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James K Mangan, MD, Ph.D.

James K Mangan, MD, Ph.D.

faculty photo
Assistant Professor of Clinical Medicine
Department: Medicine

Contact information
Perelman Center for Advanced Medicine
34th Street and Civic Center Blvd
2nd Floor, West Pavilion
Philadelphia, PA 19104
BS (Biology-Molecular, Cellular and Development)
Haverford College, 1998.
Ph.D. (Molecular Biology and Genetics)
Temple University, 2005.
Temple University, 2005.
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Perelman School of Medicine > Faculty > Search

Selected Publications

Hexner E, Luger SM, MANGAN JK, Frey NV, Jeschke GR, Frank D, Reshef R, Loren AW, Goldstein SC, Rosenbach M, Nowaczyk C, Schuster M, Stadtmauer EA, Levine BL, June CH, Emerson SG, and Porter DL : A phase 1 dose escalation study of infusion of ex vivo CD3/CD28 costimulated umbilical cord blood-derived T cells in adults undergoing transplantation for advanced hematologic malignancies, abstract 3032. American Society of Hematology Annual Meeting 2011 Notes: Poster Presentation.

Mangan JK and Luger SM : Salvage therapy for relapsed or refractory acute myeloid leukemia. Therapeutic Advances in Hematology 2: 73-82, 2011.

Mangan JK and Speck NA: Runx1 mutations in clonal myeloid disorders: From conventional cytogenetics to next generation sequencing, a story 40 years in the making. Critical Reviews in Oncogenesis 16: 77-91, 2011.

Perl AE, Jeschke GR, Smith CC, MANGAN JK, Luger SM, and Carroll M : Phospho-specific flow cytometry of fixed whole blood demonstrates in vivo FLT3 inhibition in circulating leukemic blasts during AC220 therapy and accurately detects the development of therapeutic resistance, abstract 3502. American Society of Hematology Annual Meeting 2011 Notes: Poster Presentation.

Mangan JK and Russell JE : Profound neutropenia resulting from metyrapone-induced adrenal crisis. Amer J Hemat 84: 773, 2009.

Mangan JK, Tantravahi RV, Rane SG, and Reddy EP : Granulocyte colony- stimulating factor-induced upregulation of Jak3 transcription during myeloid differentiation is mediated by the cooperative action of Sp1 and Stat3. Oncogene Page: 2489-2499, 2006.

Mangan JK and Reddy EP : Activation of the Jak3 pathway and myeloid differentiation Leukemia and Lymphoma 46: 21-27, 2005.

Mangan JK, Rane SG, Kang AD, Amanullah A, Wong BC, and Reddy EP : Mechanisms associated with IL-6-induced upregulation of Jak3 and its role in monocytic differentiation. Blood 103: 4093-4101, 2004.

Rane SG, Mangan JK, Amanullah A, Wong BC, Vora RK, Liebermann DA, Hoffman B, Grana X, and Reddy EP : Activation of the Jak3 pathway is associated with granulocytic differentiation of myeloid precursor cells. Blood 100: 2753-2762, 2002.

Cai X, Gaudett JJ, Mangan JK, Chen MJ, De Obaldia ME, Oo Z, Ernest P, and Speck NA: Runx1 loss minimally impacts long-term hematopoietic stem cells. PloS ONE 6: e28430, Dec 2001 Notes: Epub.

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Last updated: 04/04/2012
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