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Vijay Srinivasan, MD

Vijay Srinivasan, MD

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Assistant Professor of Anesthesiology and Critical Care at the Hospital of the University of Pennsylvania and the Children's Hospital of Philadelphia
Department: Anesthesiology and Critical Care

Contact information
Department of Anesthesiology and Critical Care Medicine
The Children's Hospital of Philadelphia
34th Street and Civic Center Boulevard
Philadelphia, PA 19104-4399
Office: 215-590-5505
Fax: 215-590-4327
All-India Institute of Medical Sciences, New Delhi, India, 1995.
MD (Pediatrics)
All-India Institute of Medical Sciences, New Delhi, India, 1998.
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Description of Clinical Expertise

Dr. Srinivasan is a full-time attending physician at the Pediatric Intensive Care Unit (PICU) and Progressive Care Unit (PCU) at CHOP. The PICU at CHOP is a 55-bed tertiary care medical/surgical unit with approximately 3700 admissions every year and serves the Delaware Valley region of south-eastern Pennsylvania and adjoining southern New Jersey with national international referrals. The PICU offers advanced modes of ventilation, nitric oxide therapy, surfactant therapy, continuous and intermittent renal replacement therapies, extracorporeal life support therapy and advanced modes of blood exchanges. The PICU offers an accredited 3 year fellowship program supervised by board-certified PICU faculty members. The PICU manages all patients with close input from multiple consulting services and sub-specialties.

Description of Research Expertise

Dr. Srinivasan is engaged in research in endocrinopathies and nutrition in critically ill children. He is a Co-Investigator (10% effort) and local site PI on the NHLBI funded Heart and Lung Failure - Pediatric Insulin Titration (HALF-PINT) study (NHLBI/HL107681 PI: Agus/Nadkarni) involving multiple PALISI sites. He is also site PI for the ancillary study Coagulation and Fibrinolysis - Pediatric Insulin Titration (CAF-PINT) with HALF-PINT. Locally, he studies the association of stress hyperglycemia/ blood glucose variability with key outcomes in the PICU population. Dr. Srinivasan also seeks to improve anthropometry measurements and delivery of enteral nutrition in the PICU population. He is PI of a CHOP CTRC supported study on measurement and validation of resting energy expenditure in children chronically mechanically ventilated via tracheostomy. He is PI of an industry sponsored study with NIH SBIR/STTR support to evaluate the efficacy of using TubeClear to restore patency in occluded enteral access devices in children in the ICU. He is collaborating with Dr. Katri Typpo (University of Arizona) to study the role of biomarkers of effects of enteral/parenteral nutrition on intestinal epithelium in the SUPPER study.

Selected Publications

Irving SY, Seiple S, Nagle M, Falk S, Mascarenhas M, Srinivasan V.: Perceived barriers to anthropometric measurements in critically ill children. American Journal of Critical Care 24(6): e99-e107, November 2015.

Yehya N, Servaes S, Thomas NJ, Nadkarni VM, Srinivasan V: Corticosteroid exposure in pediatric acute respiratory distress syndrome. Intensive Care Medicine 41(9): 1658-1666, September 2015.

Marsillio LE, Ginsburg SL, Rosenbaum CH, Coffin SE, Naim MY, Priestley MA, Srinivasan V.: Hyperglycemia at the time of acquiring central line-associated blood stream infections is associated with mortality in critically ill children. Pediatric Critical Care Medicine 16(7): 621-628, September 2015.

Srinivasan V: Tight glucose control with insulin following pediatric cardiac surgery: still “muscling” on in search of answers! Pediatric Critical Care Medicine 16(6): 587-588, July 2015 Notes: Editorial.

Srinivasan V, Agus MSD: Tight glucose control in critically ill children: a systematic review and meta-analysis. Pediatric Diabetes 15(2): 75-83, March 2014.

Srinivasan V: Nutrition and glucose management Pediatric Neurocritical Care. Abend NS, Helfaer MA (eds.). Demos Medical Publishing, New York, NY, Page: 81-90, 2013 Notes: Chapter.

Srinivasan V: Stress hyperglycemia in pediatric critical illness: The intensive care unit adds to the stress! Journal of Diabetes Science and Technology 6(1): 37-47, January 2012.

Srinivasan V: Nutritional implications of disorders. Comprehensive Critical Care: Pediatric, 2nd edition. Stockwell JA, Preissig CM (eds.). Society of Critical Care Medicine, Mount Prospect, IL, 2016 Notes: Chapter.

Rake AJ, Srinivasan V, Nadkarni V, Kaptan R, Newth CJ: Glucose variability and survival in critically ill children: allostasis or harm? Pediatric Critical Care Medicine 11(6): 707-712, November 2010.

Srinivasan V, Spinella PC, Drott HR, Roth CL, Helfaer MA, Nadkarni VM: Association of timing, duration and intensity of hyperglycemia with ICU mortality in critically ill children. Pediatric Critical Care Medicine 5(4): 329-336, July 2004 Notes: Featured CME Article.

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Last updated: 12/02/2016
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