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James K Mangan, MD, Ph.D.

James K Mangan, MD, Ph.D.

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Assistant Professor of Clinical Medicine
Department: Medicine

Contact information
Perelman Center for Advanced Medicine
34th Street and Civic Center Blvd
2nd Floor, West Pavilion
Philadelphia, PA 19104
Education:
BS (Biology-Molecular, Cellular and Development)
Haverford College, 1998.
MD
Temple University, 2005.
Ph.D. (Molecular Biology and Genetics)
Temple University, 2005.
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Selected Publications

Reshef R, Hexner EO, Loren AW, Frey NV, Stadtmauer EA, Luger SM, Mangan JK, Gill SI, Vassilev P, Smith J, Van Deerlin VM, Mick R, and Porter DL : Early donor chimerism levels predict relapse and survival after allogeneic stem cell transplantation with reduced intensity conditioning. Biol Blood Marrow Transplant 20(11), 2014.

Bagley SJ, Sehgal AR, Frey NV, Gill S, Hexner E, Loren AW, Mangan JK, Porter DL, Reshef R, Stadtmauer EA, and Luger S. : Acute cholecystitis occurs more commonly than expected following allogeneic hematopoietic stem cell transplantation and is ineffectively diagnosed using abdominal ultrasound. American Society of Hematology Annual Meeting, 2013(721), 2013.

Perl AE, Jeschke GR, Smith CC, Mangan JK, Luger SM, and Carroll M.: Single-cell pharmacodynamic monitoring of ribosomal phosphorylation during AC220 therapy demonstrates in vivo FLT3 inhibition in circulating leukemic blasts and accurately detects the development of AC220 resistance. American Society of Hematology Annual Meeting(2453), 2013.

Diab A, Zickl L, Abdel-Wahab O, Jhanwar S, Gulam MA, Panageas KS, Patel JP, Jurcic J, Maslak P, Paietta E, Mangan JK, Carroll M, Fernandez HF, Teruya-Feldstein J,Luger SM, Douer D, Litzow MR, Lazarus HM, Rowe JM, Levine RL, and Tallman MS : Acute myeloid leukemia with translocation t(8;16)presents with features that mimic acute promyelocytic leukemia and is associated with poor prognosis. Leukemia Research 37, 2013.

Mangan JK and Luger SL: A paraneoplastic syndrome characterized by extremity swelling with associated inflammatory infiltrate heralds aggressive transformation of myelodysplastic syndromes/myeloproliferative neoplasms to acute myeloid leukemia: a case series. Case Reports in Hematology(epub), June 2012.

Kasner M, Weiss M, Flomenberg N, Luger SM, Loren AW, Carabasi M, Wagner JL, Mangan JK et al. : Sirolimus plus MEC chemotherapy has significant activity in high risk AML patients especially those who exhibit in vivo inhibition of the mTOR pathway. American Society of Hematology Annual Meeting(143), 2012.

Frey NV, Hexner EO, Porter DL, Mangan JK, Loren AW, Hatem J, Bagg A, Perl AE, Tsai DE, DiNardo CD, Heitjian D, Luger SM, and Carroll M.: A phase I clinical trial using eltrombopag in patients with acute myelogenous leukemia. American Society of Hematology Annual Meeting(3576), 2012.

Cai X, Gaudet JJ, Mangan JK, Chen MJ, De Obaldia ME, Oo Z, Ernest P, and Speck NA: Runx1 loss minimally impacts long-term hematopoietic stem cells. PloS ONE 6: e28430, Dec 2011 Notes: Epub.

Hexner E, Luger SM, Mangan JK, Frey NV, Jeschke GR, Frank D, Reshef R, Loren AW, Goldstein SC, Rosenbach M, Nowaczyk C, Schuster M, Stadtmauer EA, Levine BL, June CH, Emerson SG, and Porter DL : A phase 1 dose escalation study of infusion of ex vivo CD3/CD28 costimulated umbilical cord blood-derived T cells in adults undergoing transplantation for advanced hematologic malignancies, abstract 3032. American Society of Hematology Annual Meeting 2011 Notes: Poster Presentation.

Perl AE, Jeschke GR, Smith CC, Mangan JK, Luger SM, and Carroll M : Phospho-specific flow cytometry of fixed whole blood demonstrates in vivo FLT3 inhibition in circulating leukemic blasts during AC220 therapy and accurately detects the development of therapeutic resistance, abstract 3502. American Society of Hematology Annual Meeting 2011 Notes: Poster Presentation.

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Last updated: 10/20/2014
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