Rotonya M. Carr, MD

faculty photo
Assistant Professor of Medicine at the Hospital of the University of Pennsylvania
Department: Medicine

Contact information
421 Curie Boulevard
907 Biomedical Research Building II/III
Philadelphia, PA 19104
Office: 215-349-8222
Lab: 215-573-1874
Education:
B.A. (Biology Cum Laude)
Harvard University, 1996.
M.D.
Cornell University Medical College, 2001.
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Description of Clinical Expertise

Comprehensive management of fatty liver diseases

Description of Research Expertise

Translational and basic science research in liver metabolic diseases including non-alcoholic and alcoholic fatty liver disease, focusing on the pathologic role of lipids and lipid associated proteins.

Selected Publications

Williams B, Correnti J, Oranu A, Lin A, Scott V, Annoh M, Beck J, Furth E, Mitchell V, Senkal C, Obeid L, Carr RM: A novel role for ceramide synthase 6 in mouse and human alcoholic steatosis. FASEB Journal Sept. 2017 Notes: epub ahead of publication.

Carr, RM: In NAFLD, you are what you eat, not simply how much you eat. Cellular and Molecular Gastroenterology and Hepatology 4 (2): 301–302, June 2017.

Falk, G; Ginsberg, G; Katzka, D; Carr, RM; Hamilton, K; Wu, G: Presentation of the Julius M. Friedenwald Medal to Anil K. Rustgi. Gastroenterology June 2017.

Shubert, Rachel: New Study: Unsaturated Fat Associated with Fatty Liver Disease CMGH researchers report on the role of macronutrients in the development of metabolically unhealthy obesity. GastroPress June 2017 Notes: http://www.gastro.org/press_releases/new-study-unsaturated-fat-associated-with-fatty-liver-disease.

Carr RM, Dhir R, Mahadev K, Comerford M, Chalasani NP, Ahima RS: Perilipin Staining Distinguishes Between Steatosis and Nonalcoholic Steatohepatitis in Adults and Children. Clin Gastroenterol Hepatol 15(1): 145-47, Jan 2017.

Carr RM, *, Patel A *, Bownik H, Oranu A, Kerner C, Praestgaard A, Forde KA, K. Reddy KR, Lichtenstein GR *Co-first author: Intestinal Inflammation Does Not Predict Non-alcoholic fatty liver disease Severity in Inflammatory Bowel Disease Patients Digestive Diseases and Sciences 62(5): 1354-1361. 2017.

Amanke Oranu, MD, Victoria Mitchell, Victoria Scott, Bianca Williams, Jason Correnti, Ph.D., and Rotonya Carr, M.D. : Chronic alcohol consumption upregulates ceramide synthase 6 in hepatic lipid droplets and zone 3 hepatocytes of mice and humans AASLD 2017 2017 Notes: poster.

Alexis Ogdie, Sungat K. Grewal, Megan H. Noe, Daniel B. Shin, Junko Takeshita, Zelma C. Chiesa Fuxench, Rotonya M. Carr, and Joel M. Gelfand : Risk of incident liver disease in patients with psoriasis, psoriatic arthritis, and rheumatoid arthritis: a population-based study. Journal of Investigative Dermatology 2017.

Quezada, et al.: Diversity in GI Training: A Timely Goal. The New Gastroenterologist 2017.

Carr, Rotonya McCants and Lynch, John P: At the crossroads in the management of gastroesophageal junction carcinomas-where do we go from here? Gastrointestinal cancer research : GCR 2(5): 253-5, Sep 2008.

Wolden-Hanson T, Mitton DR, McCants RL, Yellon SM, Wilkinson CW, Matsumoto AM, Rasmussen DD: Daily melatonin administration to middle-aged male rats suppresses body weight, intraabdominal adiposity, and plasma leptin and insulin independent of food intake and total body fat. Endocrinology 141(2): 487-97, Feb 2000.

Carr RM, Mohrman L, Arelli V, Masters E: Update on Cause and Management of Catscratch Disease. Infections in Medicine 25(5): 242-250, 2008 Notes: http://infections.consultantlive.com/display/article/1145625/1404397.

Ahima R and Carr R: Alas! Ileal interposition surgery for diabetes prevention? Gastroenterology 138(7): 2437-46, April 2010.

Carr RM, Patel R, Rao V, Graham M, Crooke R, and Ahima R: Reduction of TIP47 improves hepatic steatosis and glucose homeostasis in mice. Am J Physiol Regul Integr Comp Physiol. 302(8): R996-1003, April 2012.

Carr RM, Patel R, Rao V, Graham M, Crooke R, and Ahima R: Reduction of TIP47 improves hepatic steatosis and glucose homeostasis in diet-induced obese mice. EASL 2011 Notes: Poster.

Rotonya Carr and James Lewis.: "This study by Mathurin et al. not only calls into question the longstanding practice of..." Evaluation of: [Mathurin P et al. Early liver transplantation for severe alcoholic hepatitis. N Engl J Med. 2011 Nov 10; 365(19):1790-800; doi: 10.1056/NEJMoa1105703]. Faculty of 1000, 19 Dec 2011. F1000.com/13408982 Faculty of 1000 December 2011.

