Mark E. Mikkelsen, MD, MSCE, FCCM

faculty photo
Associate Professor of Medicine at the Hospital of the University of Pennsylvania
Department: Medicine

Contact information
Gates 05042
3400 Spruce Street
Hospital of the University of Pennsylvania
Philadelphia, PA 19104
Office: (215) 615-5416
Fax: (215) 614-0869
Lab: (267) 285-6602
BA (Political Science)
Colgate University, Hamilton, NY, 1996.
(Post-Baccalaureate Pre-Medical Degree Program)
Bryn Mawr College, Bryn Mawr, PA, 1997.
MD (Medical Degree)
University of Virginia School of Medicine, Charlottesville, VA, 2002.
MSCE (Clinical Epidemiology and Biostatistics)
University of Pennsylvania, Philadelphia, PA, 2008.
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Description of Research Expertise

Dr. Mikkelsen is the Chief of the Section of Medical Critical Care at Penn. He serves as Co-Chair of the UPHS Critical Care Committee and Medical Director of the Penn Presbyterian Medical Intensive Care Unit. Through these efforts, he supports the growth and development of a phenomenal group of multidisciplinary Penn providers who are collectively driven to educate the next generation of critical care clinicians, to deliver care of the highest quality to the critically ill, and to create and implement innovative science that advances the field of critical care medicine.

Research Program:
Through the lens of the patient and their family, Dr. Mikkelsen conducts patient-oriented research focused on sepsis, acute respiratory distress syndrome, and long-term outcomes in survivors of critical illness. He is passionate in his goal to improve the delivery of care to critically ill patients and to improve the lives of survivors of critical illness by understanding how critical illness impacts one's life and one's health trajectory.

Dr. Mikkelsen encourages colleagues, as well as survivors of critical illness and their loved ones, who are committed to improving the quality of care delivered to critically ill patients to contact him at Together, we can "be the difference."

Description of Clinical Expertise

Dr. Mikkelsen's philosophy for patient care is to ensure that exceptional, compassionate care is delivered to critically ill patients and their family members through outstanding, multi-disciplinary teamwork across the continuum of care, through the application of evidence-based care, and through systematic study to optimize our performance. Dr. Mikkelsen is an expert in critical care medicine, and the devastating syndromes of sepsis, acute respiratory distress syndrome, and post-intensive care syndrome specifically.

Dr. Mikkelsen partners with state and national government agencies to improve care delivery for the critically ill. He serves as Co-Chair of the Society of Critical Care Medicine's Thrive: Supporting Survivors of Critical Illness Initiative, Chair of the SCCM Internal Medicine Section, and was Co-Chair of the 2018 SCCM Congress in San Antonio, Texas. He also serves on the American Thoracic Society's Quality Improvement and Implementation Committee.

Selected Publications

Anderson BJ, Mikkelsen ME: A new direction: sleep and neuropsychological impairment after critical illness. Ann Am Thorac Soc 15(1): 114, 2018.

McPeake J, Mikkelsen ME: The evolution of post-intensive care syndrome. Crit Care Med 2018 Notes: In press.

Meyer N, Harhay MO, Small DS, Prescott HC, Bowles KH, Gaieski DF, Mikkelsen ME: Temporal trends in incidence, sepsis-related mortality, and hospital-based acute care after sepsis. Crit Care Med 2018 Notes: In press.

Sepsis Alliance and Society of Critical Care Medicine: Life after sepsis Sepsis Alliance, SCCM and YouTube 2018 Notes: Co-designed informational video for sepsis survivors and caregivers.

Martin N, Pascual JL, Crowe D, Toevs C, Cereda MF, Mikkelsen M, Kaplan LJ: Comfort at the crossroads: service, therapy and emotional support animals in the ICU and at the end-of-life J Trauma Acute Care Surg 2018 Notes: In press.

Detsky ME, Harhay MO, Bayard DF, Delman AM, Buehler AE, Kent SA, Ciuffetelli IV, Cooney E, Gabler NB, Ratcliffe SJ, Mikkelsen ME, Halpern SD: Discriminative accuracy of physician and nurse predictions for survival and functional outcomes 6 months after an ICU admission. JAMA May 2017 Notes: Early on line May 21, 2017.

Dietz B, Jones TK, Small DS, Gaieski DF, Mikkelsen ME: The relationship between index hospitalizations, sepsis, and death or transition to hospice care during 30-day hospital readmissions. Med Care 55(4): 362-370, Apr 2017.

Johnson N, Dodampahala K, Rosselot R, Perman S, Mikkelsen ME, Goyal M, Gaieski DF, Grossestreuer AV : The association between arterial oxygen tension and neurological outcome after cardiac arrest. Ther Hypothermia Temp Manag 7(1): 36-41, Mar 2017.

Gutsche JT, Mikkelsen ME, McCarthy FH, Miano TM, Vernick WJ, Ramakrishna H, Patel PA, Augoustides Y, Szeto WY, Desai ND, Lane-Fall MB, Williams ML: Veno-venous extracorporeal life support in hemodynamically unstable patients with ARDS. Anesth Analg 124(3): 846-848, Mar 2017.

Mikkelsen ME: Triangulating weakness, morbidity, and mortality amongst ARDS survivors: a story emerges. Crit Care Med 45(2): 370-371, Feb 2017 Notes: Editorial.

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Last updated: 05/15/2018
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