China, 1986.
PhD (Microbiology & Molecular Genetics)
Rutgers University & Robert Wood Johnson Medical School, New Brunswick, New Jersey , 1996.
Permanent linkB.S. (Biology)
Fudan University, Shanghai, China, 1986.
PhD (Microbiology & Molecular Genetics)
Rutgers University & Robert Wood Johnson Medical School, New Brunswick, New Jersey , 1996.
Description of Research Expertise
Viral vectors, gene therapy, immune response, metabolic diseases and animal modelsSelected Publications
Wang L, Morizono H, Lin J, Bell P, Jones D, McMenamin D, Yu H, Batshaw ML, and Wilson JM. : Preclinical Evaluation of a Clinical Candidate AAV8 Vector for Ornithine Transcarbamylase (OTC) Deficiency Reveals Functional Enzyme from Each Persisting Vector Genome. Molecular Genetics and Metabolism 105(2): 203-211, February 2012.Wang L, Wang H, Bell P, McMenamin D, and Wilson JM. : Hepatic Gene Transfer in Neonatal Mouse by AAV8 Vector. Human Gene Therapy In press 2012.
Wang L*, Wang H*, Morizono H, Bell P, Jones D, Lin J, McMenamin D, Yu H, Batshaw ML, and Wilson JM. (Authors contributed equally): Sustained Correction of OTC Deficiency in Spf ash mice Using Optimized Self-complementary AAV2/8 Vectors. Gene Therapy In press 2012.
Wang L, Calcedo R, Bell P, Lin J, Grant R, Siegel DL, and Wilson JM. : Impact of Pre-existing Immunity on Gene Transfer to Nonhuman Primate Liver with Adeno-associated Viruse 8 Vectors Human Gene Therapy 22(11): 1389-1401, November 2011.
Wang L, Bell P, Lin J, Calcedo R, Tarantal AF, and Wilson JM: AAV8-mediated Hepatic Gene Transfer in Infant Rhesus Monkeys (Macacca mulatta). Molecular Therapy 19(11): 2012-2020, November 2011.
Bell P, Wang L, Gao G, Haskins ME, Zhu Y, Yu H, McCarter RJ, and Wilson JM: Inverse Zonation of Hepatocyte Transduction with AAV Vectors Between Mice and Non-human Primates. Molecular Genetics and Metabolism 104(3): 395-403, November 2011.
Wang L, Louboutin JP, Bell P, Greig J, Li Y, Wu D, and Wilson JM: Muscle-directed Gene Therapy for Hemophilia B with More Efficient and Less Immunogenic AAV Vectors. Journal of Thrombosis and Haemostasis 9(10): 2009-19, October 2011.
Calcedo R, Morizono H, Wang L, McCarter RJ, Batshaw ML, and Wilson JM: Adeno-associated Virus Antibody Profiles in Newborns, Children and Adolescents. Clinical and Vaccine Immunology 18(9): 1586-8, September 2011.
Bell P, Gao G, Haskins ME, Wang L, Sleeper MM, Wang H, Calcedo R, Vandenberghe LH, Chen SJ, Weisse C, Withnall E, and Wilson JM : Evaluation of AAV Vectors for Liver-directed Gene Transfer in Dogs. Human Gene Therapy 22(8): 985-997, August 2011.
White JD, Thesier DM, Swain JD, Katz MG, Tomasulo C, Henderson A, Yarnall C, Fargnoli A, Sumaroka M, Isidro A, Petrov M, Wang L, Holt D, Nolen-Walston R, Koch WJ, Rabinowitz J, Stedman HH, and Bridges CR: Myocardial Gene Delivery Using Molecular Cardiac Surgery with Recombinant Adeno-associated Virus Vectors In vivo. Gene Therapy 18: 546-552. June 2011.