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J. Eduardo Rame, M.D., M.Phil

J. Eduardo Rame, M.D., M.Phil

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Assistant Professor of Medicine at the Hospital of the University of Pennsylvania
Department: Medicine

Contact information
Penn Medicine
Heart Failure, Mechanical Assist and Cardiac Transplant Center
Hospital of the University of Pennsylvania
2 East, Perelman Center for Advanced Medicine
3400 Civic Center Boulevard
Philadelphia, PA 19104
Office: 215-615-7949
Fax: 215-349-5603
Education:
B.S., M.S. (Molecular Biophysics and Biochemistry)
Yale College, 1990.
M.Phil (Statistics/Health Services Research)
Oxford University , 1996.
M.D. (Medicine)
Harvard Medical School , 1997.
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Description of Clinical Expertise

I am cardiovascular specialist in the area of cardiomyopathy, chronic heart faiure, and pulmonary hypertension, focusing my clinical efforts in the more advanced stage of right and left heart failure syndromes. I am the current medical director of the mechanical circulatory support device program at the University of Pennsylvania and the clinical expertise that I bring to this program specifically involves phenotyping right ventricular function and right ventricular reserve in chronic heart failure. As a practitioner in various disease states causing pulmonary hypertension, I also have developed an expertise in characterizing right ventricular dysfunction due to RV-PA uncoupling in high pulmonary afterload syndrome (PAH).

In the area of advanced heart failure and Left ventricular assist device support (LVAD), I also bring a specialized program of myocardial recovery by optimizing the degree of mechanical unloading with a LVAD and maximizing the medical therapy that can be tolerated in an effort to drive the process of reverse myocardial remodeling to improve heart function. This is a highly specialized area in the field of advanced heart failure with only a handful of centers world-wide providing this therapeutic approach to their patients.

Description of Research Expertise

My role as an advanced heart failure clinician-scientist and director of the mechanical assist device program at Penn is to provide expertise in the area of myocardial failure in the more advanced stage of this syndrome. More recently I have been working on the emerging interface of metabolism and heart failure. The current focus of my research is the investigation of myocardial and systemic metabolism in the syndrome of chronic heart failure. Specifically, myocardial and systemic insulin resistance is being increasingly targeted as a mechanism of disease progression in chronic heart failure and the objectives as a translational researcher within my group have been to: 1. Understand the role of lipid and adipocytokine biology (leptin, adiponectin, resistin) in the emerging metabolic phenotype of heart failure; 2. Identify specific targets for improving myocardial energetics and whole-body metabolism in cardiomyopathic failure; and 3. Test the safety and efficacy through carefully designed pilot studies of “reversing” specific metabolic pathways which have been dysregulated in human heart failure. My collaborative network for this research currently includes the laboratories of Dr. Tim McGraw, Dr. Richard Shannon, Dr. Ken Margulies and Dr. Tom Cappola within my own group at Penn as well as the laboratory of Dr. Christian Schulze and Professor Ira Goldberg at Columbia University.

Selected Publications

J. Eduardo Rame: Is Chronic Heart Failure a Reversible Metabolic Syndrome. Heart And Metabolism. Mario Marzilli (eds.). Servier, 61, November 2013.

Starling RC, Moazami N, Silvestry SC, Ewald G, Rogers JG, Milano CA, Rame JE, Acker MA, Blackstone EH, Ehrlinger J, Thuita L, Mountis MM, Soltesz EG, Lytle BW, Smedira NG: Unexpected Abrupt Increase in Left Ventricular Assist Device Thrombosis. The New England Journal of Medicine 370(1): 1-8, Nov 2013.

Neeland IJ, Gupta S, Ayers CR, Turer AT, Rame JE, Das SR, Berry JD, Khera A, McGuire DK, Vega GL, Grundy SM, de Lemos JA, Drazner MH: Relation of regional fat distribution to left ventricular structure and function. Circ Cardiovasc Imaging 6(5): 800-7, Sep 2013.

Ramjee V, Shreenivas S, Rame JE, Kirkpatrick JN, Jagasia D: Complete Spontaneous Left Heart and Aortic Thromboses on Extracorporeal Membrane Oxygenation Support. Echocardiography (Mount Kisco, N.Y.). (eds.). 30(10): E342–E343, Nov 2013 Notes: Epub 2013 Jul 27.

Rame JE, Ramjee V, Plappert T, St. John Sutton M, Kirkpatrick JM: Longitudinal Study of Right Ventricular Function in Left Ventricular Assist Device Support: A Tale of Two Echo Parameters. Journal of the American Society of Echocardiography, Minneapolis Minnesota July 2013.

Atluri P, Goldstone AB, Kobrin DM, Cohen JE, MacArthur JW, Howard JL, Jessup ML, Rame JE, Acker MA, Woo YJ. : Ventricular assist device implant in the elderly is associated with increased, but respectable risk: a multi-institutional study. The Annals of thoracic surgery 96(1): 141-7, Jul 2013.

Pedrotty Dawn M, Rame Jesus E, Margulies Kenneth B: Management of ventricular arrhythmias in patients with ventricular assist devices. Current opinion in cardiology 28(3): 360-8, May 2013.

Elinoff JM, Rame JE, Forfia PR, Hall MK, Sun J, Gharib AM, Abd-Elmoniem K, Graninger G, Harper B, Danner RoL, Solomon MA: A pilot study of the effect of spironolactone therapy on exercise capacity and endothelial dysfunction in pulmonary arterial hypertension: study protocol for a randomized controlled trial. Trials 14: 91, April 2013.

Patel AM, Adeseun GA, Ahmed I, Mitter N, Rame JE, Rudnick MR: Renal failure in patients with left ventricular assist devices. Clinical journal of the American Society of Nephrology : CJASN 8(3): 484-96, Mar 2013.

Rossano JW, Kaufman BD, Rame JE: Ethical considerations related to the use of mechanical support in congenital heart disease. World journal for pediatric & congenital heart surgery 4(1): 70-4, Jan 2013.

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Last updated: 07/23/2014
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