Carr, Rotonya.: It’s lucky we found it. In E. Armstrong, M. Fischer, R Parsa-Parsi, and M. Wetzel (Eds.), The Health Care Dilemma: A Comparison of Health Care Systems in Three European Countries and the US (324-331). Singapore: World Scientific Publishing Co. The Health Care Dilemma: A Comparison of Health Care Systems in Three European Countries and the US (324-331). Singapore: World Scientific Publishing Co. 2011.

Carr RM, Kalyankar M, Dhir R,Comerford M, Chalasani N, and Ahima RS: Differential expression of PLIN1 and PLIN2 in fatty liver diseases in adults and children IDOM 2015 Notes: Poster.

Carr RM, Dhir R, Yin X, Agarwal B, Ahima RS: Temporal effects of ethanol consumption on energy homeostasis, hepatic steatosis and insulin sensitivity in mice Alcohol Clin Exp Res 37(7): 1091-9, Jul 2013 Notes: 2013 Feb 7. doi: 10.1111/acer.12075.

Carr RM, Patel A, Kerner C, Tierney A, Forde K, and Lichtenstein G.: Metabolic syndrome and IBD severity may increase risk of NAFLD. Digestive Disease Week 2013 Notes: Poster.

McConnell R, Carr RM.: Headache with Hematochezia: A Case of Sumatriptan-Induced Ischemic Colitis Digestive Disease Week 2013 Notes: Poster.

Carr RM, Patel A, Kerner C, Tierney A, Forde K, and Lichtenstein G.: Metabolic syndrome, but not IBD severity, increases risk of NAFLD severity in patients with dual diagnosis of IBD and NAFLD. American Association for the Study of Liver Diseases (AASLD) 2013 Notes: Poster.

Rotonya Carr: Understanding the pathogenesis of insulin resistance in non-alcoholic and alcoholic liver diseases. JSM Gastroenterology and Hepatology 1: 1002, 2013 Notes: http://www.jscimedcentral.com/Gastroenterology/Articles/gastroenterology-1-1002.pdf.

Carr RM, Peralta G, Yin X, Ahima RS: Absence of Perilipin 2 Prevents Hepatic Steatosis, Glucose Intolerance and Ceramide Accumulation in Alcohol-fed Mice. PLoS One 9(5): e97118, May 2014 Notes: Corresponding author.

Roland Li, Ann Tierney, and Rotonya Carr: The Impact of Peri-Discharge Interventions on 30-day Readmission and 90-day Mortality Rates for Patients Admitted with Hepatic Encephalopathy. ACG National Meeting 2014 2014 Notes: Poster.

Carr, RM and Reid, Andrea.: FXR agonists as Therapeutic Agents for Non-alcoholic Fatty Liver Disease. Current Atherosclerosis Reports 17(4), Apr 2015 Notes: Invited review.

Carr, RM, Correnti, J: Insulin resistance in clinical and experimental alcoholic liver disease. Ann N Y Acad Sci 1353: 1-20, Sep 2015.

Correnti, J; Williams, B; Gottshall, L; and Carr, RM.: Oleate, palmitate and C2 ceramide differentially impact lipid oxidation and trafficking in alcohol-treated human hepatoma cells. Gordon conference 2015 Notes: Poster.

Carr, RM and Ahima RS.: Pathogenesis of Lipid Droplet Proteins in Liver Diseases. Experimental Cell Research 340(2):187-92., Jan 2016 Notes: Invited review. Corresponding author.

Kupfer SS, Carr RM, Carethers J: Reducing colorectal cancer risk among African-Americans. Gastroenterology 149(6): 1302-4, Nov 2015.

Williams B, Correnti J, Carr RM. : Ceramide Synthase May Regulate Hepatic Perilipin 2 and Lipid Metabolism in Experimental Alcoholic Steatosis. AASLD Conference 2015 Notes: Poster.

Carr, RM; Oranu, A; Khungar, V.: Non-alcoholic fatty liver disease: Pathogenesis and Current Management. Clinics in Gastroenterology 45(4), Dec. 2016 Notes: Invited review.

Williams,B; Correnti,J, Oranu,A; Lin,A; Beck, J. and Carr, RM: Ceramide Synthase May Regulate Hepatic Perilipin 2 and Lipid Metabolism in Experimental Alcoholic Steatosis. FASEB Lipid Droplets: Dynamic Organelles in Metabolism and Beyond Conference 2016 Notes: Poster.

Oranu,A; Lin,A.; Williams, B; Correnti,J; Beck,J; and Carr,RM : Absence of Perilipin 2 prevents the increase of long-chain ceramides in the lipid droplet fractions of alcohol-fed mice Hepatology 64(S1), October 2016 Notes: Poster.

Oranu, A; Williams, B; Correnti, J; Scott, V; Mitchell, V.; and Carr, RM: Absence of Perilipin 2 prevents the increase of long-chain ceramides in the lipid droplet fractions of alcohol-fed mice. Gordon Research Conference 2017 Notes: Oral.

Roland Li, MD; Marina Serper, MD, MS; Vandana Khungar, MD, MSc; Amy Praestgaard, MS and Rotonya M. Carr, MD : Impact of race/ethnicity and primary admission diagnosis on readmission and mortality rates among patients hospitalized with hepatic encephalopathy AASLD 2017 2017 Notes: poster.

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Last updated: 02/15/2018
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