Wenliang Song, MD, MS, MTR
Wenliang Song, MD, MS, MTR
Research Assistant Professor of Pharmacology
Department: Pharmacology
Contact information
Institute for Translational Medicine and Therapeutics
University of Pennsylvania
8040 Maloney Building
3600 Spruce St.
Philadelphia, PA 19104-6160
University of Pennsylvania
8040 Maloney Building
3600 Spruce St.
Philadelphia, PA 19104-6160
Office: (215) 746-2684
Fax: (215) 573-9004
Fax: (215) 573-9004
Email:
song5@mail.med.upenn.edu
song5@mail.med.upenn.edu
Publications
Links
Search PubMed for articles
Institute for Translational Medicine and Therapeutics - Wenliang Song MD
School of Medicine- Wenliang Song MD
Search PubMed for articles
Institute for Translational Medicine and Therapeutics - Wenliang Song MD
School of Medicine- Wenliang Song MD
Education:
MD, MS (Cardiovascular Medicine )
Shandong University School of Medicine, 2003.
MTR (Masters in Translational Research)
Perelman School of Medicine, University of Pennsylvania, 2012.
Permanent linkMD, MS (Cardiovascular Medicine )
Shandong University School of Medicine, 2003.
MTR (Masters in Translational Research)
Perelman School of Medicine, University of Pennsylvania, 2012.
Description of Research Expertise
Translational and clinical research in eicosanoids particularly relating to omega-3 polyunsaturated acids and prostaglandin D (PGD) in cardiovascular diseasesSelected Publications
Paschos GK, Ibrahim S, Song WL, Kunieda T, Grant G, Reyes TM, Bradfield CA, Vaughan CH, Eiden M, Masoodi M, Griffin JL, Wang F, Lawson JA, Fitzgerald GA: Obesity in mice with adipocyte-specific deletion of clock component Arntl. Nature Medicine doi: 10.1038/nm.2979. ([Epub ahead of print]), Nov 11 2012.Song WL, Stubbe J, Ricciotti E, Alamuddin N, Ibrahim S, Crichton I, Prempeh M, Lawson JA, Wilensky RL, Rasmussen LM, Puré E, Fitzgerald GA. : Niacin and biosynthesis of PGD2 by platelet COX-1 in mice and humans. J Clin Invest. pii:59262.doi:10.1172/JCI59262, 2012 Mar 12.
Tippin BL, Levine AJ, Materi AM, Song WL, Keku TO, Goodman JE, Sansbury LB, Das S, Dai A, Kwong AM, Lin AM, Lin JM, Park JM, Patterson RE, Chlebowski RT, Garavito RM, Inoue T, Cho W, Lawson JA, Kapoor S, Kolonel LN, Le Marchand L, Haile RW, Sandler RS, Lin HJ.: Hematopoietic prostaglandin D synthase (HPGDS): a high stability, Val187Ile isoenzyme common among African Americans and its relationship to risk for colorectal cancer. Prostaglandins Other Lipid Mediat. 97(1-2):22-8, 2012 Jan.
Winnik S, Lohmann C, Richter EK, Schäfer N, Song WL, Leiber F, Mocharla P, Hofmann J, Klingenberg R, Borén J, Becher B, FitzGerald GA, Lüscher TF, Matter CM, Beer JH: Dietary alpha-linolenic acid (ALA) diminishes experimental atherogenesis and restricts T cell-driven inflammation. Eur Heart J Page: Oct;32(20):2573-84. 2011.
Daham K, Song WL, Lawson JA, Kupczyk M, Gulich A, Dahlen SE, FitzGerald GA, Dahlen B: Effects of celecoxib on major prostaglandins in asthma. Clin Exp Allergy 41(1): 36-45, 2011.
Yu Y, Stubbe J, Ibrahim S, Song WL, Smyth EM, Funk CD, FitzGerald GA: Cyclooxygenase-2-dependent prostacyclin formation and blood pressure homeostasis: Targeted exchange of cyclooxygenase isoforms in mice. Circulation Res 106(2): 337-345, 2009.
Chang CT, Patel P, Gore V, Song WL, Lawson JA, Powell WS, FitzGerald GA, Rokach J: A new approach to the synthesis of polyunsaturated deuterated isoprostanes: Total synthesis of d4-5-epi-8,12-iso-iPF3alpha-VI and d4-8,12-iso-iPF3alpha-VI. Bioorg Med Chem Lett 19(23): 6755-6758, 2009.
An G, Miwa T, Song WL, Lawson JA, Rader DJ, Zhang Y, Song WC: CD59 but not DAF deficiency accelerates atherosclerosis in female ApoE knockout mice. Mol Immunol 46(8-9): 1702-1709, 2009.
Wang M, Song WL, Cheng Y, FitzGerald GA: Microsomal prostaglandin E synthase-1 inhibition in cardiovascular inflammatory disease. J Intern Med 263(5): 500-505, 2008.
Wang M, Lee E, Song W, Ricciotti E, Rader DJ, Lawson JA, Pure E, FitzGerald GA: Microsomal prostaglandin E synthase-1 deletion suppresses oxidative stress and angiotensin II-induced abdominal aortic aneurysm formation. Circulation 117(10): 1302-1309, 2008.
Song WL, Wang M, Ricciotti E, Fries S, Yu Y, Grosser T, Reilly M, Lawson JA, FitzGerald GA: Tetranor PGDM: An abundant urinary metabolite reflects biosynthesis of PGD2 in mice and humans. J Biol Chem 283(2): 1179-1188, 2008.
Song WL, Paschos G, Fries S, Reilly MP, Yu Y, Rokach J, Chang CT, Patel P, Lawson JA, FitzGerald GA: Novel eicosapentaenoic acid-derived F3-isoprostanes as biomarkers of lipid peroxidation. J Biol Chem 284(35): 23636-23643, 2009.
Chang CT, Patel P, Kang N, Lawson JA, Song WL, Powell WS, FitzGerald GA, Rokach J: Eicosapentaenoic-acid-derived isoprostanes: synthesis and discovery of two major isoprostanes. Bioorg Med Chem Lett 18(20):5523-7, Oct 15 2008
Song WL, Lawson JA, Reilly D, Rokach J, Chang CT, Giasson B, FitzGerald GA: Neurofurans: Novel indices of oxidant stress derived from docosahexaenoic acid. J Biol Chem 283(2): 1179-1188, 2008.
Song WL, Lawson JA, Wang M, Zou H, FitzGerald GA: Noninvasive assessment of the role of cyclooxygenases in cardiovascular health: A detailed HPLC/MS/MS method. Methods Enzymol 433: 51-72, 2007.
Rudic RD, Brinster D, Cheng Y, Fries S, Song WL, Austin S, Coffman TM, FitzGerald GA: COX-2 derived prostacyclin modulates vascular remodeling. Circulation Res 96(12): 1240-1247, June, 2005.