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Max Kelz, MD PhD

Assistant Professor of Anesthesiology and Critical Care

Department: Anesthesiology and Critical Care

Graduate Group Affiliations

Contact information

3620 Hamilton Walk,
John Morgan Building - Room 334
Philadelphia, PA 19104

Office: 215 662-3713
Fax: 215 349-5078

Email:
kelzma@uphs.upenn.edu

Links
Max Kelz homepage, Department of Anesthesiology and Critical Care University of Pennsylvania School of Medicine
Kelz homepage, Mahoney Institute of Neurological Sciences

Education:
BS (Molecular Biophysics and Biochemistry)
Yale University, 1993.
MS (Molecular Biophysics and Biochemistry)
Yale University, 1993.
PhD (Neuroscience)
Yale University, 1999.
MD (Medicine)
Yale University, 2000.

Permanent link

School of Medicine > Faculty > Search

Description of Research Expertise

Molecular Mechanisms of Anesthetic Action
Neurobiology of Sleep Wake Regulation
Mouse Genetics
Molecular Biology
Anesthetic pharmacology

Description of Clinical Expertise

Anesthesiology

Selected Publications

Hu FY, Hanna GM, Wei H, Mardini F, Thomas SA, Wyner AJ, Kelz MB: Hypnotic Hypersensitivity to Volatile Anesthetics and Dexmedetomidine in Dopamine ß-Hydroxylase Knockout Mice. Anesthesiology 117(5): 1006-17, November 2012 Notes: Published with an accompanying an Editorial, Sanders RD and Maze M, Anesthesiology 2012; 117:945-7.

Moore JT, Chen J, Han B, Meng Q-C, Veasey SC, Beck SG, Kelz MB: Direct Activation of Sleep-Promoting VLPO Neurons by Volatile Anesthetics Contributes to Anesthetic Hypnosis. Current Biology 22: 2008-16, November 2012 Notes: Published with an editorial by Solt Current Biology 2012 22:R918-9. Publication was the subject of a Nature News and Views http://www.nature.com/nature/journal/v491/n7422/full/491046a.html?WT.ec_id=NATURE-20121101.

Rosie Q Li, Andrew R. McKinstry, Jason T Moore, Breanna M Caltagarone, Maryellen F Eckenhoff, Roderic G Eckenhoff, Max B Kelz: Is hydrogen sulfide induced suspended animation general anesthesia? JPET 341(3): 735-42, June 2012.

Newman J, Blake K, Fennema J, Harris D, Shanks A, Avidan MS, Kelz MB, Mashour GA. : Incidence, risk factors and outcomes of postoperative coma: an observational study of 858,606 patients. European Journal of Anesthesiology Accepted for Publication, 2012.

Pick Jeremy, Chen Yihan, Moore Jason T, Sun Yi, Wyner Abraham J, Friedman Eliot B, Kelz Max B: Rapid Eye Movement Sleep Debt Accrues in Mice Exposed to Volatile Anesthetics. Anesthesiology 115(4): 702-712, Oct 2011 Notes: Accompanied by an editorial: Anesthesiology 2011 115(4)683-4. PMID 21829133.

Friedman EB, Sun Y, Moore JT, Tung H, Meng QC, Perera P, Joiner WJ, Thomas SA, Eckenhoff RG, Sehgal A, Kelz MB: A Conserved Behavioral State Barrier Impedes Transitions between Anesthetic-Induced Unconsciousness and Wakefulness: Evidence for Neural Inertia PLOS ONE 5(7): e11903, July 2010 Notes: Editorial in Science Translational Medicine; http://stm.sciencemag.org.proxy.lib.umich.edu/content/3/98/98ec140.full?sid=860ebb91-6c41-4158-9fe8-8cb38e8d91f6.

Bianchi SL, Caltagarone MS, Oddo S, LeFerla FM, Eckenhoff RG, Kelz MB: Inhaled Anesthetic Potency in Aged Alzheimer's Mice. Anesthesia and Analgesia 110: 427-430, Feb 2010 Notes: Accompanied by an editorial: Anesthesia and Analgesia 2010 110:2 291-2. PMID 20081125.

Gompf H, Chen J, Sun Y, Yanagisawa M, Aston-Jones G, Kelz MB : Halothane-induced Hypnosis Is Not Accompanied by Inactivation of Orexinergic Output in Rodents Anesthesiology 111(5): 1001-1009, November 2009.

Kelz MB, Sun Y, Chen J, Meng QC, Moore JT, Veasey SC, Dixon S, Thornton Ml, Funato H, Yanagisawa M: An Essential Role for Orexins in Emergence from General Anesthesia. Proceedings of the National Academy of Sciences 105(4): 1309-1314, January 2008 Notes: (commentary in PNAS 2008 v.105(7) 2257-8, 18272494).

Zhu Y, Fenik P, Zhan G, Mazza E, Kelz M, Aston-Jones G, Veasey SC: Selective loss of catecholaminergic wake active neurons in a murine sleep apnea model. Journal of Neuroscience 27(37): 10060-71, Sep 2007.