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George Scott Worthen, M.D.

George Scott Worthen, M.D.

faculty photo
Professor of Pediatrics
Department: Pediatrics

Contact information
Abramson Research Center, 416H
Children's Hospital of Philadelphia
3516 Civic Center Boulevard
Philadelphia, PA 19104-4318
Office: 215-590-5455
Education:
AB (History & Science)
Harvard College, 1973.
MD (Medicine)
Harvard Medical School, 1977.
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Selected Publications

Jaeckle Santos LJ, Li C, Doulias PT, Ischiropoulos H, Worthen GS*, Simmons RA*. *Co-last authors: Neutralizing Th2 inflammation in neonatal islets prevents β-cell failure in adult IUGR rats. Diabetes Jan 2014 [Epub ahead of print]

Deshmukh H, Liu Y, Menkiti O, Mei JJ, Dai, N. O’Leary C, Oliver P, Kolls J, Weiser J, Worthen GS: The microbiota regulates neutrophil homeostasis and host resistance to E. coli K1 sepsis in neonatal mice. Nat Med 2014 (in press).

Hudock KM, Liu Y, Mei J, Marino RC, Hale JE, Dai N, Worthen GS: Delayed resolution of lung inflammation in Il-1rn-/- mice reflects elevated IL-17A/granulocyte colony-stimulating factor expression. Am J Respir Cell Mol Biol 47(4): 436-444, Oct 2012.

Balamayooran G, Batra S, Cai S, Mei J, Worthen GS, Penn AL, Jeyaseelan S.: Role of CXCL5 in leukocyte recruitment to the lungs during secondhand smoke exposure. Am J Respir Cell Mol Biol 47(1): 104-111, Jul 2012.

Ramon H.E., Beal A., Liu Y., Worthen G.S., and P. M. Oliver: The E3 ubiquitin ligase adaptor Ndfip1 regulates Th17 differentiation by limiting the production of proinflammatory cytokines. J. Immunol 188(8): 4023-4031, Apr 2012.

Mei J, Liu Y, Dai N, Hoffmann C, Hudock KM, Zhang P, Guttentag SH, Kolls JK, Oliver PM, Bushman FD, Worthen GS: Cxcr2 and Cxcl5 regulate the IL-17/G-CSF axis and neutrophil homeostasis in mice. J Clin Invest 122(3): 974-986, Mar 2012.

Floros J, Londono D, Gordon D, Silveyra P, Diangelo SL, Viscardi RM, Worthen GS, Shenberger J, Wang G, Lin Z, Thomas NJ: IL-18R1 and IL-18RAP SNPs may be associated with bronchopulmonary dysplasia in African-American infants. Pediatr Res 71(1): 107-114, Jan 2012.

Fridlender ZG, Sun J, Mishalian I, Singhal S, Cheng G, Kapoor V, Horng W, Fridlender G, Bayuh R, Worthen GS, Albelda SM: Transcriptomic analysis comparing tumor-associated neutrophils with granulocytic myeloid-derived suppressor cells and normal neutrophils. PLoS One 7(2): e31524, 2012.

Liu Y, Mei J, Gonzales L, Yang G, Dai N, Wang P, Zhang P, Favara M, Malcolm KC, Guttentag S, Worthen GS: IL-17A and TNF- exert synergistic effects on expression of CXCL5 by alveolar type II cells in vivo and in vitro. J Immunol 186(5): 3197-3205, Mar 2011.

Fuentes R, Wang Y, Hirsch J, Wang C, Rauova L, Worthen GS, Kowalska MA, Poncz M: Infusion of mature megakaryocytes into mice yields functional platelets. J Clin Invest 120(11): 3917-3922, Nov 2010.

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Last updated: 03/27/2014
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