Mortimer Poncz, MD
Mortimer Poncz, MD
Professor of Pediatrics
Department: Pediatrics
Graduate Group Affiliations
Contact information
317 Abramson Research Center
The Children’s Hospital of Philadelphia
3615 Civic Center Blvd
Philadelphia, PA 19104-4318
The Children’s Hospital of Philadelphia
3615 Civic Center Blvd
Philadelphia, PA 19104-4318
Office: (215) 590-3574
Fax: (215) 590-4834
Fax: (215) 590-4834
Email:
poncz@email.chop.edu
poncz@email.chop.edu
Publications
Links
Search PubMed for articles
Joseph Stokes Jr. Research Institute Profile
Pharmacological Sciences Graduate Group
Cell and Molecular Biology Graduate Group
Search PubMed for articles
Joseph Stokes Jr. Research Institute Profile
Pharmacological Sciences Graduate Group
Cell and Molecular Biology Graduate Group
Education:
B.S.
Columbia University, 1972.
M.D.
University of Pennsylvania, 1976.
Permanent linkB.S.
Columbia University, 1972.
M.D.
University of Pennsylvania, 1976.
Description of Research Expertise
Research InterestsRole of platelets in thrombus development
Key words: platelet; megakaryocyte; hematopoiesis; thrombosis.
Description of Research
My research efforts focus on the megakaryocyte-platelet-thrombus axis. The process by which hematopoietic stem cells differentiate into megakaryocytes, which then release platelets and the function of platelets in thrombosis and inflammation are the central foci of my laboratory. Many of the studies focus on the biology and pathobiology of the platelet-specific proteins, chemokines Platelet Factor 4 (PF4)/Platelet Basic Protein (PBP) and the integrin alphaIIb/beta3 receptor.
Rotation Projects for 2006-2007
1. Murine models of thrombosis.
2. Regulation of megakaryocyte gene expression.
3. Gene therapy lentiviral studies for bleeding disorders. Chemokine sin thrombosis and angiogenesis.
Lab personnel:
1 grad student
1 MD post-doc
3 PhD post-docs
5 lab techs
1 Assist Prof Res
Selected Publications
Nassar T, Sachais BS, Akkawi S, Kowalska MA, Bdeir K, Leitersdorf E, Hiss E, Ziporen L, Aviram M, Cines D, Poncz M, Higazi AA-R. : Platelet Factor 4 enhances the binding of oxidized-low density lipoprotein to vascular wall cells. J Biol Chem 278: 6187-93, 2003.Rozmyslowicz T, Majka M, Kijowski J, Murphy SL, Conover DO, Poncz M, Ratajczak J, Gaulton GN, Ratajczak MZ. : Platelet- and megakaryocyte-derived microparticles transfer CXCR4 receptor to CXCR4-null cells and make them susceptible to infection by X4-HIV. AIDS 17: 33-42, 2003.
Kufrin D, Eslin DE, Bdeir K, Murciano J-C, Kuo A, Kowalska MA, Degen JL, Sachais BS, Cines DB, Poncz M. : Anti-thrombotic thrombocytes: Ectopic expression of urokinase-type plasminogen activator in platelets. Blood 102: 926-33, 2003.
Sachais BS, Kuo A, Morgan J, Kariko K, Poncz M, Williams KJ, Feldman M, Shah N, Jarett L, Cines DB, Higazi AA-R. : Platelet factor 4 binds to the low density lipoprotein receptor and inhibits receptor-dependent binding, endocytosis and degradation of low density lipoprotein. Blood 99: 3613-22, 2002.
Li ZQ, Liu W, Park KS, Sachais BS, Arepally GM, Cines DB, Poncz M: Defining a second epitope for Heparin-Induced Thrombocytopenia/Thrombosis (HIT/T) antibodies using KKO, a Murine HIT-like monoclonal antibody. Blood 99: 1230-1236, 2002.
Sachais BS, Kuo A, Nassar T, Morgan J, Kariko K, Williams KJ, Feldman M, Aviram M, Shah N, Jarett L, Poncz M, Cines DB, Higazi AA-R. : Platelet factor 4 binds to low-density lipoprotein receptors and disrupts the endocytic itinerary, resulting in retention of low-density lipoprotein. Blood 99: 3613-22, 2002.
Fang J, Hsu BY, MacMullen CM, Poncz M, Smith TJ, Stanley CA. : Expression, purification and characterization of human glutamate dehydrogenase (GDH) allosteric regulatory mutations. Biochemical J 363: 81-87, 2002.
Thornton MA, Zhang C, Cheng J-F, Kowalska MA, Poncz M: Distal regulatory regions 5¡¦ and 3¡¦ to the human ƒÑIIb gene confer copy number-dependent and enhanced expression, respectively, in transgenic animals. Blood 100: 3588-96, 2002.
Wang X, Crispino JD, Orkin SH, Poncz M , Blobel G: Cooperativity between GATA-1, FOG-1 and FLI1 during activation of a megakaryocyte-specific gene ĄIIb in vivo. EMBO J 21: 5225-34, 2002.
Basani RB, D¡¦Andrea G, Mitra N, Vilaire G, Richberg M, Kowalska MA, Bennett JS, Poncz M. : Arg-Gly-Asp (RGD)-containing Peptides inhibit fibrinogen binding to platelet ƒÑIIb/ƒÒ3 by inducing an allosteric change in the amino-terminal portion of ƒÑIIb. J Biol Chem 276: 13975-81, 2001.