Gregory J. Nadolski, M.D.

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Assistant Professor of Radiology at the Hospital of the University of Pennsylvania
Department: Radiology

Contact information
Hospital of the University of Pennsylvania
Department of Radiology
1 Silverstein
3400 Spruce Street
Philadelphia, PA 19104
Office: 215.662.7892
Fax: 215.615.3545
Education:
B.S. (Biochemistry)
University of Wisconsin, Madison, WI , 2001.
M.D. (Medicine)
Indiana University School of Medicine, Indianapolis, IN , 2007.
MS (Translational Research)
University of Pennsylvania, 2017.
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Description of Clinical Expertise

My research and clinical interests include multimodality therapies for the treatment of hepatocellular carcinoma and liver dominant metastatic cancer.

I have initiated two clinical trials at the Hospital of the University of Pennsylvania for treating hepatocellular carcinoma. One involves combining transcatheter embolization with external beam radiation, and the other combines transcatheter embolization with an investigational oral chemotherapeutics.

Clinical Trials:
1. A Pilot Trial of Transarterial Chemoembolization With or Without Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma Patients Awaiting Liver Transplantation, Hospital of the University of Pennsylvania (UPCC16213)

2. Phase I-II Clinical Trial of the Safety of Hydroxychloroquine Combined with Transarterial Chemoembolization for Unresectable Hepatocellular Carcinoma, Hospital of the University of Pennsylvania (UPCC22213)

My other area of clinical and research interest is lymphatic injury, dysfunction, and malformations. Clinically, I perform thoracic duct embolization to treat chylothorax. I participate in research investigating novel lymphatic interventions to treat chylothorax, chylous ascites, refractory ascites and protein losing enteropathy.

Description of Research Expertise

In addition to my research investigating lymphatic interventions and multimodality cancer therapies, I also conduct research on vascular remodeling as it relates to hemodialysis access malfunction and peripheral arterial disease.

In this research, I am investigating a minimally invasive near infrared imaging system to evaluate hemodialysis access. The goal of this research is to detect changes in blood vessels that lead to stenosis before it becomes symptomatic. Detection of such changes at any early stage could improve development and monitor response of therapies to treat vascular disease.

Selected Publications

Meisinger QC, O'Brien S, Itkin M, Nadolski GJ.: Use of Sequential Pneumatic Compression Devices to Facilitate Propagation of Contrast during Intranodal Lymphangiography. JVIR 28(11): 1544-1547, November 2017.

DePietro DM, Kiefer RM, Redmond JW, Workman AD, Nadolski GJ, Gade TP, Trerotola SO, Hunt SJ: Increasing Medical Student Exposure to IR through Integration of IR into the Gross Anatomy Course. JVIR 28(10): 1455-1460, Oct 2017.

Habibollahi P, Hunt S, Gade T, Dagli MS, Mondschein JI, Sudheendra D, Stavropoulos SW, Soulen M, Gregory N.: The Impact of Bridging LRT on Survival in Patients Listed for Liver Transplantation. Cardiovascular and Interventional Radiology Aug 2017 Notes: epub ahead of print.

Kiefer RM, Hunt SJ, Pulido S, Pickup S, Furth EE, Soulen MC, Nadolski GJ, Gade TP.: Relative Initial Weight Is Associated with Improved Survival without Altering Tumor Latency in a Translational Rat Model of Diethylnitrosamine-Induced Hepatocellular Carcinoma and Transarterial Embolization. JVIR 28(7): 1043-1050, July 2017.

Gade TP, Tucker E, Nakazawa MS, Hunt SJ, Wong W, Krock B, Weber CN, Nadolski GJ, Clark TW, Soulen MC, Furth EE, Winkler JD, Amaravadi RK, Simon MC: Ischemia Induces Quiescence and Autophagy Dependence in Hepatocellular Carcinoma. Radiology 283(3): 702-710, June 2017.

Duncan C, Nadolski GJ, Gade T, Hunt S.: Understanding the Lung Abscess Microbiome: Outcomes of Percutaneous Lung Parenchymal Abscess Drainage with Microbiologic Correlation. Cardiovascular and Interventional Radiology 40(6): 902-906, June 2017.

Itkin M, Piccoli DA, Nadolski G, Rychik J, DeWitt A, Pinto E, Rome J, Dori Y.: Protein-Losing Enteropathy in Patients With Congenital Heart Disease. Journal of American College of Cardiology 69(20): 2929-2937, June 2017.

Hsu MC, Weber CN, Stavropoulos SW, Clark TW, Trerotola SO, Shlansky-Goldberg RD, Soulen MC, Nadolski GJ.: Passive expansion of sub-maximally dilated transjugular intrahepatic portosystemic shunts and assessment of clinical outcomes. World Journal of Hepatology 9(12): 603-612, April 2017.

Clark K, Chick JF, Reddy SN, Shin BJ, Nadolski GJ, Clark TW, Trerotola SO: Concurrent Central Venous Stent and Central Venous Access Device Placement Does Not Compromise Stent Patency or Catheter Function in Patients with Malignant Central Venous Obstruction. JVIR 28(4): 602-607, April 2017.

Chao C, Stavropoulos SW, Mondschein JI, Dagli M, Sudheendra D, Nadolski G, Soulen MC: Effect of Substituting 50% Isovue for Sterile Water as the Delivery Medium for SIR-Spheres: Improved Dose Delivery and Decreased Incidence of Stasis. Clinical Nuclear Medicine 42(3): 176-9, March 2017.

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Last updated: 11/03/2017
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