Carlo Ballatore, Ph.D.
Carlo Ballatore, Ph.D.
Research Assistant Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine
Contact information
University of Pennsylvania
231 South 34th Street
Philadelphia, Pa 19104
231 South 34th Street
Philadelphia, Pa 19104
Email:
bcarlo@sas.upenn.edu
bcarlo@sas.upenn.edu
Education:
BS/MS (Chemistry and Pharmaceutical Technologies)
University of Rome "La Sapienza", 1995.
Ph.D. (Medicinal Chemistry)
Cardiff University, Welsh School of Pharmacy , 2001.
Permanent linkBS/MS (Chemistry and Pharmaceutical Technologies)
University of Rome "La Sapienza", 1995.
Ph.D. (Medicinal Chemistry)
Cardiff University, Welsh School of Pharmacy , 2001.
Selected Publications
B. Zhang, B., Carroll, J., Trojanowski, J.Q., Yao, Y., Potuzak, J.S., Hogan, A.-M.L., Xie, S., Ballatore, C., Smith, A.B. III, Lee, V. M.-Y., Brunden, K.R.: The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, cognitive deficits and Alzheimer's like pathology in tau transgenic mice after disease onset. Journal of Neuroscience 2012.Soper, J. H., Sugiyama, S., Herbst-Robinson, K., James, M. J., Wang, X., Trojanowski, J. Q., Smith A. B. III, Lee, V. M.-Y., Ballatore, C., Brunden, K. R.: Brain-Penetrant Tetrahydronaphthalene Thromboxane A2-Prostanoid (TP) Receptor Antagonists as Prototype Therapeutics for Alzheimer’s Disease. ACS Chemical Neuroscience. American Chemical Society, in press, 2012.
Ballatore, C., Crowe, A., Piscitelli, F., James, M., Lou, K., Rossidivito, G., Yao, Y., Trojanowski, J. Q., Lee, V. M.-Y., Brunden, K. R., Smith, A. B. III: Aminothienopyridazine Inhibitors of Tau Aggregation: Evaluation of Structure-Activity Relationship Leads to Selection of Candidates with Desirable In Vivo Properties. Bioorganic & Medicinal Chemistry. Elsevier, 20: 4451–61, 2012.
Ballatore, C., Soper, J., Piscitelli, F., James, M., Huang, L., Atasoylu, O., Huryn, D. M., Trojanowski, J. Q., Lee, V. M.-Y., Brunden, K. R., Smith, A. B. III: Cyclopentane-1,3-dione: a novel isostere for the carboxylic acid functional group. Application to the design of potent thromboxane (A2)-receptor antagonists. Journal of Medicinal Chemistry. ACS, 54: 6969–83, 2011.
Brunden, K. R., Yao, Y., Potuzak, J. S., Ibarz Ferrer, N., Ballatore, C., James, M. J., Hogan, A.M., Trojanowski, J.Q., Smith, III, Lee, V. M.-Y.: The characterization of microtubule-stabilizing drugs as possible therapeutic agents for Alzheimer’s disease and related tauopathies. Neurobiology of Disease 63: 341, 2011.
Piscitelli, F., Ballatore, C., Smith, A.B. III: Solid phase synthesis of 2-aminobenzothiazoles Bioorganic & Medicinal Chemistry Letters 20: 644, 2010.
Ballatore, C., Brunden, K. R., Piscitelli, F., James, M., Crowe, A., Yao, M., Hyde, E., Trojanowski, J. Q., Lee, V. M.-Y., Smith, A. B. III: Discovery of brain-penetrant and orally bioavailable aminothienopyridazine inhibitors of tau aggregation. Journal of Medicinal Chemistry. ACS, 53: 3739–3747, 2010.
Brunden, K. R., Zhang, B., Carrol, J., Yao, Y., Potuzak, J., Hogan, A-M., Iba, M., James, M., Xie, S., Ballatore, C., Smith, A. B. III, Lee, V. M.-Y., Trojanowski, J. Q.: Epothilone D improves microtubule density, axonal integrity and cognition in a transgenic mouse model of tauopathy. Journal of Neuroscience 30: 13861-66, 2010.
Crowe, A., Huang, W. Ballatore, C., Johnson, R. L., Hogan, A.-M. L., Huang, R., Wichtermann, J., McCoy, J., Huryn, D., Auld, D. S., Smith, A. B. III, Inglese, J., Trojanowski, J. Q., Austin, C. P., Brunden, K. R., Lee, V. M.-Y.: The Identification of Aminothienopyridazine Inhibitors of Tau Assembly by Quantitative High-Throughput Screening. Biochemistry 2009.
Ballatore, C., Zhang, B., Trojanowski, J. Q., Lee, V. M., Smith, A. B., 3rd: In situ blood-brain barrier permeability of a C-10 paclitaxel carbamate. Bioorganic & Medicinal Chemistry Letters 18(23): 6119-21, 2008.