Georges Worthen,
Georges Worthen
Professor of Pediatrics
Department: Pediatrics
Contact information
Abramson Research Center, 416H
Children's Hospital of Philadelphia
3516 Civic Center Boulevard
Philadelphia, PA 19104-4318
Children's Hospital of Philadelphia
3516 Civic Center Boulevard
Philadelphia, PA 19104-4318
Office: 215-590-5455
Education:
AB (History & Science)
Harvard College, 1973.
MD (Medicine)
Harvard Medical School, 1977.
Permanent linkAB (History & Science)
Harvard College, 1973.
MD (Medicine)
Harvard Medical School, 1977.
Selected Publications
Hyde DM, Downey GP, Tablin F, Rosengren S, Giclas PC, Henson PM, Worthen GS.: Age-dependent neutrophil and blood flow responsiveness in acute pulmonary inflammation in rabbits. Am J Physiol (Lung Cell and Mol Biol). 272: L471-L478, 1997.Knall C, Worthen GS, Johnson GL.: Interleukin-8 stimulated phosphatidylinositol 3-kinase activity regulates the migration of human neutrophils independent of ERK and p38 mitogen activated protein kinases. Proc Natl Acad Sci USA. 94: 3052-3057, 1997.
Nick JA, Avdi NJ, Young SK, Knall C, Gerwins P, Johnson GL, Worthen GS.: Common and distinct intracellular signaling pathways in human neutrophils utilized by platelet activating factor and FMLP. Clin Invest. 99: 975-986, 1997.
Avdi NA, Winston BW, Russell M, Young SK, Johnson GL, Worthen GS.: Activation of MEKK by FMLP in human neutrophils: Mapping pathways for MAP kinase activation. J Biol Chem. 271: 33598-33606, 1996.
Nick J, Avdi N, Johnson GL, Worthen GS.: Activation of a mammalian HOG1/p38 MAP kinase in human neutrophils by lipopolysaccharide. J Immunol. 156: 4867-4875, 1996.
Knall C, Young SK, Buhl AM, Worthen GS, Johnson GL.: Interleukin-8 regulation of the ras/raf/mitogen-activated protein kinase pathway in human neutrophils. J Biol Chem. 271: 2832-2838, 1996.
Parsons PE, Gillespie MMK, Moore EE, Moore FA, Worthen GS.: Neutrophil response to endotoxin in the adult respiratory distress syndrome: Role of CD 14. Am J Respir Cell Mol Biol. 13: 152-160, 1995.
Hellewell PG, Henson PM, Young SK, Worthen GS.: Paradoxic effect of ibuprofen on neutrophil accumulation in pulmonary and cutaneous inflammation. Am J Respir Crit Care Med. 151: 1218-1227, 1995.
Rosengren S, Henson PM, Worthen GS.: Migration-associated volume changes in neutrophils facilitate the migratory process. Am J Physiol Cell Physiol. 267: C1623-C1632, 1994.
Worthen GS, Henson PM, Rosengren SR, Downey GP, Hyde DM.: Neutrophils increase volume during migration in vivo and in vitro. Am J Resp Cell Mol Biol. 10: 1-7, 1994.