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James K Mangan, MD, Ph.D.

James K Mangan, MD, Ph.D.

faculty photo
Assistant Professor of Clinical Medicine
Department: Medicine

Contact information
Perelman Center for Advanced Medicine
34th Street and Civic Center Blvd
2nd Floor, West Pavilion
Philadelphia, PA 19104
Education:
BS (Biology-Molecular, Cellular and Development)
Haverford College, 1998.
MD
Temple University, 2005.
Ph.D. (Molecular Biology and Genetics)
Temple University, 2005.
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Selected Publications

Reshef R, Huffman AP, Gao A, Luskin MR, Frey NV, Gill SI, Hexner EO, Kambayashi T, Loren AW, Luger SM, Mangan JK, Nasta SD, Richman LP, Sell M, Stadtmauer EA, Vonderheide RH, Mick R, Porter DL: High graft CD8 cell dose predicts improved survival and enables better donor selection in allogeneic stem-cell transplantation with reduced-intensity conditioning. J Clin Oncol epub ahead of print, June 2015.

Bagley SJ, Sehgal AR, Gill S, Frey NV, Hexner EO, Loren AW, Mangan JK, Porter DL, Stadtmauer EA, Reshef R, Luger SM.: Acute cholecystitis is a common complication after allogeneic stem cell transplantation and is associated with the use of total parenteral nutrition. Biol Blood Marrow Transplant 21(4): 768-771, April 2015.

Orlowski, RJ, Mangan JK, Luger SM. : Approach to patients with primary refractory acute myeloid leukemia. Curr Opin Hematol 22(2): 97-107, March 2015.

Reshef R, Huffman AP, Gao A, Sell M, Luskin M, Luger S, Loren A, Hexner EO, Nasta SD, Frey NV, Gill S, Mangan J, Richman LP, Kambayashi T, Stadtmauer EA, Vonderheide RH, Mick R, Porter DL: A survival benefit for reduced intensity allogeneic transplants from young unrelated donors compared to older sibling donors depends on the graft CD8 T-Cell content. American Society of Bone Marrow Transplantation/Center for International Bone Marrow Transplantation Research Tandem Meetings 2015.

Reshef R, Hexner EO, Loren AW, Frey NV, Stadtmauer EA, Luger SM, Mangan JK, Gill SI, Vassilev P, Smith J, Van Deerlin VM, Mick R, and Porter DL : Early donor chimerism levels predict relapse and survival after allogeneic stem cell transplantation with reduced intensity conditioning. Biol Blood Marrow Transplant 20(11), 2014.

Mesa R, Miller CB, Thyne M, Mangan J, Goldberger S, Fazal S, Ma X, Wilson W, Dubinski DG, Boyle J, and Mascarenhas JO. : Impact of myeloproliferative noeplasms (MPNs) on patients' overall health and productivity: results from the MPN LANDMARK SURVEY in the United States. American Society of Hematology Annual Meeting(3183), 2014.

Mesa R, Miller CB, Thyne M, Mangan J, Goldberger S, Fazal S, Ma X, Wilson W, Dubinski DG, Boyle J, and Mascarenhas JO. : Gaps in perception between patients and physicians regarding symptomatology and treatment attitudes for myeloprolifertive neoplasms: MPN LANDMARK SURVEY. American Society of Hematology Annual Meeting(4827), 2014.

Zebrowski A, Hanlon A, Mangan J, Pinto-Martin J, Luger SM, Loren AW, Hexner EO, Reshef R, Gill SI, Smith J, Stadtmauer EA, Porter D, and Frey NV. : Clofarabine busulfan conditioning improves outcomes in patients with active acute myelogenous leukemia undergoing allogeneic stem cell transplant. American Society of Hematology Annual Meeting(1239), 2014.

Frey NV, Luger S, Mangan J, Zebrowski A, Loren AW, Minderman H, Baird J, Porter DL, Hexner EO, Kumar AJ, Luskin MR, Perl AE, and Carroll M: A Phase I study using single agent birinapant in patients with relapsed myelodysplastic syndrome and acute myelogenous leukemia. American Society of Hematology Annual Meeting(3758), 2014.

Reshef R, Huffman AP, Gao A, Sell M, Luskin MR, Luger SM, Loren AW, Hexner EO, Nasta SD, Frey NV, Gill SI, Mangan J, Richman LP, Kambayashi T, Stadtmauer EA, Vonderheide RH, and Porter DL: CD8 cell dose in peripheral blood stem-cell grafts correlates with relapse and survival after reduced intensity conditioning allogeneic stem cell transplantation. American Society of Hematology Annual Meeting(1260), 2014.

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Last updated: 07/03/2015
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