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Vijay Srinivasan, MD

Vijay Srinivasan, MD

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Assistant Professor of Anesthesiology and Critical Care at the Hospital of the University of Pennsylvania and the Children's Hospital of Philadelphia
Department: Anesthesiology and Critical Care

Contact information
Department of Anesthesiology and Critical Care Medicine
The Children's Hospital of Philadelphia
34th Street and Civic Center Boulevard
Philadelphia, PA 19104-4399
Office: 215-590-5505
Fax: 215-590-4327
All-India Institute of Medical Sciences, New Delhi, India, 1995.
MD (Pediatrics)
All-India Institute of Medical Sciences, New Delhi, India, 1998.
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Description of Clinical Expertise

Dr. Srinivasan is a full-time attending physician at the Pediatric Intensive Care Unit (PICU) and Progressive Care Unit (PCU) at CHOP. The PICU at CHOP is a 55-bed tertiary care medical/surgical unit with approximately 3700 admissions every year and serves the Delaware Valley region of south-eastern Pennsylvania and adjoining southern New Jersey with national international referrals. The PICU offers advanced modes of ventilation, nitric oxide therapy, surfactant therapy, continuous and intermittent renal replacement therapies, extracorporeal life support therapy and advanced modes of blood exchanges. The PICU offers an accredited 3 year fellowship program supervised by board-certified PICU faculty members. The PICU manages all patients with close input from multiple consulting services and sub-specialties.

Description of Research Expertise

Dr. Srinivasan is engaged in research in endocrinopathies and nutrition in critically ill children. He is a Co-Investigator (10% effort) and local site PI on the NHLBI funded Heart and Lung Failure - Pediatric Insulin Titration (HALF-PINT) study (NHLBI/HL107681 PI: Agus/Nadkarni) involving multiple PALISI sites. He is also site PI for the ancillary study Coagulation and Fibrinolysis - Pediatric Insulin Titration (CAF-PINT) with HALF-PINT. Locally, he studies the association of stress hyperglycemia/ blood glucose variability with key outcomes in the PICU population. Dr. Srinivasan also seeks to improve anthropometry measurements and delivery of enteral nutrition in the PICU population. He is PI of a CHOP CTRC supported study on measurement and validation of resting energy expenditure in children chronically mechanically ventilated via tracheostomy. He is collaborating with Dr. Katri Typpo (University of Arizona) to study the role of biomarkers of effects of enteral nutrition on intestinal epithelium (BEENIE) involving multiple PALISI sites as ancillary to the HALF-PINT study.

Selected Publications

Srinivasan, V, Agus MSD: Tight glucose control in critically ill children: a systematic review and meta-analysis. Pediatric Diabetes 15(2): 75-83, March 2014.

Roberts K, Srinivasan V, Niles DE, Eilvstjonn J, Tyler L, Boyle L, Bishnoi R, Ferry S, Nysaether J, Stavland M, Litman RS, Helfaer M, Nadkarni VM: Does change in thoracic impedance measured via defibrillator electrode pads accurately detect ventilation breaths in children? Resuscitation 81(11): 1544-1549, November 2010.

Rake AJ, Srinivasan V, Nadkarni V, Kaptan R, Newth CJ: Glucose variability and survival in critically ill children: allostasis or harm? Pediatric Critical Care Medicine 11(6): 707-712, November 2010.

Sutton RM, Niles D, Nysaether J, Stavland M, Thomas M, Ferry S, Bishnoi R, Litman R, Allen J, Srinivasan V, Berg RA, Nadkarni VM: Effect of residual leaning force on intrathoracic pressure during mechanical ventilation in children. Resuscitation 81(7): 857-860, July 2010.

Srinivasan V, Nadkarni VM, Carey SM, Helfaer MA, Berg RA, for the AHA National Registry of CPR investigators: Childhood obesity and survival following in-hospital pediatric cardiopulmonary resuscitation. Pediatrics 125(3): e481-e488, March 2010.

Srinivasan V, Morris M, Helfaer MA, Berg RA, Nadkarni VM; American Heart Association National Registry of CPR Investigators: Calcium use during in-hospital pediatric cardiac arrest: A report from the National Registry of Cardiopulmonary Resuscitation. Pediatrics 121(5): e1144-e1151, May 2008.

Srinivasan V, Nadkarni FM, Yannopoulos D, Marino BS, Sigurdsson G, McKnite S, Zook M, Benditt D, Lurie K: Spontaneous gasping decreases intracranial pressure and improves cerebral perfusion in a pig model of ventricular fibrillation. Resuscitation 69(2): 329-334, May 2006.

Srinivasan V, Nadkarni VM, Yannopoulos D, Marino BS, Sigurdsson G, McKnite S, Zook M, Benditt D, Lurie K: Induction of cerebral hypothermia is enhanced with active compression-decompression plus inspiratory impedance threshold device CPR in a porcine model of cardiac arrest. Journal American College of Cardiology 47(4): 835-841, February 2006.

Srinivasan V, Spinella PC, Drott HR, Roth CL, Helfaer MA, Nadkarni VM: Association of timing, duration and intensity of hyperglycemia with ICU mortality in critically ill children. Pediatric Critical Care Medicine 5(4): 329-336, July 2004 Notes: Featured CME Article.

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Last updated: 12/08/2014
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