Struan Grant, PhD
Struan Grant, PhD
Assistant Professor of Pediatrics
Department: Pediatrics
Graduate Group Affiliations
Contact information
Center for Applied Genomics
Children’s Hospital of Philadelphia Research Institute
Rm 1216F, 3615 Civic Center Boulevard
Philadelphia, PA 19104
Children’s Hospital of Philadelphia Research Institute
Rm 1216F, 3615 Civic Center Boulevard
Philadelphia, PA 19104
Office: 267-426-2795
Fax: 267-426-0363
Fax: 267-426-0363
Links
Penn Medicine Profile
LinkedIn
CHOP Personal Profile
CHOP's Center for Applied Genomics Profile
Penn Medicine Profile
CHOP Personal Profile
CHOP's Center for Applied Genomics Profile
Education:
BSc (Genetics)
University of Aberdeen, UK, 1991.
PhD (Genetics)
University of Aberdeen, UK, 1995.
Permanent linkBSc (Genetics)
University of Aberdeen, UK, 1991.
PhD (Genetics)
University of Aberdeen, UK, 1995.
Description of Research Expertise
I have been conducting human genetics research for over 10 years. The highlights of my career are the discovery of the polymorphic Sp1 site in the COL1A1 gene and its association with osteoporosis, and the identification of variation in the TCF7L2 gene playing a role in more than 20 percent of type 2 diabetes cases. I have achieved these findings by working with key populations around the world that provide a unique insight into how to isolate human disease genes.My current work continues to primarily focus on metabolic disease, with a specific focus on pediatrics. Utilizing high-throughput genotyping technology, my goals include isolating genes involved in childhood obesity and pediatric bone strength determination. Both of these phenotypes are known to be strongly determined by genetic factors; however, the isolation of genes in these complex phenotypes in adults has been impeded by interaction with strong environmental factors. Distillation of the genetic component in these complex traits should be easier to determine in children, where the relatively short period of their lifetime limits the impact of environmental exposure. Given the global prevalence of obesity and osteoporosis, prevention of these disorders and their serious complications must be addressed in order to reduce individual morbidity and the economic burden on society.
Description of Clinical Expertise
NASelected Publications
J. Elia*, J.T. Glessner*, K. Wang, N. Takahashi, C.J. Shtir, D. Hadley, P.M.A. Sleiman, H. Zhang, C.E. Kim, R. Robison, G.J. Lyon, J.H. Flory, J.P. Bradfield, M. Imielinski, C. Hou, E.C. Frackelton, R.M. Chiavacci, T. Sakurai, C. Rabin, F.A. Middleton, K.A. Thomas, M. Garris, F. Mentch, C.M. Freitag, H.C. Steinhausen, A.A. Todorov, A. Reif, A. Rothenberger, B. Franke, E.O. Mick, H. Roeyers, J. Buitelaar, K.P. Lesch, T. Banaschewski, R.P. Ebstein, F. Mulas, R.D. Oades, J. Sergeant, E. Sonuga-Barke, T.J. Renner, M. Romanos, J. Romanos, A. Warnke, S. Walitza, J. Meyer, H. Pálmason, C. Seitz, S.K. Loo, S.L. Smalley, J. Biederman, L. Kent, P. Asherson, R.J.L. Anney, J.W. Gaynor, P. Shaw, M. Devoto, P.S. White, S.F.A. Grant, J.D. Buxbaum, J.L Rapoport, N.M. Williams, S.F. Nelson, S.V. Faraone and H. Hakonarson: Genome-wide copy number variation study associates metabotropic glutamate receptor gene networks with attention deficit hyperactivity disorder. Nature Genetics 44: 78-84, 2012 Notes: *equal contribution.S.F.A. Grant, J.T. Glessner, J.P. Bradfield, J. Zhao, J.E. Tirone, R.I. Berkowitz, H. Hakonarson and N. Sondheimer: Lack of relationship between mitochondrial heteroplasmy or variation and childhood obesity. International Journal of Obesity 36: 80-3, 2012.
