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Ran Reshef, MD, MSc

Ran Reshef, MD, MSc

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Assistant Professor of Medicine at the Hospital of the University of Pennsylvania
Department: Medicine

Contact information
Hospital of the University of Pennsylvania
Division of Hematology & Oncology
Perelman Center for Advanced Medicine, 2nd floor West
3400 Civic Center Blvd.
Philadelphia, PA 19104
Office: 2153498940
Fax: 2156155887
Lab: 2155730642
B.Med.Sci. (Medical Science)
Tel-Aviv University, Israel, 1996.
M.D. (Medicine)
Sackler School of Medicine at Tel-Aviv University, Israel, 2003.
M.Sc. (Translational Research)
University of Pennsylvania, 2011.
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Description of Research Expertise

I conduct translational research in cellular therapy. My research focuses on finding new ways to modulate the graft-versus-host and graft-versus-tumor effects and improve the outcomes of stem-cell transplants in patients with blood cancers. Ongoing projects include determining the role of chemokine receptors in transplantation, and incorporating genomic methods to characterize the risk for graft-versus-host disease in order to develop targeted and personalized strategies to prevent it.

Selected Publications

Reshef R, Luger SM, Hexner EO, Loren AW, Frey NV, Nasta SD, Goldstein SC, Stadtmauer EA, Smith J, Bailey S, Mick R, Heitjan DF, Emerson SG, Hoxie JA, Vonderheide RH, Porter DL: Blockade of lymphocyte chemotaxis in visceral graft-versus-host disease. N Engl J Med 367(2): 135-45, July 2012.

Hardy NM, Fellowes V, Rose JJ, Hakim FT, Odom J, Pittaluga S, Steinberg SM, Blacklock-Schuver B, Avila DN, Memon S, Kurlander RJ, Khuu HM, Stetler-Stevenson M, Mena Gonzalez E, Dwyer AJ, Levine BL, June CH, Reshef R, Vonderheide RH, Gress RE, Fowler DH, Hakim FT, Bishop MR: Costimulated tumor-infiltrating lymphocytes are a feasible and safe alternative donor cell therapy for relapse after allogeneic stem cell transplantation. Blood 119(12): 2956-9, March 2012

Tizon R, Frey NV, Heitjan DF, Tan KS, Goldstein SG, Hexner EO, Loren AW, Luger SM, Vogl DT, Vozinak MJ, Fuchs B, Stadtmauer ES, Reshef R, Porter DL : High Dose Corticosteroids With or Without Etanercept for the Treatment of Idiopathic Pneumonia Syndrome after Allogeneic Stem Cell Transplantation. Bone Marrow Transplant 47(10): 1332-7, Oct 2012.

Kremer BE, Reshef R, Misleh J, Christie JD, Ahya VN, Blumenthal NP, Kotloff RM, Hadjiliadis D, Stadtmauer EA, Schuster SJ, Tsai DE : Post-Transplant Lymphoproliferative Disorder Following Lung Transplantation: A Review of 35 Cases. J Heart Lung Transplant 31(3): 296-304, March 2012.

Reshef R, Vardhanabhuti S, Luskin MR, Heitjan DF, Hadjiliadis D, Goral S, Krok KL, Goldberg LR, Porter DL, Stadtmauer EA, Tsai DE: Reduction of Immunosuppression as Initial Therapy for Post-Transplantation Lymphoproliferative Disorder. Am J Transplant 11(2): 336-347, 2011.

Reshef R, Luskin MR, Kamoun M, Vardhanabhuti S, Tomaszewski JE, Stadtmauer EA, Porter DL, Heitjan DF, Tsai DE: Association of HLA Polymorphisms with Post-Transplant Lymphoproliferative Disorder in Solid-Organ Transplant Recipients. Am J Transplant 11(4): 817-825, 2011.

Reshef R, Luger SM, Hexner EO, Loren AW, Frey NV, Goldstein SC, Nasta SD, Stadtmauer EA, Smith J, Mick R, Heitjan DF, Hoxie JA, Emerson SG, Vonderheide RH, Porter DL: Inhibition of Lymphocyte Trafficking Using a CCR5 Antagonist – Final Results of a Phase I/II Study. Blood 2011 Notes: Oral Presentation at the 53rd Annual American Society of Hematology Meeting, San Diego, CA, December 2011.

Reshef R, Mick R, Vassilev P, Smith J, Hexner EO, Loren AW, Frey NV, Goldstein SC, Stadtmauer EA, Luger SM, Porter DL : Whole Blood Donor Chimerism At Day 30 After Reduced Intensity Conditioned Allogeneic Stem-Cell Transplantation Predicts Disease Relapse, and Is Strongly Associated with Pretransplant Lymphodepletion. Blood 2011 Notes: Poster Presentation at the 53rd Annual American Society of Hematology Meeting, San Diego, CA, December 2011.

Rager A, Frey N, Goldstein SC, Reshef R, Hexner EO, Loren A, Luger SM, Perl A, Tsai D, Davis J, Vozniak M, Smith J, Stadtmauer EA, Porter DL : Inflammatory Cytokine Inhibition with Combination Daclizumab and Infliximab for Steroid Refractory Acute Graft-Versus-Host Disease. Bone Marrow Transplant 46(3): 430-435, 2011.

Beatty GL, Smith JS, Reshef R, Patel KP, Colligon TA, Vance BA, Frey NV, Johnson FB, Porter DL, Vonderheide RH: Functional unresponsiveness and replicative senescence of myeloid leukemia antigen- specific CD8+ T cells after allogeneic stem cell transplantation. Clin Cancer Res 15: 4944-53, 2009.

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Last updated: 03/27/2014
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