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Hao Shen, PH.D.

Hao Shen, Ph.D.

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Associate Professor of Microbiology
Department: Microbiology
Graduate Group Affiliations

Contact information
303D Johnson Pavilion
3610 Hamilton Walk
Philadelphia, PA 19104
Office: (215) 573-5259
Fax: (215) 573-9068
Lab: 215-898-6586
Education:
B.S.
Jiangxi University, China, 1983.
Ph.D.
University of California at Riverside, 1992.
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Description of Research Expertise

Research Interests
Immune surveillance of intracelluar and emerging infectious agents.

Key words: Listeria, Ebola, T lymphocyte, bacterial pathogenesis, vaccine.

Description of Research
We have a long-standing interest in basic questions related to generation of effective immune responses, mechanisms of protective immunity, and the establishment of long-term immunological memory. For these basic studies, we have used two well-characterized murine models of infection with lymphocytic choriomeningitis virus (LCMV) and Listeria monocytogenes. More recently, we have become interested in viral/bacterial co-infections, which occur frequently in clinics and often results in more severe disease than infection by an individual pathogen. A striking example of this is the high mortality caused by secondary bacterial pneumonia following flu infection. We are studying how inflammation induced by a bacterial pathogen may affect the host response to a co-infecting viral pathogen and protective immunity. We are investigating the mechanisms of bacterial pathogenesis that contribute to lethal secondary bacterial pneumonia following flu infection. Through these studies, we have gained new insights into complexity of tripartite interactions between the virus, bacterium and host immune system. We are developing novel, combinational vaccine approaches tailored towards co-infection.

Selected Publications

Listeria monocytogenes: pathogenesis and host resopnse. H. Goldfine and H. Shen (eds.). Springer Publisher, 2005.

Zenewicz LA, Skinner JA, Goldfine H, Shen H : Listeria monocytogenes Virulence Proteins Induce Surface Expression of Fas Ligand on T lymphocytes. Molecular Microbiology 51(5): 1483-1492, March 2004.

Chua MM, Macnamara K, San Mateo LR, Shen H, Weiss SR: Effects of an epitope specific CD8+ T cell response on murine coronavirus CNS disease: protection from virus replication and antigen spread and selection of epitope escape mutants. Journal of Virology 78(3): 1150-1159, February 2004.

Nichols KE, Haines K, Myung PS, Newbrough S, Myers E, Jumaa H, Shedlock DJ, Shen H, Ahmed J, Ali H, Koretzky GA: Macrophage activation and Fc-receptor-mediated signaling do not require expression of the SLP-76 and SLP-65 adaptors. J. Leuk Biol. 75(3): 541-552, March 2004.

Simmons G, Lee A, Rennekamp AJ, Fan X, Bates P, Shen H: Identification of murine T cell epitopes in Ebola virus nucleoprotein. Virology 318(1): 224-230, January 2004.

Starks H, Bruhn KW, Shen H, Barry RA, Dubensky TW, Brockstedt D, Hinrichs DJ, Higgin DE, Miller JF, Giedlin M, Bouwer HGA: Listeria monocytogenes as a vaccine vector: virulence attenuation or existing anti-vector immunity does not diminish therapeutic efficacy. Journal Immunology 173(1): 420-427, July 2004.

Skinner, J., Reissinger A, Shen H, Yuk M: Bordetella type III secretion and adenylate cyclase toxin synergize to drive dendritic cells into a semi-mature state. Journal of Immunology 173(3): 1934-1940, August 2004.

Pearce El, Shedlock DJ, Shen H: Functional characterization of MHC Class II-Restricted CD8+CD4- and CD8-CD4- T Cell Responses to Infection in CD4-/- Mice. Journal of Immunology 173(4): 2494-2499, August 2004.

Zheng S, Jiang J, Shen H and Chen Y: Reduced apoptosis and listeriosis in TRIAL-null mice. Journal of Immunology 173(9): 5652-5658, November 2004.

Northrop JC, Shen H: CD8+ T-cell memory: only the good ones last. Curr Opin Immunol 16(4): 451-455, August 2004.

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Last updated: 02/04/2014
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