J. Zhao*, J.P. Bradfield*, H. Zhang, P.M. Sleiman, C.E. Kim, J.T. Glessner, S. Deliard, K.A. Thomas, E.C. Frackelton, M. Li, R.M. Chiavacci, R.I. Berkowitz, H. Hakonarson and S.F.A. Grant: Role of adult BMI-associated loci identified in GWAS meta-analyses in the context of common childhood obesity in European Americans. Obesity 19: 2436-9, 2011 Notes: *equal contribution.
J.T. Glessner, J.P. Bradfield, K. Wang, N. Takahashi, H. Zhang, P.M. Sleiman, F.D. Mentch, C.E. Kim, C. Hou, K.A. Thomas, M.L. Garris, S. Deliard, E.C. Frackelton, F.G. Otieno, J. Zhao, R.M. Chiavacci, M. Li, J.D. Buxbaum, R.I. Berkowitz, H. Hakonarson* and S.F.A. Grant*: A Genome-wide Study Reveals Copy Number Variants Exclusive to Childhood Obesity Cases American Journal of Human Genetics 87: 661–666, 2010 Notes: *equal contribution.
J. Zhao*, J. Schug*, M. Li, K.H. Kaestner and S.F.A. Grant: Disease-associated loci are significantly over-represented among genes bound by TCF7L2 in vivo. Diabetologia 53: 2340-6, 2010 Notes: *equal contribution.
J. Zhao, J.P. Bradfield, H. Zhang, K. Annaiah, K. Wang, C.E. Kim, J.T. Glessner, E.C. Frackelton, F.G. Otieno, J. Doran, K.A. Thomas, M. Garris, C. Hou, R.M. Chiavacci, M. Li, R.I. Berkowitz, H. Hakonarson and S.F.A. Grant: Examination of all type 2 diabetes GWAS loci reveals HHEX-IDE as a locus influencing pediatric BMI. Diabetes 59: 751-755, 2010.
J. Zhao, M. Li, J.P. Bradfield, K. Wang, H. Zhang, P. Sleiman, C.E. Kim, K. Annaiah, W. Glaberson, J.T. Glessner, F.G. Otieno, K.A. Thomas, M. Garris, C. Hou, E.C. Frackelton, R.M. Chiavacci, R.I. Berkowitz, H. Hakonarson and S.F.A. Grant: Examination of type 2 diabetes loci implicates CDKAL1 as a birth weight gene. Diabetes 58: 2414-2418, 2009.
H. Hakonarson*, S.F.A. Grant*, J.P. Bradfield*, L. Marchand, C.E. Kim, J.T. Glessner, R. Grabs, T. Casalunovo, S.P. Taback, E.C. Frackelton, M.L. Lawson, L.J. Robinson, R. Skraban, Y. Lu, R.M. Chiavacci, C.A. Stanley, S.E. Kirsch, E.F. Rappaport, J.S. Orange, D.S. Monos, M. Devoto, H. Qu and C. Polychronakos: A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene. Nature 448(7153): 591-4, 2007 Notes: *equal contribution.
S.F.A. Grant, G. Thorleifsson, I. Reynisdottir, R. Benediktsson, A. Manolescu, J. Sainz, A. Helgason, H. Stefansson, V. Emilsson, A. Helgadottir, U. Styrkarsdottir, K.P. Magnusson, G. B. Walters, E. Palsdottir, T. Jonsdottir, T. Gudmundsdottir, A. Gylfason, J. Saemundsdottir, R.L. Wilensky, M.P. Reilly, D.J. Rader, Y. Bagger, C. Christiansen, V.Gudnason, G. Sigurdsson, U. Thorsteinsdottir, J.R. Gulcher, A. Kong and K. Stefansson : Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nature Genetics 38(3): 320-3, 2006.
S.F.A. Grant, D.M. Reid, G. Blake, R. Herd, I. Fogelman and S.H. Ralston: Reduced bone density and osteoporosis associated with a polymorphic Sp1 binding site in the collagen type I alpha 1 gene. Nature Genetics 14(2): 203-5, 1996.