Albert M. Maguire, MD
Albert M. Maguire, MD
Associate Professor of Ophthalmology at the Hospital of the University of Pennsylvania and the Presbyterian Medical Center of Philadelphia
Department: Ophthalmology
Contact information
Scheie Eye Institute
Department of Ophthalmology
University of Pennsylvania
51 North 39th Street
Philadelphia, PA 19104
Department of Ophthalmology
University of Pennsylvania
51 North 39th Street
Philadelphia, PA 19104
Email:
amaguire@mail.med.upenn.edu
amaguire@mail.med.upenn.edu
Education:
B.A.
Princeton University, 1982.
M.D.
Harvard University, 1986.
Permanent linkB.A.
Princeton University, 1982.
M.D.
Harvard University, 1986.
Description of Research Expertise
Gene therapy for retinal degeneration, gene therapy for ocular neovascularization, Subretinal surgeryDescription of Clinical Expertise
diabetic retinopathy, retinopathy of prematurity, macular degeneration, sickle cell disease, gene therapy, retinal degenerationSelected Publications
Ashtari M, Cyckowski LL, Monroe JF, Marshall KA, Chung DC, Auricchio A, Simonelli F, Leroy BP, Maguire AM, Shindler K, Bennett J.: The human visual cortex responds to gene therapy–mediated recovery of retinal function. J Clin Invest. 121(6): 2160-8, June 2011 Notes: doi: 10.1172/JCI57377. Epub 2011 May 23.Vandenberghe LH, Bell P, Maguire AM, Cearley CN, Xiao R, Calcedo R, Wang L, Castle MJ, Maguire AC, Grant R, Wolfe JH, Wilson JM, Bennett J.: Dosage thresholds for AAV2 and AAV8 photoreceptor gene therapy in monkey. Sci Transl Med. 3(88): 88ra54, June 2011.
Amado D, Mingozzi F, Hui D, Bennicelli JL, Wei Z, Chen Y, Bote E, Grant RL, Golden JA, Narfstrom K, Syed NA, Orlin SE, High KA, Maguire AM, Bennett J.: Safety and efficacy of subretinal readministration of a viral vector in large animals to treat congenital blindness. Sci Transl Med. 2(21): 21ra16, March 2010.
Chung DC, Lee V, Maguire AM.: Recent advances in ocular gene therapy. Curr Opin Ophthalmol. 20(5): 377-81, September 2009.
Maguire AM, Simonelli F, Pierce EA, Pugh EN Jr, Mingozzi F, Bennicelli J, Banfi S, Marshall KA, Testa F, Surace EM, Rossi S, Lyubarsky A, Arruda VR, Konkle B, Stone E, Sun J, Jacobs J, Dell'Osso L, Hertle R, Ma JX, Redmond TM, Zhu X, Hauck B, Zelenaia O, Shindler KS, Maguire MG, Wright JF, Volpe NJ, McDonnell JW, Auricchio A, High KA, Bennett J.: Safety and efficacy of gene transfer for Leber's congenital amaurosis. N Engl J Med. 358(21): 2240-8, May 2008 Notes: Epub 2008 Apr 27.
Allocca M, Doria M, Petrillo M, Colella P, Garcia-Hoyos M, Gibbs D, Kim SR, Maguire A, Rex TS, Di Vicino U, Cutillo L, Sparrow JR, Williams DS, Bennett J, Auricchio A.: Serotype-dependent packaging of large genes in adeno-associated viral vectors results in effective gene delivery in mice. J Clin Invest. 118(5): 1955-64, May 2008.
Lebherz C, Maguire A, Tang W, Bennett J, Wilson JM.: Novel AAV serotypes for improved ocular gene transfer. J Gene Med. 10(4): 375-82, April 2008.
Bennicelli J, Wright JF, Komaromy A, Jacobs JB, Hauck B, Zelenaia A, Mingozzi F, Hui D, Chung D, Rex TS, Wei Z, Qu G, Zhou S, Zeiss C, Arruda VR, Acland GM, Dell'Osso LF, High KA, Maguire AM, Bennett J: Reversal of blindness in animal models of Leber's congenital amaurosis using optimized AAV2-mediated gene transfer. Mol Ther. 16(3): 458-65, March 2008.
Fox RJ, Costello F, Judkins AR, Galetta SL, Maguire AM, Leonard B, Markowitz CE.: Treatment of Susac syndrome with gamma globulin and corticosteroids. J Neurol Sci. 251(1-2): 17-22, December 2006 Notes: Epub 2006 Oct 17.
Jacobson SG, Boye SL, Aleman TS, Conlon TJ, Zeiss CJ, Roman AJ, Cideciyan AV, Schwartz SB, Komaromy AM, Doobrajh M, Cheung AY, Sumaroka A, Pearce-Kelling SE, Aguirre GD, Kaushal S, Maguire AM, Flotte TR, Hauswirth WW.: Safety in nonhuman primates of ocular AAV2-RPE65, a candidate treatment for blindness in Leber congenital amaurosis. Hum Gene Ther. 17(8): 845-58, August 2006.