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Mortimer Poncz, MD

Mortimer Poncz, MD

faculty photo
Professor of Pediatrics
Department: Pediatrics
Graduate Group Affiliations

Contact information
3615 Civic Center Blvd.
Division of Hematology
The Children's Hospital of Philadelphia
Abramson Research Bdg. Rm. 317
Philadelphia, PA 19104-4318
Office: (215) 590-3574
Fax: (267) 426-5476
Columbia University, 1972.
University of Pennsylvania, 1976.
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Description of Research Expertise

Research Interests
Role of platelets in thrombus development

Key words: platelet; megakaryocyte; hematopoiesis; thrombosis.

Description of Research
My research efforts focus on the megakaryocyte-platelet-thrombus axis. The process by which hematopoietic stem cells differentiate into megakaryocytes, which then release platelets and the function of platelets in thrombosis and inflammation are the central foci of my laboratory. Many of the studies focus on the biology and pathobiology of the platelet-specific proteins, chemokines Platelet Factor 4 (PF4)/Platelet Basic Protein (PBP) and the integrin alphaIIb/beta3 receptor.

Rotation Projects for 2006-2007
1. Murine models of thrombosis.
2. Regulation of megakaryocyte gene expression.
3. Gene therapy lentiviral studies for bleeding disorders. Chemokine sin thrombosis and angiogenesis.

Lab personnel:
1 grad student
1 MD post-doc
3 PhD post-docs
5 lab techs
1 Assist Prof Res

Selected Publications

Lyde R, Sabatino D, Sullivan S K, Poncz M: Platelet-delivered therapeutics. Journal of thrombosis and haemostasis : JTH 13 Suppl 1: S143-50, Jun 2015.

Noh Ji-Yoon, Gandre-Babbe Shilpa, Wang Yuhuan, Hayes Vincent, Yao Yu, Gadue Paul, Sullivan Spencer K, Chou Stella T, Machlus Kellie R, Italiano Joseph E, Kyba Michael, Finkelstein David, Ulirsch Jacob C, Sankaran Vijay G, French Deborah L, Poncz Mortimer, Weiss Mitchell J: Inducible Gata1 suppression expands megakaryocyte-erythroid progenitors from embryonic stem cells. The Journal of clinical investigation 125(6): 2369-74, Jun 2015.

Joglekar Manali, Khandelwal Sanjay, Cines Douglas B, Poncz Mortimer, Rauova Lubica, Arepally Gowthami M: Heparin enhances uptake of platelet factor 4/heparin complexes by monocytes and macrophages. Journal of thrombosis and haemostasis : JTH May 2015.

Wang Yuhuan, Hayes Vincent, Jarocha Danuta, Sim Xiuli, Harper Dawn C, Fuentes Rudy, Sullivan Spencer K, Gadue Paul, Chou Stella T, Torok-Storb Beverly J, Marks Michael S, French Deborah L, Poncz Mortimer: Comparative analysis of human ex vivo-generated platelets vs. megakaryocyte-generated platelets in mice: A cautionary tale. Blood 125(23): 3627-36, Apr 2015.

Pickens Brandy, Mao Yingying, Li Dengju, Siegel Don L, Poncz Mortimer, Cines Douglas B, Zheng X Long: Platelet-delivered ADAMTS13 inhibits arterial thrombosis and prevents murine models of thrombotic thrombocytopenic purpura. Blood 125(21): 3326-34, Mar 2015.

Meng Ronghua, Wu Jie, Harper Dawn C, Wang Yuhuan, Kowalska M Anna, Abrams Charles S, Brass Lawrence F, Poncz Mortimer, Stalker Timothy J, Marks Michael S: Defective release of α granule and lysosome contents from platelets in mouse Hermansky-Pudlak syndrome models. Blood 125(10): 1623-32, Mar 2015.

Bruns Ingmar, Lucas Daniel, Pinho Sandra, Ahmed Jalal, Lambert Michele P, Kunisaki Yuya, Scheiermann Christoph, Schiff Lauren, Poncz Mortimer, Bergman Aviv, Frenette Paul S: Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion. Nature medicine 20(11): 1315-20, Nov 2014.

Zhou J, Wu Y, Wang L, Rauova L, Hayes V M, Poncz M, Essex D W: The disulfide isomerase ERp57 is required for fibrin deposition in vivo. Journal of thrombosis and haemostasis : JTH 12(11): 1890-7, Nov 2014.

Greene T K, Lyde R B, Bailey S C, Lambert M P, Zhai L, Sabatino D E, Camire R M, Arruda V R, Poncz M: Apoptotic effects of platelet factor VIII on megakaryopoiesis: implications for a modified human FVIII for platelet-based gene therapy. Journal of thrombosis and haemostasis : JTH 12(12): 2102-12, Oct 2014.

Skewis Lynell R, Lebedeva Tatiana, Papkov Vyacheslav, Thayer Edward C, Massefski Walter, Cuker Adam, Nagaswami Chandrasekaran, Litvinov Rustem I, Kowalska M Anna, Rauova Lubica, Poncz Mortimer, Weisel John W, Lowery Thomas J, Cines Douglas B: T2 Magnetic Resonance: A Diagnostic Platform for Studying Integrated Hemostasis in Whole Blood-Proof of Concept. Clinical chemistry 60(9): 1174-82, Jun 2014.

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Last updated: 07/14/2015
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