Ramachandran Murali, Ph.D.
Ramachandran Murali, Ph.D.
Adjunct Associate Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine
Contact information
243 John Morgan Bldg.3620 Hamilton Walk
Philadelphia, PA 19104
Philadelphia, PA 19104
Office: 215-573-9256
Fax: 215-898-2401
Fax: 215-898-2401
Email:
murali@med.med.upenn.edu
murali@med.med.upenn.edu
Education:
B.Sc. (Physics)
University of Madras, India, 1978.
M.Sc. (Physics)
University of Madras,India, 1980.
Ph.D. (Biophysics)
University of Madras, India, 1986.
Permanent linkB.Sc. (Physics)
University of Madras, India, 1978.
M.Sc. (Physics)
University of Madras,India, 1980.
Ph.D. (Biophysics)
University of Madras, India, 1986.
Description of Research Expertise
Structural Biology, Cancer Biology and ImmunologyDescription of Other Expertise
Drug DesignSelected Publications
Guillemard, V., Nedev, HN., Berezov, A., Murali, R. and Saragovi, U.: HER2-mediated internalization of a targeted prodrug cytotoxic conjugate is dependent on the valaency of the targeting ligand. DNA Cell Biol. 24(6): in press, Jun 2005.Murali, R., Cheng,X., Berezov, A., Du, X., Schon, A., Freire, E., Xu, X., Chen, Y.H. and Greee, M.I.: Disabling TNF receptor signaling by induced conformational perturbation of tryptophan-107. Proc Natl Acad Sci U S A 102: 10970-10975, July 2005.
Cheng, X., Kinosaki, M., Takami, M., Choi, Y., Zhang, H. & Murali, R. : Disabling of receptor activator of nuclear factor-kappaB (RANK) receptor complex by novel osteoprotegerin-like peptidomimetics restores bone loss in vivo. J. Biol. Chem 279: 8269-8277, 2004.
Hasegawa A, Cheng X, Kajino K, Berezov A, Murata K, Nakayama T, Yagita H, Murali R*, Greene MI. : Fas-disabling small exocyclic peptide mimetics limit apoptosis by an unexpected mechanism. Proc Natl Acad Sci U S A 101: 6599-6604, 2004.
Berezov, A., Greene, M. I. & Murali, R. : Structure-Based Approaches to Inhibition of erbB Receptors with Peptide Mimetics Immunol Res 27: 303-308, 2003.
Murali, R., Liu, Q., Cheng, X., Berezov, A., Richter, M., Furuchi, K., Greene, M. I. & Zhang, H. : Antibody like peptidomimetics as large scale immunodetection probes Cell Mol Biol 49: 209-216, 2003.
Kim, N., Ussin, L., Cheng, X., Murali, R. & Sullivan, K. E. : TNFalpha Inhibition in MRL/lpr Mice Ameliorates Pulmonary but not Renal Disease J Autoimmun 19: 215-222. 2002.
Horie, T., Shen, Y., Kajino, K., Gaubin, M., Bonomi, G., Mani, J , Berezov, A., Piatier-Tonneau, D., Guardiola, J., Hillard, B., Rostami, A., Greene, M. I., Murali, R. : Study of disabling T-cell activation and inhibiting T-cell mediated immunopathology reveals a possible inverse agonist activity of CD4 peptidomimetics. Exp. Mol. Pathology 73: 93-97, 2002.
Berezov, A., Chen, J.., Liu, Q., Zhang, H., Greene, M.I. Murali, R : Disabling Receptor Ensembles with Rationally Designed Interface Peptidomimetics. J. Biol. Chem. 277: 28330-28339, 2002.
Murali, R., Kajino, K., Hasegawa, A., Berezov, A. & Takasaki, W. : Design and Development of small molecule inhibitor of TNF alpha, eds. Ciliberto, G. & Savino, R. (eds.). Marcel Dekker, Inc., New York, NY,(Chapter 5), 133-161, 2001.