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Nicole Alyse Aqui, M.D.

Nicole Alyse Aqui, M.D.

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Assistant Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania
Department: Pathology and Laboratory Medicine

Contact information
409B Stellar Chance Laboratories
422 Curie Blvd.
Philadelphia, PA 19104
Office: 215-746-1195
Fax: 215-746-1100
Education:
B.S. (Cellular and Molecular Biology)
University of Maryland College Park, 1996.
M.D. (Medicine)
University of Pennsylvania School of Medicine, 2001.
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Description of Research Expertise

Immune assessment, immune recovery, adoptive T cell immunotherapy, multiple myeloma

Description of Clinical Expertise

Transfusion medicine, multiple myeloma, stem cell transplant, apheresis

Selected Publications

Rapoport Aaron P, Aqui Nicole A, Stadtmauer Edward A, Vogl Dan T, Fang Hong-Bin, Cai Ling, Janofsky Stephen, Chew Anne, Storek Jan, Akpek Gorgun, Badros Ashraf, Yanovich Saul, Tan Ming T, Veloso Elizabeth, Pasetti Marcela F, Cross Alan, Philip Sunita, Murphy Heather, Bhagat Rita, Zheng Zhaohui, Milliron Todd, Cotte Julio, Cannon Andrea, Levine Bruce L, Vonderheide Robert H, June Carl H: Combination immunotherapy using adoptive T-cell transfer and tumor antigen vaccination on the basis of hTERT and survivin after ASCT for myeloma. Blood 117(3): 788-97, Jan 2011.

Stadtmauer Edward A, Vogl Dan T, Luning Prak Eline, Boyer Jean, Aqui Nicole A, Rapoport Aaron P, McDonald Kenyetta R, Hou Xiaoling, Murphy Heather, Bhagat Rita, Mangan Patricia A, Chew Anne, Veloso Elizabeth A, Levine Bruce L, Vonderheide Robert H, Jawad Abbas F, June Carl H, Sullivan Kathleen E: Transfer of influenza vaccine-primed costimulated autologous T cells after stem cell transplantation for multiple myeloma leads to reconstitution of influenza immunity: results of a randomized clinical trial. Blood 117(1): 63-71, Jan 2011.

N. Aqui, L. Leinbach, E. A. Chong, T. Ahmadi, J. Svoboda, A. Gordon, L. H. Downs, S. Nasta, S. J. Schuster: Changes in regulatory T-cells in responding and non-responding patients with indolent B-cell or mantle cell lymphomas during treatment with lenalidomide, dexamethasone, and rituximab. J Clin Oncol 28(suppl; abstr 8085): 7s, 2010.

Rapoport Aaron P, Stadtmauer Edward A, Aqui Nicole, Vogl Dan, Chew Anne, Fang Hong-Bin, Janofsky Stephen, Yager Kelly, Veloso Elizabeth, Zheng Zhaohui, Milliron Todd, Westphal Sandra, Cotte Julio, Huynh Hong, Cannon Andrea, Yanovich Saul, Akpek Gorgun, Tan Ming, Virts Kristen, Ruehle Kathleen, Harris Carolynn, Philip Sunita, Vonderheide Robert H, Levine Bruce L, June Carl H: Rapid immune recovery and graft-versus-host disease-like engraftment syndrome following adoptive transfer of Costimulated autologous T cells. Clinical Cancer Research 15(13): 4499-507, Jul 2009.

Aqui NA, June CH: Post-transplant adoptive T-cell immunotherapy. Best Pract Res Clin Haematol 21(3): 503-519, 2008.

Golovina T, Mikheeva T, Suhoski MM, Aqui NA, Tai VC, Shan X, Liu R, Balcarcel RR, Fisher N, Levine BL, Carroll RG, Blazar BR, June CH, Riley JL: CD28 Costimulation is essential for human T regulatory expansion and function. Journal of Immunology 181(4): 2855-2868, Aug 2008.

Suhoski M, Golovina T, Aqui NA, Tai V, Varela-Rohena A, Milone MC, Carroll RG, Riley J, June CH: Engineering artificial antigen presenting cells to express a diverse array of costimulatory molecules. Molecular Therapy 15(5): 981-988, May 2007.

Patel H, Vogl DT, Aqui N, Shaked A, Olthoff K, Markmann J, Reddy R, Stadtmauer EA, Schuster SJ, Tsai DE: Posttransplant lymphoproliferative disorder in liver transplant recipients: A report of seventeen cases. Leukemia and Lymphoma 48(5): 885-891, May 2007.

Elstrom RL, Andreadis C, Aqui NA, Ahya VN, Bloom RD, Brozena SC, Olthoff KM, Schuster SJ, Nasta SD, Stadtmauer EA, Tsai DE: Treatment of PTLD with rituximab or chemotherapy. American Journal of Transplantation 6(3): 569-576, March 2006.

Rapoport AP*, Stadtmauer EA*, Aqui NA*, Badros A, Cotte J, Chrisley L, Veloso E, Zheng Z, Westphal S, Mair R, Chi N, Ratterree B, Pochran MF, Natt S, Hinkle J, Sickles C, Sohal A, Ruehle K, Lynch C, Zhang L, Porter DL, Luger S, Guo C, Fang HB, Blackwelder W, Hankey K, Mann D, Edelman R, Frasch C, Levine BL, Cross A, June CH: Restoration of immunity in lymphopenic individuals with cancer by vaccination and adoptive T-cell transfer. Nature Medicine 11(11): 1230-1237, Nov 2005.

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Last updated: 04/16/2014
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