David J Steger, PhD

faculty photo
Research Assistant Professor of Medicine
Department: Medicine

Contact information
Smilow Center for Translational Research, 12-103
3400 Civic Center Boulevard
Philadelphia, PA 19104
Education:
BS (Biochemistry)
University of Wisconsin, Madison, WI, 1987.
PhD (Neuroscience)
University of California, San Diego, CA, 1993.
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Selected Publications

Emmett Matthew J, Lim Hee-Woong, Jager Jennifer, Richter Hannah J, Adlanmerini Marine, Peed Lindsey C, Briggs Erika R, Steger David J, Ma Tao, Sims Carrie A, Baur Joseph A, Pei Liming, Won Kyoung-Jae, Seale Patrick, Gerhart-Hines Zachary, Lazar Mitchell A: Histone deacetylase 3 prepares brown adipose tissue for acute thermogenic challenge. Nature 546(7659): 544-548, Jun 2017.

Soccio Raymond E, Li Zhenghui, Chen Eric R, Foong Yee Hoon, Benson Kiara K, Dispirito Joanna R, Mullican Shannon E, Emmett Matthew J, Briggs Erika R, Peed Lindsey C, Dzeng Richard K, Medina Carlos J, Jolivert Jennifer F, Kissig Megan, Rajapurkar Satyajit R, Damle Manashree, Lim Hee-Woong, Won Kyoung-Jae, Seale Patrick, Steger David J, Lazar Mitchell A: Targeting PPARγ in the epigenome rescues genetic metabolic defects in mice. The Journal of clinical investigation 127(4): 1451-1462, Apr 2017.

Jager Jennifer, Wang Fenfen, Fang Bin, Lim Hee-Woong, Peed Lindsey C, Steger David J, Won Kyoung-Jae, Kharitonenkov Alexei, Adams Andrew C, Lazar Mitchell A: The Nuclear Receptor Rev-erbα Regulates Adipose Tissue-specific FGF21 Signaling. The Journal of biological chemistry 291(20): 10867-75, May 2016.

Bauer Robert C, Sasaki Makoto, Cohen Daniel M, Cui Jian, Smith Mikhaila A, Yenilmez Batuhan O, Steger David J, Rader Daniel J: Tribbles-1 regulates hepatic lipogenesis through posttranscriptional regulation of C/EBPα. The Journal of clinical investigation 125(10): 3809-18, Oct 2015.

Soccio Raymond E, Chen Eric R, Rajapurkar Satyajit R, Safabakhsh Pegah, Marinis Jill M, Dispirito Joanna R, Emmett Matthew J, Briggs Erika R, Fang Bin, Everett Logan J, Lim Hee-Woong, Won Kyoung-Jae, Steger David J, Wu Ying, Civelek Mete, Voight Benjamin F, Lazar Mitchell A: Genetic Variation Determines PPARγ Function and Anti-diabetic Drug Response In Vivo. Cell 162(1): 33-44, Jul 2015.

Lim Hee-Woong, Uhlenhaut N Henriette, Rauch Alexander, Weiner Juliane, Hübner Sabine, Hübner Norbert, Won Kyoung-Jae, Lazar Mitchell A, Tuckermann Jan, Steger David J: Genomic redistribution of GR monomers and dimers mediates transcriptional response to exogenous glucocorticoid in vivo. Genome research 25(6): 836-44, Jun 2015.

Cohen Daniel M, Won Kyoung-Jae, Nguyen Nha, Lazar Mitchell A, Chen Christopher S, Steger David J: ATF4 licenses C/EBPβ activity in human mesenchymal stem cells primed for adipogenesis. eLife 4: e06821, Jun 2015.

Zhang Yuxiang, Fang Bin, Emmett Matthew J, Damle Manashree, Sun Zheng, Feng Dan, Armour Sean M, Remsberg Jarrett R, Jager Jennifer, Soccio Raymond E, Steger David J, Lazar Mitchell A: GENE REGULATION. Discrete functions of nuclear receptor Rev-erbα couple metabolism to the clock. Science (New York, N.Y.) 348(6242): 1488-92, Jun 2015.

Harms Matthew J, Lim Hee-Woong, Ho Yugong, Shapira Suzanne N, Ishibashi Jeff, Rajakumari Sona, Steger David J, Lazar Mitchell A, Won Kyoung-Jae, Seale Patrick: PRDM16 binds MED1 and controls chromatin architecture to determine a brown fat transcriptional program. Genes & development 29(3): 298-307, Feb 2015.

Step Sonia E, Lim Hee-Woong, Marinis Jill M, Prokesch Andreas, Steger David J, You Seo-Hee, Won Kyoung-Jae, Lazar Mitchell A: Anti-diabetic rosiglitazone remodels the adipocyte transcriptome by redistributing transcription to PPARγ-driven enhancers. Genes & development 28(9): 1018-28, May 2014.

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Last updated: 09/21/2017
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