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Vijay Srinivasan, MD

Vijay Srinivasan, MD

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Assistant Professor of Anesthesiology and Critical Care at the Hospital of the University of Pennsylvania and the Children's Hospital of Philadelphia
Department: Anesthesiology and Critical Care

Contact information
Department of Anesthesiology and Critical Care Medicine
The Children's Hospital of Philadelphia
34th Street and Civic Center Boulevard
Philadelphia, PA 19104-4399
Office: 215-590-5505
Fax: 215-590-4327
All-India Institute of Medical Sciences, New Delhi, India, 1995.
MD (Pediatrics)
All-India Institute of Medical Sciences, New Delhi, India, 1998.
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Description of Clinical Expertise

Dr. Srinivasan is a full-time attending physician at the Pediatric Intensive Care Unit (PICU) and Progressive Care Unit (PCU) at CHOP. The PICU at CHOP is a 55-bed tertiary care medical/surgical unit with approximately 3700 admissions every year and serves the Delaware Valley region of south-eastern Pennsylvania and adjoining southern New Jersey with national international referrals. The PICU offers advanced modes of ventilation, nitric oxide therapy, surfactant therapy, continuous and intermittent renal replacement therapies, extracorporeal life support therapy and advanced modes of blood exchanges. The PICU offers an accredited 3 year fellowship program supervised by board-certified PICU faculty members. The PICU manages all patients with close input from multiple consulting services and sub-specialties.

Description of Research Expertise

Dr. Srinivasan is engaged in research in endocrinopathies and nutrition in critically ill children. He is a Co-Investigator (10% effort) and local site PI on the NHLBI funded Heart and Lung Failure - Pediatric Insulin Titration (HALF-PINT) study (NHLBI/HL107681 PI: Agus/Nadkarni) involving multiple PALISI sites. He is also site PI for the ancillary study Coagulation and Fibrinolysis - Pediatric Insulin Titration (CAF-PINT) with HALF-PINT. Locally, he studies the association of stress hyperglycemia/ blood glucose variability with key outcomes in the PICU population. Dr. Srinivasan also seeks to improve anthropometry measurements and delivery of enteral nutrition in the PICU population. He is PI of a CHOP CTRC supported study on measurement and validation of resting energy expenditure in children chronically mechanically ventilated via tracheostomy. He is PI of an industry sponsored study with NIH SBIR/STTR support to evaluate the efficacy of using TubeClear to restore patency in occluded enteral access devices in children in the ICU. He is collaborating with Dr. Katri Typpo (University of Arizona) to study the role of biomarkers of effects of enteral/parenteral nutrition on intestinal epithelium in the SUPPER study.

Selected Publications

Agus MSD, Wypij D, Hirshberg EL, Srinivasan V, Faustino EV, Luckett PM, Alexander JL, Asaro, LA, Curley MAQ, Steil GM, Nadkarni VM, for the HALF-PINT Study Investigators and PALISI Network. : Tight glycemic control in critically ill children. New England Journal of Medicine 376: 729-741, February 2017.

Srinivasan V, Seiple S, Nagle M, Falk S, Kubis S, Lee HM, Sisko M, Mascarenhas M, Irving S: Improving the Performance of Anthropometry Measurements in the Pediatric Intensive Care Unit Pediatric Quality and Safety in press 2017.

Agus MS, Hirshberg E, Srinivasan V, Faustino EV, Luckett PM, Curley MAQ, Alexander J, Asaro LA, Coughlin-Wells K, Duva D, French J, Hasbani N, Sisko MT, Soto-Rivera CL, Steil G, Wypij D, Nadkarni VM, and HALF-PINT Study Investigators and the Pediatric Acute Lung Injury and Sepsis Investigators Network.: Design and rationale of Heart and Lung Failure – Pediatric INsulin Titration Trial (HALF-PINT): A randomized clinical trial of tight glycemic control in hyperglycemic critically ill children. Contemporary Clinical Trials 53: 178-187, December 2016 Notes: doi: 10.1016/j.cct.2016.12.023 [Epub ahead of print]

Yehya N, Vogiatzi M, Thomas NJ, Srinivasan V: Cortisol correlates with severity of illness and poorly reflects adrenal function in pediatric acute respiratory distress syndrome. Journal of Pediatrics 177: 212-218.e1, October 2016 Notes: doi: 10.1016/j.jpeds.2016.05.020. Epub 2016 Jun 6.

Irving SY, Seiple S, Nagle M, Falk S, Mascarenhas M, Srinivasan V.: Perceived barriers to anthropometric measurements in critically ill children. American Journal of Critical Care 24(6): e99-e107, November 2015.

Marsillio LE, Ginsburg SL, Rosenbaum CH, Coffin SE, Naim MY, Priestley MA, Srinivasan V.: Hyperglycemia at the time of acquiring central line-associated blood stream infections is associated with mortality in critically ill children. Pediatric Critical Care Medicine 16(7): 621-628, September 2015.

Yehya N, Servaes S, Thomas NJ, Nadkarni VM, Srinivasan V: Corticosteroid exposure in pediatric acute respiratory distress syndrome. Intensive Care Medicine 41(9): 1658-1666, September 2015.

Srinivasan V, Agus MSD: Tight glucose control in critically ill children: a systematic review and meta-analysis. Pediatric Diabetes 15(2): 75-83, March 2014.

Roberts K, Srinivasan V, Niles DE, Eilvstjonn J, Tyler L, Boyle L, Bishnoi R, Ferry S, Nysaether J, Stavland M, Litman RS, Helfaer M, Nadkarni VM: Does change in thoracic impedance measured via defibrillator electrode pads accurately detect ventilation breaths in children? Resuscitation 81(11): 1544-1549, November 2010.

Rake AJ, Srinivasan V, Nadkarni V, Kaptan R, Newth CJ: Glucose variability and survival in critically ill children: allostasis or harm? Pediatric Critical Care Medicine 11(6): 707-712, November 2010.

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Last updated: 03/28/2017
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