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Perelman School of Medicine at the University of Pennsylvania Advanced Search

Max B. Kelz, MD PhD

Max B. Kelz, MD PhD

faculty photo
Associate Professor of Anesthesiology and Critical Care
Department: Anesthesiology and Critical Care
Graduate Group Affiliations

Contact information
3620 Hamilton Walk,
John Morgan Building - Room 334
Philadelphia, PA 19104
Office: 215 662-3713
Fax: 215 349-5078
Education:
BS (Molecular Biophysics and Biochemistry)
Yale University, 1993.
MS (Molecular Biophysics and Biochemistry)
Yale University, 1993.
PhD (Neuroscience)
Yale University, 1999.
MD (Medicine)
Yale University, 2000.
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Description of Research Expertise

Molecular Mechanisms of Anesthetic Action
Neurobiology of Sleep Wake Regulation
Mouse Genetics
Molecular Biology
Anesthetic pharmacology

Description of Clinical Expertise

Anesthesiology

Selected Publications

Han B, McCarren HS, O'Neill D, Kelz MB: Distinctive Recruitment of Endogenous Sleep-promoting Neurons by Volatile Anesthetics and a Nonimmobilizer. Anesthesiology in press, 2014.

Deutschman CS, Raj NR, McGuire EO, Kelz MB: Orexinergic Activity Modulates Altered Vital Signs and Pituitary Hormone Secretion in Experimental Sepsis. Critical Care Medicine 41(11): e368-75, Nov 2013.

McCarren HS, Moore JT, Kelz MB: Assessing changes in volatile general anesthetic sensitivity of mice after local or systemic pharmacological intervention JoVE 80: e51079, October 2013.

Joiner WJ, Friedman EB, Hung H-T, Koh K, Sowcik M, Sehgal A, Kelz MB: Genetic and anatomical basis of the barrier separating wakefulness and anesthetic-induced unresponsiveness. PLoS Genetics 9(9): e1003605, September 2013 Notes: Published with an editorial by Sanders RD and Maze M: Take Off, Landing, and Fly Anesthesia PLoS Genetics 9(9): e1003788, 2013.

Newman J, Blake K, Fennema J, Harris D, Shanks A, Avidan MS, Kelz MB, Mashour GA. : Incidence, risk factors and outcomes of postoperative coma: an observational study of 858,606 patients. European Journal of Anesthesiology 30(8): 476-82, Aug 2013.

Kretschmannova K, Hines RM, Revilla-Sanchez R, Terunuma M, Tretter V, Jurd R, Kelz MB, Moss SJ, Davies PA: Enhanced tonic inhibition influences the hypnotic and amnestic actions of the intravenous anesthetics etomidate and propofol. Journal of Neuroscience 33(17): 7264-73, April 2013.

Weiser BP, Kelz MB, Eckenhoff RG: In vivo activation of azi-propofol prolongs anesthesia and reveals synaptic targets. J Biol Chem 288(2): 1279-85, Jan 2013.

Hu FY, Hanna GM, Wei H, Mardini F, Thomas SA, Wyner AJ, Kelz MB: Hypnotic hypersensitivity to volatile anesthetics and dexmedetomidine in dopamine ß-hydroxylase knockout mice. Anesthesiology 117(5): 1006-17, November 2012 Notes: Published with an accompanying an Editorial, Sanders RD and Maze M, Anesthesiology 2012; 117:945-7.

Moore JT, Chen J, Han B, Meng Q-C, Veasey SC, Beck SG, Kelz MB: Direct activation of sleep-promoting VLPO neurons by volatile anesthetics contributes to anesthetic hypnosis. Current Biology 22: 2008-16, November 2012 Notes: Published with an editorial by Solt Current Biology 2012 22:R918-9. Publication was the subject of a Nature News and Views http://www.nature.com/nature/journal/v491/n7422/full/491046a.html?WT.ec_id=NATURE-20121101.

Li RQ, McKinstry AR, Moore JT, Caltagarone BM, Eckenhoff MF, Eckenhoff RG, Kelz MB: Is hydrogen sulfide induced suspended animation general anesthesia? JPET 341(3): 735-42, June 2012.

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Last updated: 09/24/2014
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