John B. Hogenesch, Ph.D.
John B. Hogenesch, Ph.D.
Professor of Pharmacology
Department: Pharmacology
Graduate Group Affiliations
Contact information
Translational Research Center 10-124
3400 Civic Center Blvd., Bldg. 421
Philadelphia, PA 19104-5158
3400 Civic Center Blvd., Bldg. 421
Philadelphia, PA 19104-5158
Office: 484-842-4232
Email:
hogenesc@mail.med.upenn.edu
hogenesc@mail.med.upenn.edu
Links
Faculty Profile, Department of Pharmacology, Perelman School of Medicine at the University of Pennsylvania
Hogenesch Lab Homepage
Faculty Profile, Department of Pharmacology, Perelman School of Medicine at the University of Pennsylvania
Hogenesch Lab Homepage
Education:
B.A. (History)
University of Southern California, 1989.
B.S. (Biology)
University of Southern California, 1991.
Ph.D. (Neuroscience)
Northwestern University, 1999.
Permanent linkB.A. (History)
University of Southern California, 1989.
B.S. (Biology)
University of Southern California, 1991.
Ph.D. (Neuroscience)
Northwestern University, 1999.
Description of Research Expertise
Our laboratory studies the mammalian circadian clock using genomic and computational tools. We use these tools to discover new clock genes, learn how the clock keeps time, and how it coordinates rhythms in physiology and behavior. This clock research drives development of genomic and computational methods that we apply to other areas of biology. Finally, we recognize biological complexity and conduct this research at the network, rather than single gene, level.Selected Publications
Wozniak Michele A, Cheng Catherine Q, Shen Colette J, Gao Lin, Olarerin-George Anthony O, Won Kyoung-Jae, Hogenesch John B, Chen Christopher S: Adhesion Regulates MAP Kinase/Ternary Complex Factor Exchange to Control a Proliferative Transcriptional Switch. Current biology : CB Oct 2012.Miller Mayumi F, Cohen Ethan David, Baggs Julie E, Lu Min Min, Hogenesch John B, Morrisey Edward E: Wnt ligands signal in a cooperative manner to promote foregut organogenesis. Proceedings of the National Academy of Sciences of the United States of America Sep 2012.
Hughes Michael E, Hong Hee-Kyung, Chong Jason L, Indacochea Alejandra A, Lee Samuel S, Han Michael, Takahashi Joseph S, Hogenesch John B: Brain-specific rescue of clock reveals system-driven transcriptional rhythms in peripheral tissue. PLoS genetics 8(7): e1002835, Jul 2012.
Yusuf Dimas, Butland Stefanie L, Swanson Magdalena I, Bolotin Eugene, Ticoll Amy, Cheung Warren A, Zhang Xiao Yc, Dickman Christopher Td, Fulton Debra L, Lim Jonathan S, Schnabl Jake M, Ramos Oscar Hp, Vasseur-Cognet Mireille, de Leeuw Charles N, Simpson Elizabeth M, Ryffel Gerhart U, Lam Eric W-F, Kist Ralf, Wilson Miranda Sc, Marco-Ferreres Raquel, Brosens Jan J, Beccari Leonardo L, Bovolenta Paola, Benayoun Berenice A, Monteiro Lara J, Schwenen Helma Dc, Grontved Lars, Wederell Elizabeth, Mandrup Susanne, Veitia Reiner A, Chakravarthy Harini, Hoodless Pamela A, Mancarelli Michela, Torbett Bruce E, Banham Alison H, Reddy Sekhar P, Cullum Rebecca L, Liedtke Michaela, Tschan Mario P, Vaz Michelle, Rizzino Angie, Zannini Mariastella, Frietze Seth, Farnham Peggy J, Eijkelenboom Astrid, Brown Philip J, Laperriere David, Leprince Dominique, de Cristofaro Tiziana, Prince Kelly L, Putker Marrit, Del Peso Luis, Camenisch Gieri, Wenger Roland H, Mikula Michal, Rozendaal Marieke, Mader Sylvie, Ostrowski Jerzy, Rhodes Simon J, Van Rechem Capucine, Boulay Gaylor, Olechnowicz Sam Wz, Breslin Mary B, Lan Michael S, Nanan Kyster K, Wegner Michael, Hou Juan, Mullen Rachel D, Colvin Stephanie C, Noy Peter J, Webb Carol F, Witek Matthew E, Ferrell Scott, Daniel Juliet M, Park Jason, Waldman Scott A, Peet Daniel J, Taggart Michael, Jayaraman Padma-Sheela, Karrich Julien J, Blom Bianca, Vesuna Farhad, O'Geen Henriette, Sun Yunfu, Gronostajski Richard M, Woodcroft Mark W, Hough Margaret R, Chen Edwin, Europe-Finner Nicholas, Karolczak-Bayatti Magdalena, Bailey Jarrod, Hankinson Oliver, Raman Venu, Lebrun David P, Biswal Shyam, Harvey Christopher J, Debruyne Jason P, Hogenesch John B, Hevner Robert F, Heligon Christophe, Luo Xin M, Blank Marissa C, Millen Kathleen J, Sharlin David S, Forrest Douglas, Dahlman-Wright Karin, Zhao Chunyan, Mishima Yuriko, Sinha Satrajit, Chakrabarti Rumela, Portales-Casamar Elodie, Sladek Frances M, Bradley Philip H, Wasserman Wyeth W: The Transcription Factor Encyclopedia. Genome biology 13(3): R24, Mar 2012.
Merrick David, Chapin Hannah, Baggs Julie E, Yu Zhiheng, Somlo Stefan, Sun Zhaoxia, Hogenesch John B, Caplan Michael J: The γ-Secretase Cleavage Product of Polycystin-1 Regulates TCF and CHOP-Mediated Transcriptional Activation through a p300-Dependent Mechanism. Developmental cell 22(1): 197-210, Jan 2012.
Grant GR, Farkas MH, Pizarro A, Lahens N, Schug J, Brunk B, Stoeckert CJ, Hogenesch JB, Pierce EA: Comparative analysis of RNA-Seq alignment algorithms and the RNA-Seq Unified Mapper (RUM). Bioinformatics Jul 2011 (Epub ahead of print).
Xu K, DiAngelo JR, Hughes ME, Hogenesch JB, Sehgal A: The circadian clock interacts with metabolic physiology to influence reproductive fitness. Cell Metabolism 13(6): 639-654, 2011.
Huss JW, Lindenbaum P, Martone M, Roberts D, Pizarro A, Valafar F, Hogenesch JB, Su AI: The Gene Wiki: Community intelligence applied to human gene annotation. Nucleic Acids Research 38(Suppl 1): D633-D663, 2010.
Andrews JL, Zhang X, McCarthy JJ, McDearmon EL, Hornberger TA, Russell B, Campbell KS, Arbogast S, Reid MB, Walker JR, Hogenesch JB, Takahashi JS, Esser KA: CLOCK and BMAL1 regulate MyoD and are necessary for maintenance of skeletal muscle phenotype and function. Proc Natl Acad Sci USA 107(44): 19090-19095, 2010.
Hughes ME, Hogenesch JB, Kornacker K: JTK_CYCLE: An efficient nonparametric algorithm for detecting rhythmic components in genome-scale data sets. J Biol Rhythms 25(5): 372-380, 2010.