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Ramachandran Murali, Ph.D.

Ramachandran Murali, Ph.D.

faculty photo
Department: Pathology and Laboratory Medicine

Contact information
243 John Morgan Bldg.3620 Hamilton Walk
Philadelphia, PA 19104
Office: 215-573-9256
Fax: 215-898-2401
B.Sc. (Physics)
University of Madras, India, 1978.
M.Sc. (Physics)
University of Madras,India, 1980.
Ph.D. (Biophysics)
University of Madras, India, 1986.
Permanent link
Perelman School of Medicine > Faculty > Search

Description of Research Expertise

Structural Biology, Cancer Biology and Immunology

Description of Other Expertise

Drug Design

Selected Publications

Guillemard, V., Nedev, HN., Berezov, A., Murali, R. and Saragovi, U.: HER2-mediated internalization of a targeted prodrug cytotoxic conjugate is dependent on the valaency of the targeting ligand. DNA Cell Biol. 24(6): in press, Jun 2005.

Murali, R., Cheng,X., Berezov, A., Du, X., Schon, A., Freire, E., Xu, X., Chen, Y.H. and Greee, M.I.: Disabling TNF receptor signaling by induced conformational perturbation of tryptophan-107. Proc Natl Acad Sci U S A 102: 10970-10975, July 2005.

Cheng, X., Kinosaki, M., Takami, M., Choi, Y., Zhang, H. & Murali, R. : Disabling of receptor activator of nuclear factor-kappaB (RANK) receptor complex by novel osteoprotegerin-like peptidomimetics restores bone loss in vivo. J. Biol. Chem 279: 8269-8277, 2004.

Hasegawa A, Cheng X, Kajino K, Berezov A, Murata K, Nakayama T, Yagita H, Murali R*, Greene MI. : Fas-disabling small exocyclic peptide mimetics limit apoptosis by an unexpected mechanism. Proc Natl Acad Sci U S A 101: 6599-6604, 2004.

Berezov, A., Greene, M. I. & Murali, R. : Structure-Based Approaches to Inhibition of erbB Receptors with Peptide Mimetics Immunol Res 27: 303-308, 2003.

Murali, R., Liu, Q., Cheng, X., Berezov, A., Richter, M., Furuchi, K., Greene, M. I. & Zhang, H. : Antibody like peptidomimetics as large scale immunodetection probes Cell Mol Biol 49: 209-216, 2003.

Kim, N., Ussin, L., Cheng, X., Murali, R. & Sullivan, K. E. : TNFalpha Inhibition in MRL/lpr Mice Ameliorates Pulmonary but not Renal Disease J Autoimmun 19: 215-222. 2002.

Horie, T., Shen, Y., Kajino, K., Gaubin, M., Bonomi, G., Mani, J , Berezov, A., Piatier-Tonneau, D., Guardiola, J., Hillard, B., Rostami, A., Greene, M. I., Murali, R. : Study of disabling T-cell activation and inhibiting T-cell mediated immunopathology reveals a possible inverse agonist activity of CD4 peptidomimetics. Exp. Mol. Pathology 73: 93-97, 2002.

Berezov, A., Chen, J.., Liu, Q., Zhang, H., Greene, M.I. Murali, R : Disabling Receptor Ensembles with Rationally Designed Interface Peptidomimetics. J. Biol. Chem. 277: 28330-28339, 2002.

Murali, R., Kajino, K., Hasegawa, A., Berezov, A. & Takasaki, W. : Design and Development of small molecule inhibitor of TNF alpha, eds. Ciliberto, G. & Savino, R. (eds.). Marcel Dekker, Inc., New York, NY,(Chapter 5), 133-161, 2001.

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Last updated: 11/21/2013
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