John B. Hogenesch, Ph.D.
John B. Hogenesch, Ph.D.
Associate Professor of Pharmacology
Department: Pharmacology
Graduate Group Affiliations
Contact information
Translational Research Center 10-124
3400 Civic Center Blvd., Bldg. 421
Philadelphia, PA 19104-5158
3400 Civic Center Blvd., Bldg. 421
Philadelphia, PA 19104-5158
Office: 484-842-4232
Email:
hogenesc@mail.med.upenn.edu
hogenesc@mail.med.upenn.edu
Links
Faculty Profile, Department of Pharmacology, Perelman School of Medicine at the University of Pennsylvania
Hogenesch Lab Homepage
Faculty Profile, Department of Pharmacology, Perelman School of Medicine at the University of Pennsylvania
Hogenesch Lab Homepage
Education:
B.A. (History)
University of Southern California, 1989.
B.S. (Biology)
University of Southern California, 1991.
Ph.D. (Neuroscience)
Northwestern University, 1999.
Permanent linkB.A. (History)
University of Southern California, 1989.
B.S. (Biology)
University of Southern California, 1991.
Ph.D. (Neuroscience)
Northwestern University, 1999.
Description of Research Expertise
Our laboratory studies the mammalian circadian clock using genomic and computational tools. We use these tools to discover new clock genes, learn how the clock keeps time, and how it coordinates rhythms in physiology and behavior. This clock research drives development of genomic and computational methods that we apply to other areas of biology. Finally, we recognize biological complexity and conduct this research at the network, rather than single gene, level.Selected Publications
Merrick David, Chapin Hannah, Baggs Julie E, Yu Zhiheng, Somlo Stefan, Sun Zhaoxia, Hogenesch John B, Caplan Michael J: The γ-Secretase Cleavage Product of Polycystin-1 Regulates TCF and CHOP-Mediated Transcriptional Activation through a p300-Dependent Mechanism. Developmental cell 22(1): 197-210, Jan 2012.Grant GR, Farkas MH, Pizarro A, Lahens N, Schug J, Brunk B, Stoeckert CJ, Hogenesch JB, Pierce EA: Comparative analysis of RNA-Seq alignment algorithms and the RNA-Seq Unified Mapper (RUM). Bioinformatics Jul 2011 (Epub ahead of print).
Xu K, DiAngelo JR, Hughes ME, Hogenesch JB, Sehgal A: The circadian clock interacts with metabolic physiology to influence reproductive fitness. Cell Metabolism 13(6): 639-654, 2011.
Huss JW, Lindenbaum P, Martone M, Roberts D, Pizarro A, Valafar F, Hogenesch JB, Su AI: The Gene Wiki: Community intelligence applied to human gene annotation. Nucleic Acids Research 38(Suppl 1): D633-D663, 2010.
Hughes ME, Peeler J, Hogenesch JB: Network dynamics to evaluate performance of an academic institution. Science Translational Medicine 2(53): 53ps49, 2010.
Andrews JL, Zhang X, McCarthy JJ, McDearmon EL, Hornberger TA, Russell B, Campbell KS, Arbogast S, Reid MB, Walker JR, Hogenesch JB, Takahashi JS, Esser KA: CLOCK and BMAL1 regulate MyoD and are necessary for maintenance of skeletal muscle phenotype and function. Proc Natl Acad Sci USA 107(44): 19090-19095, 2010.
Hughes ME, Hogenesch JB, Kornacker K: JTK_CYCLE: An efficient nonparametric algorithm for detecting rhythmic components in genome-scale data sets. J Biol Rhythms 25(5): 372-380, 2010.
Hughes ME, DiTacchio L, Hayes KR, Vollmers C, Pulivarthy S, Baggs JE, Panda S, Hogenesch JB: Harmonics of circadian gene transcription in mammals. PLoS Genetics 5(4): e1000442, 2009.
Baggs JE, Price TS, DiTacchio L, Panda S, FitzGerald GA, Hogenesch JB: Network features of the mammalian circadian clock. PLoS Biology 7(3): e52, 2009.
Warzecha CC, Sato TK, Nabet B, Hogenesch JB, Carstens RP: ESRP1 and ESRP2 are epithelial cell-type-specific regulators of FGFR2 splicing. Molecular Cell 33(5): 591-601, 2009.