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J. Eduardo Rame, M.D., M.Phil

J. Eduardo Rame, M.D., M.Phil

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Assistant Professor of Medicine at the Hospital of the University of Pennsylvania
Department: Medicine

Contact information
Penn Medicine
Heart Failure, Mechanical Assist and Cardiac Transplant Center
Hospital of the University of Pennsylvania
2 East, Perelman Center for Advanced Medicine
3400 Civic Center Boulevard
Philadelphia, PA 19104
Office: 215-615-7949
Fax: 215-349-5603
Education:
B.S., M.S. (Molecular Biophysics and Biochemistry)
Yale College, 1990.
M.Phil (Statistics/Health Services Research)
Oxford University , 1996.
M.D. (Medicine)
Harvard Medical School , 1997.
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Description of Clinical Expertise

I am cardiovascular specialist in the area of cardiomyopathy, chronic heart faiure, and pulmonary hypertension, focusing my clinical efforts in the more advanced stage of right and left heart failure syndromes. I am the current medical director of the mechanical circulatory support device program at the University of Pennsylvania and the clinical expertise that I bring to this program specifically involves phenotyping right ventricular function and right ventricular reserve in chronic heart failure. As a practitioner in various disease states causing pulmonary hypertension, I also have developed an expertise in characterizing right ventricular dysfunction due to RV-PA uncoupling in high pulmonary afterload syndrome (PAH).

In the area of advanced heart failure and Left ventricular assist device support (LVAD), I also bring a specialized program of myocardial recovery by optimizing the degree of mechanical unloading with a LVAD and maximizing the medical therapy that can be tolerated in an effort to drive the process of reverse myocardial remodeling to improve heart function. This is a highly specialized area in the field of advanced heart failure with only a handful of centers world-wide providing this therapeutic approach to their patients.

Description of Research Expertise

My role as an advanced heart failure clinician-scientist and director of the mechanical assist device program at Penn is to provide expertise in the area of myocardial failure in the more advanced stage of this syndrome. More recently I have been working on the emerging interface of metabolism and heart failure. The current focus of my research is the investigation of myocardial and systemic metabolism in the syndrome of chronic heart failure. Specifically, myocardial and systemic insulin resistance is being increasingly targeted as a mechanism of disease progression in chronic heart failure and the objectives as a translational researcher within my group have been to: 1. Understand the role of lipid and adipocytokine biology (leptin, adiponectin, resistin) in the emerging metabolic phenotype of heart failure; 2. Identify specific targets for improving myocardial energetics and whole-body metabolism in cardiomyopathic failure; and 3. Test the safety and efficacy through carefully designed pilot studies of “reversing” specific metabolic pathways which have been dysregulated in human heart failure. My collaborative network for this research currently includes the laboratories of Dr. Tim McGraw, Dr. Richard Shannon, Dr. Ken Margulies and Dr. Tom Cappola within my own group at Penn as well as the laboratory of Dr. Christian Schulze and Professor Ira Goldberg at Columbia University.

Selected Publications

E. Wilson Grandin, Gregory S. Troutman, Payman Zamani, Jeremy A. Mazurek, Ryan J. Tedford, Anjali Vaidya, Julio Chirinos, Pavan Atluri, Ken Margulies, Paul Forfia, J. Eduardo Rame : Indices of Pulsatile and Resistive Afterload and Load-Dependent and Load-Independent Right Ventricular Dysfunction in HFrEF. J. Cardiac Failure September 2015 Notes: Presented at the Heart Failure Society of America (HFSA).

McCarthy Fenton H, Kobrin Dale, Rame J Eduardo, Groeneveld Peter W, McDermott Katherine M, Atluri Pavan, Acker Michael A, Desai Nimesh D: Increasing Frequency of Left Ventricular Assist Device Exchanges in the United States. The Annals of thoracic surgery Jul 2015.

James N Kirkpatrick, Georg Wieselthaler, Martin Strueber, Martin G St John Sutton, J Eduardo Rame : Ventricular assist devices for treatment of acute heart failure and chronic heart failure. Heart 101(14): 1091-6, July 2015.

Bedi K, Snyder NS, Brandimarto J, Mesaros C, Worth A, Blair IA, Margulies KM, Rame JE: End-Stage Human Heart Failure is Characterized by A Deficit in Energetic Lipids in Both Diabetic and Non-Diabetic Patients. Circulation Research July 2015 Notes: Presented at the AHA BCVS Conference, New Orleans LA. Awarded top 10% of Accepted Abstracts and to be Presented at the 2015 Scientific Sessions of the American Heart Association in Orlando.

Kirkpatrick James N, Wieselthaler Georg, Strueber Martin, St John Sutton Martin G, Rame J Eduardo: Ventricular assist devices for treatment of acute heart failure and chronic heart failure. Heart (British Cardiac Society) 101(14): 1091-6, Jul 2015.

Birks EJ, S. Drakos, C. Selzman, R. Starling, C. Cunningham, M. Slaughter, D. M. Spevack, A. Salahuddin, P. Alturi, J. Um, B. Lowes, S. Patel, D. Farrar, F. Kallel, J. E. Rame: Remission From Stage D Heart Failure (RESTAGE-HF): Early Results From a Prospective Multi-Center Study of Myocardial Recovery J. Heart and Lung Transplant April 2015 Notes: Oral Presentation at the International Society of Heart Lung Transplant Meeting, Nice France.

Grandin EW, Mazurek J, Birati E, Vorovich E,Margulies KM, Atluri A, Rame JE : Decreased Pulmonary Artery Compliance is Associated with Right Heart Failure and Reduced 6-Month Survival After Left Ventricular Assist Device. J.Heart Lung Transplant April 2015 Notes: Presented at the International Society of Heart Lung Transplantation, Nice France.

Edo Y. Birati, Thomas C. Hanff, Jeremy A. Mazurek, Sourin Banerji, E. Wilson Grandin, Dawn Pedrotty, Esther Vorovich, Jessica L. Howard, Michael Acker, James N. Kirkpatrick, Lee R. Goldberg, Pavan Atluri, Mariel Jessup, Kenneth B. Margulies and J. Eduardo Rame : The Effect of Pre and Post Implant Anemia on Outcomes of Patients with Left Ventricular Assist Device J. Heart and Lung Transplantation April 2015 Notes: Oral Presentation at the International Society of Heart Lung Transplantation, Nice France.

Rame JE, Bedi K, Snyder N, Brandimarto J, Mesaros C, Blair I, Margulies KM: Myocardial Lipid Metabolism in the End-Stage Failing Heart: Evidence for An Energy-Starved State. J. Heart and Lung Transplant April 2015 Notes: Oral Presentation at the International Society of Heart Lung Transplant, Nice France.

J. Eduardo Rame, Jeffrey J. Teuteberg, Emma Birks, Joseph Rogers, Michael Acker, Edo Birati, Mark S. Slaughter, Keith Aaronson, Katrin Leadley, Francis Pagani, and Robert Kormos : An Analysis of Early Versus Late Right Heart Failure with an Intrapericardial Continuous-Flow LVAD: The ADVANCE Trial. J. Heart Lung Transplant April 2015 Notes: Oral Presentation at the Annual Meeting of the International Society of Heart Lung Transplant, Nice France.

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Last updated: 08/27/2015
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