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Perelman School of Medicine at the University of Pennsylvania Advanced Search

Gregory D. Van Duyne,

Gregory D. Van Duyne

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Jacob Gershon-Cohen Professor of Medical Science
Department: Biochemistry and Biophysics
Graduate Group Affiliations

Contact information
809B Stellar-Chance
Philadelphia, PA 19104-6059
Office: (215) 898-3058
Fax: (215) 573-4764
Education:
B.S. (Chemistry)
Cornell University, 1983.
Ph.D. (Biophysical Chemistry)
Cornell University, 1988.
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Description of Research Expertise

We are interested in understanding on a structural and biochemical level how DNA and RNA molecules are maintained and processed by living cells. In addition to the mechanisms and regulation of genome replication and transcription, this includes processes such as DNA repair, site-specific and homologous recombination, transposition, condensation of chromosomes, chromosome pairing and segregation, and RNA trafficking and splicing. Our approach is to establish three-dimensional models of macromolecular assemblies relating to a particular biological question using X-ray diffraction methods and to then develop mechanistic and functional models that can be tested experimentally.

Selected Publications

Ghosh, K. & Van Duyne, G.D. : Cre-loxP Biochemistry. Methods 28: 374-383, 2002.

Van Duyne, G.D. : A structural view of tyrosine recombinase site-specific recombination. Mobile DNA II Craig, N., Craigie, R., Gellert, M., & Lambowitz, A.M. (eds.). ASM Press, Page: Ch. 6, 2002.

Van Duyne, G.D. : A structural view of Cre-loxP site-specific recombination. Ann Rev. Biophys. Biomol. Struct. 30: 87-104, 2001.

Friesen WJ, Paushkin S, Wyce A, Massenet S, Pesiridis GS, Van Duyne G, Rappsilber J, Mann M, Dreyfuss G. : The methylosome, a 20S complex containing JBP1 and pICln, produces dimethylarginine-modified Sm proteins. Mol. Cell. Biol. 21: 8289-300, 2001.

Dimova, D., Weigel, P., Takahashi, M., Marc, F., Van Duyne, G. D. & Sakanyan, V. : Thermostability, oligomerization and DNA-binding properties of the regulatory protein ArgR from the hyperthermophilic bacterium Thermotoga neapolitana. Mol Gen Genet 263(1): 119-30, 2000.

Guo, F., Gopaul, D.N., Van Duyne, G. D.: Geometry of the DNA substrates in Cre-loxP site-specific recombination. J. Biomol. Struct. & Dynamics 11: 141, 2000.

Gopaul, D.N. & Van Duyne, G.D. : Structure and mechanism in site-specific recombination. Curr. Op. in Struc. Biol. 9: 14-20, 1999.

Karaivanova, I. M., Weigel, P., Takahashi, M., Fort, C., Versavaud, A., Van Duyne, G., Charlier, D., Hallet, J. N., Glansdorff, N. & Sakanyan, V. : Mutational analysis of the thermostable arginine repressor from Bacillus stearothermophilus: dissecting residues involved in DNA binding properties. J Mol Biol 291(4): 843-55, 1999.

Guo, F., Gopaul, D.N., Van Duyne, G.D. : Asymmetric DNA-bending in the Cre-loxP site-specific recombination synapse. Proc. Natl. Acad. Sci. USA 96: 7143-7148, 1999.

Ni, J., Sakanyan, V., Charlier, D., Glansdorff, N., & Van Duyne, G.D. : Structure of the arginine repressor. Bacillus Stearothermophilus Nature Struct. Biol. 6: 427-432, 1999.

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Last updated: 10/01/2004
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