John B. Hogenesch, Ph.D.
John B. Hogenesch, Ph.D.
Associate Professor of Pharmacology
Department: Pharmacology
Graduate Group Affiliations
Contact information
810 BRB
421 Curie Blvd.
Philadelphia, PA 19104-6160
421 Curie Blvd.
Philadelphia, PA 19104-6160
Office: 484-842-4232
Email:
hogenesc@mail.med.upenn.edu
hogenesc@mail.med.upenn.edu
Links
Hogenesch Lab Homepage
Faculty Profile, Department of Pharmacology, University of Pennsylvania School of Medicine
Hogenesch Lab Homepage
Faculty Profile, Department of Pharmacology, University of Pennsylvania School of Medicine
Education:
B.A. (History)
University of Southern California, 1989.
B.S. (Biology)
University of Southern California, 1991.
Ph.D. (Neuroscience)
Northwestern University, 1999.
Permanent linkB.A. (History)
University of Southern California, 1989.
B.S. (Biology)
University of Southern California, 1991.
Ph.D. (Neuroscience)
Northwestern University, 1999.
Description of Research Expertise
Our laboratory studies the mammalian circadian clock using genomic and computational tools. We use these tools to discover new clock genes, learn how the clock keeps time, and how it coordinates rhythms in physiology and behavior. This clock research drives development of genomic and computational methods that we apply to other areas of biology. Finally, we recognize biological complexity and conduct this research at the network, rather than single gene, level.Selected Publications
Zhang EE, Liu AC, Hirota T, Miraglia LJ, Welch G, Pongsawakul PY, Liu X, Atwood A, Huss JW, Janes J, Su AI, Hogenesch JB, Kay SA: A Genome-wide RNAi Screen for Modifiers of the Circadian Clock in Human Cells. Cell Sep 2009.Hughes Michael E, DiTacchio Luciano, Hayes Kevin R, Vollmers Christopher, Pulivarthy S, Baggs Julie E, Panda Satchidananda, Hogenesch John B: Harmonics of circadian gene transcription in mammals. PLoS genetics 5(4): e1000442, Apr 2009.
Baggs Julie E, Price Tom S, DiTacchio Luciano, Panda Satchidananda, Fitzgerald Garret A, Hogenesch John B: Network features of the mammalian circadian clock. PLoS biology 7(3): e52, Mar 2009.
Warzecha Claude C, Sato Trey K, Nabet Behnam, Hogenesch John B, Carstens Russ P: ESRP1 and ESRP2 are epithelial cell-type-specific regulators of FGFR2 splicing. Molecular cell 33(5): 591-601, Mar 2009.
Hogenesch John B: It's all in a day's work: Regulation of DNA excision repair by the circadian clock. Proceedings of the National Academy of Sciences of the United States of America 106(8): 2481-2, Feb 2009.
Sato Trey K, Yamada Rikuhiro G, Ukai Hideki, Baggs Julie E, Miraglia Loren J, Kobayashi Tetsuya J, Welsh David K, Kay Steve A, Ueda Hiroki R, Hogenesch John B: Feedback repression is required for mammalian circadian clock function. Nature genetics 38(3): 312-9, Mar 2006.
Su Andrew I, Wiltshire Tim, Batalov Serge, Lapp Hilmar, Ching Keith A, Block David, Zhang Jie, Soden Richard, Hayakawa Mimi, Kreiman Gabriel, Cooke Michael P, Walker John R, Hogenesch John B: A gene atlas of the mouse and human protein-encoding transcriptomes. Proceedings of the National Academy of Sciences of the United States of America 101(16): 6062-7, Apr 2004.
Sato Trey K, Panda Satchidananda, Miraglia Loren J, Reyes Teresa M, Rudic Radu D, McNamara Peter, Naik Kinnery A, FitzGerald Garret A, Kay Steve A, Hogenesch John B: A functional genomics strategy reveals Rora as a component of the mammalian circadian clock. Neuron 43(4): 527-37, Aug 2004.
Panda Satchidananda, Provencio Ignacio, Tu Daniel C, Pires Susana S, Rollag Mark D, Castrucci Ana Maria, Pletcher Mathew T, Sato Trey K, Wiltshire Tim, Andahazy Mary, Kay Steve A, Van Gelder Russell N, Hogenesch John B: Melanopsin is required for non-image-forming photic responses in blind mice. Science (New York, N.Y.) 301(5632): 525-7, Jul 2003.
Panda Satchidananda, Antoch Marina P, Miller Brooke H, Su Andrew I, Schook Andrew B, Straume Marty, Schultz Peter G, Kay Steve A, Takahashi Joseph S, Hogenesch John B: Coordinated transcription of key pathways in the mouse by the circadian clock. Cell 109(3): 307-20, May 2002.