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George Scott Worthen, M.D.

George Scott Worthen, M.D.

faculty photo
Professor of Pediatrics
Department: Pediatrics

Contact information
Abramson Research Center, 416H
Children's Hospital of Philadelphia
3516 Civic Center Boulevard
Philadelphia, PA 19104-4318
Office: 215-590-5455
Education:
AB (History & Science)
Harvard College, 1973.
MD (Medicine)
Harvard Medical School, 1977.
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Selected Publications

Gray J, Oherle K, Wood J, Worthen GS, Ouyang, W, Alenghat T, Whitsett J, Deshmukh H: Commensal Bacteria direct the development of lung immunity in the neonate. Science Translational Medicine 2017 [in press]

Guo L, Feng K, Wang YC, Mei JJ, Ning RT, Zheng HW, Wang JJ, Worthen GS, Wang X, Song J, Li QH, Liu LD: Critical role of CXCL4 in the lung pathogenesis of influenza (H1N1) respiratory infection. Mucosal Immunol Jan 2017 [Epub ahead of print] Notes: doi: 10.1038/mi.2017.1.

Avgousti DC, Hermann C, Kulej K, Pancholi NJ, Sekulic N, Petrescu J, Molden RC, Blumenthal D, Paris AJ, Reyes ED, Ostapchuk P, Hearing P, Seeholzer SH, Worthen GS, Black BE, Garcia BA, Weitzman MD: A core viral protein binds host nucleosomes to sequester immune danger signals. Nature 535(7610): 173-177, Jul 2016.

Laudanski K, Qing M, Oszkiel H, Zawadka M, Lapko N, Nowak Z, Worthen GS: Ketamine affects in vitro differentiation of monocyte into immature dendritic cells. Anesthesiology 123(3): 628-641, Sept 2015.

Laudanski K, Qing M, Oszkiel H, Zawadka M, Lapko N, Nowak Z, Worthen GS: Ketamine affects in vitro differentiation of monocyte into immature dendritic cells. Anesthesiology 123(3): 628-641, Sep 2015.

Liu Y, O'Leary CE, Wang L-CS, Bhatti TR, Dai N, Kapoor V, Liu P, Mei JJ, Guo L, Oliver PM, Albelda SM, Worthen GS: CD11b+Ly6G+ cells inhibit tumor growth by suppressing IL-17 production at early stages of tumorigenesis. Oncoimmunology 5(1): e1061175, Jul 2015.

Qing DY, Conegliano D, Shashaty MG, Seo J, Reilly JP, Worthen GS, Huh D, Meyer NJ, Mangalmurti NS: Red blood cells induce necroptosis of lung endothelial cells and increase susceptibility to lung inflammation. Am J Respir Crit Care Med 190(11): 1243-1254, Dec 2014.

Gibbs J, Kearney L, Matthews L, Mei JJ, Bell T, Yang N, Saer B, Begley N, Poolman T, Pariollaud N, Farrow S, Demayo F, Hussell T, Worthen GS, Ray D, Loudon A: An epithelial circadian clock controls pulmonary inflammation and glucocorticoid action. Nat Med 20(8): 919-926, Aug 2014.

Jaeckle Santos LJ, Li C, Doulias PT, Ischiropoulos H, Worthen GS*, Simmons RA*: Neutralizing Th2 inflammation in neonatal islets prevents β-cell failure in adult IUGR rats. Diabetes. (*Co-last authors). Diabetes 63(5): 1672-1684, May 2014.

Deshmukh H, Liu Y, Menkiti O, Mei JJ, Dai N, O’Leary C, Oliver P, Kolls J, Weiser J, Worthen GS: The microbiota regulates neutrophil homeostasis and host resistance to E. coli K1 sepsis in neonatal mice. Nat Med 20(5): 524-530, May 2014.

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Last updated: 04/27/2017
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