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Carlo Ballatore, Ph.D.

Carlo Ballatore, Ph.D.

faculty photo
Research Associate Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine

Contact information
University of Pennsylvania
231 South 34th Street
Philadelphia, Pa 19104
Education:
BS/MS (Chemistry and Pharmaceutical Technologies)
University of Rome "La Sapienza", 1995.
Ph.D. (Medicinal Chemistry)
Cardiff University, Welsh School of Pharmacy , 2001.
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Selected Publications

Alex Crowe, Michael James, Virginia M.-Y. Lee, Amos B. Smith, John Q. Trojanowski, Carlo Ballatore, Kurt R. Brunden: Aminothienopyridazines and Methylene Blue affect Tau Fibrillization via Cysteine Oxidation. Journal of Biological Chemistry 288(16): 11024-37, 2013.

V. La Pietra, G. La Regina, A. Coluccia, V. Famiglini, S. Pelliccia, B. Plotkin, H. Eldar-Finkelman, A. Brancale, C. Ballatore, A. Crowe, K. R. Brunden, L. Marinelli, E. Novellino, R. Silvestri: Design, Synthesis, and Biological Evaluation of 1-Phenylpyrazolo[3,4-e]pyrrolo[3,4-g]indolizine-4,6(1H,5H)-diones as New Glycogen Synthase Kinase-3β Inhibitors. Journal of Medicinal Chemistry 56: 10066-78. 2013.

Kurt R Brunden, Nicola M Gardner, Michael J James, Yuemang Yao, John Q Trojanowski, Virginia M.-Y. Lee, Ian Paterson, Carlo Ballatore, and Amos B Smith: The MT-Stabilizer, Dictyostatin, Exhibits Prolonged Brain Retention and Activity: Potential Therapeutic Implications. ACS Medicinal Chemistry Letters DOI: 10.1021/ml400233e, 2013.

B. Zhang, B., Carroll, J., Trojanowski, J.Q., Yao, Y., Potuzak, J.S., Hogan, A.-M.L., Xie, S., Ballatore, C., Smith, A.B. III, Lee, V. M.-Y., Brunden, K.R.: The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, cognitive deficits and Alzheimer's like pathology in tau transgenic mice after disease onset. Journal of Neuroscience 2012.

Soper, J. H., Sugiyama, S., Herbst-Robinson, K., James, M. J., Wang, X., Trojanowski, J. Q., Smith A. B. III, Lee, V. M.-Y., Ballatore, C., Brunden, K. R.: Brain-Penetrant Tetrahydronaphthalene Thromboxane A2-Prostanoid (TP) Receptor Antagonists as Prototype Therapeutics for Alzheimer’s Disease. ACS Chemical Neuroscience. American Chemical Society, 3(11): 928-940, 2012.

Ballatore, C., Crowe, A., Piscitelli, F., James, M., Lou, K., Rossidivito, G., Yao, Y., Trojanowski, J. Q., Lee, V. M.-Y., Brunden, K. R., Smith, A. B. III: Aminothienopyridazine Inhibitors of Tau Aggregation: Evaluation of Structure-Activity Relationship Leads to Selection of Candidates with Desirable In Vivo Properties. Bioorganic & Medicinal Chemistry. Elsevier, 20: 4451–61, 2012.

Ballatore, C., Soper, J., Piscitelli, F., James, M., Huang, L., Atasoylu, O., Huryn, D. M., Trojanowski, J. Q., Lee, V. M.-Y., Brunden, K. R., Smith, A. B. III: Cyclopentane-1,3-dione: a novel isostere for the carboxylic acid functional group. Application to the design of potent thromboxane (A2)-receptor antagonists. Journal of Medicinal Chemistry. ACS, 54: 6969–83, 2011.

Brunden, K. R., Yao, Y., Potuzak, J. S., Ibarz Ferrer, N., Ballatore, C., James, M. J., Hogan, A.M., Trojanowski, J.Q., Smith, III, Lee, V. M.-Y.: The characterization of microtubule-stabilizing drugs as possible therapeutic agents for Alzheimer’s disease and related tauopathies. Neurobiology of Disease 63: 341, 2011.

Piscitelli, F., Ballatore, C., Smith, A.B. III: Solid phase synthesis of 2-aminobenzothiazoles Bioorganic & Medicinal Chemistry Letters 20: 644, 2010.

Brunden, K. R., Zhang, B., Carrol, J., Yao, Y., Potuzak, J., Hogan, A-M., Iba, M., James, M., Xie, S., Ballatore, C., Smith, A. B. III, Lee, V. M.-Y., Trojanowski, J. Q.: Epothilone D improves microtubule density, axonal integrity and cognition in a transgenic mouse model of tauopathy. Journal of Neuroscience 30: 13861-66, 2010.

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Last updated: 04/18/2014
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