Marcelo Gabriel Kazanietz, Ph.D.
Marcelo Gabriel Kazanietz, Ph.D.
Professor of Pharmacology
Department: Pharmacology
Graduate Group Affiliations
Contact information
Institute for Translational Medicine & Therapeutics
University of Pennsylvania School of Medicine
1256 Biomedical Building II/III
421 Curie Boulevard
Philadelphia, PA 19104-6160
University of Pennsylvania School of Medicine
1256 Biomedical Building II/III
421 Curie Boulevard
Philadelphia, PA 19104-6160
Office: (215) 898-0253
Fax: (215) 746-8941
Fax: (215) 746-8941
Email:
MARCELOG@MAIL.MED.UPENN.EDU
MARCELOG@MAIL.MED.UPENN.EDU
Publications
Links
Search PubMed for articles
Biochemistry and Molecular Biophysics graduate group faculty webpage.
Pharmacological Sciences graduate group faculty webpage.
Department of Pharmacology faculty member webpage
Primary Work Website
Search PubMed for articles
Biochemistry and Molecular Biophysics graduate group faculty webpage.
Pharmacological Sciences graduate group faculty webpage.
Department of Pharmacology faculty member webpage
Primary Work Website
Education:
MSc. (Pharmacy)
University of Buenos Aires, Argentina, 1983.
MSc. (Biochemistry)
University of Buenos Aires, Argentina, 1987.
Ph.D. (Pharmacology)
University of Buenos Aires, Argentina, 1989.
Permanent linkMSc. (Pharmacy)
University of Buenos Aires, Argentina, 1983.
MSc. (Biochemistry)
University of Buenos Aires, Argentina, 1987.
Ph.D. (Pharmacology)
University of Buenos Aires, Argentina, 1989.
Description of Research Expertise
Dr. Kazanietz studies the receptors for the phorbol ester tumor promoters and the second messenger diacylglycerol (DAG), an important intracellular mediator of proliferation and malignant transformation. His lab is exploring the role of PKC isozymes (the main phorbol ester/DAG receptors) in prostate carcinogenesis,and the signal transduction pathways regulated by each PKC isozyme, including the MAPK cascades and Akt/PKB. The second area of research involves the "chimaerins", novel phorbol ester/DAG receptors with Rac-GAP activity. Rac is a small GTP-binding protein that regulates actin cytoskeleton organization, cell cycle progression, gene expression, adhesion and migration. He is currently focusing on the cellular functions of chimaerin isoforms and we are isolating interacting proteins that control their subcellular localization and activity.Selected Publications
Wertheimer Eva, Kazanietz Marcelo G: Rac1 Takes Center Stage in Pancreatic Cancer and Ulcerative Colitis: Quantity Matters. Gastroenterology Jun 2011.Wang HongBin, Xiao Liqing, Kazanietz Marcelo G: p23/Tmp21 associates with protein kinase Cdelta (PKCdelta) and modulates its apoptotic function. The Journal of biological chemistry 286(18): 15821-31, May 2011.
Caino M Cecilia, von Burstin Vivian A, Lopez-Haber Cynthia, Kazanietz Marcelo G: Differential regulation of gene expression by protein kinase C isozymes as determined by genome-wide expression analysis. The Journal of biological chemistry 286(13): 11254-64, Apr 2011.
Kazanietz Marcelo G, Lemmon Mark A: Protein kinase C regulation: C1 meets C-tail. Structure 19(2): 144-6, Feb 2011.
Benavides Fernando, Blando Jorge, Perez Carlos J, Garg Rachana, Conti Claudio J, DiGiovanni John, Kazanietz Marcelo G: Transgenic overexpression of PKCε in the mouse prostate induces preneoplastic lesions. Cell cycle 10(2): 268-77, Jan 2011.
Sosa Maria Soledad, Lopez-Haber Cynthia, Yang Chengfeng, Wang Hongbin, Lemmon Mark A, Busillo John M, Luo Jiansong, Benovic Jeffrey L, Klein-Szanto Andres, Yagi Hiroshi, Gutkind J Silvio, Parsons Ramon E, Kazanietz Marcelo G: Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer. Molecular cell 40(6): 877-92, Dec 2010.
von Burstin Vivian A, Xiao Liqing, Kazanietz Marcelo G: Bryostatin 1 inhibits phorbol ester-induced apoptosis in prostate cancer cells by differentially modulating protein kinase C (PKC) delta translocation and preventing PKCdelta-mediated release of tumor necrosis factor-alpha. Molecular pharmacology 78(3): 325-32, Sep 2010.
Meshki John, Caino M Cecilia, von Burstin Vivian A, Griner Erin, Kazanietz Marcelo G: Regulation of prostate cancer cell survival by protein kinase Cepsilon involves bad phosphorylation and modulation of the TNFalpha/JNK pathway. The Journal of biological chemistry 285(34): 26033-40, Aug 2010.
Griner Erin M, Caino M Cecilia, Soledad Sosa Maria, Colón-González Francheska, Chalmers Michael J, Mischak Harald, Kazanietz Marcelo G: A novel cross-talk in diacylglycerol signaling: the Rac-GAP beta2-chimaerin is negatively regulated by protein kinase Cdelta-mediated phosphorylation. The Journal of biological chemistry 285(22): 16931-41, May 2010.
Wang Hongbin, Kazanietz Marcelo G: p23/Tmp21 differentially targets the Rac-GAP beta2-chimaerin and protein kinase C via their C1 domains. Molecular biology of the cell 21(8): 1398-408, Apr 2010.