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J. Eduardo Rame, M.D., M.Phil

J. Eduardo Rame, M.D., M.Phil

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Assistant Professor of Medicine at the Hospital of the University of Pennsylvania
Department: Medicine

Contact information
Penn Medicine
Heart Failure, Mechanical Assist and Cardiac Transplant Center
Hospital of the University of Pennsylvania
2 East, Perelman Center for Advanced Medicine
3400 Civic Center Boulevard
Philadelphia, PA 19104
Office: 215-615-7949
Fax: 215-349-5603
B.S., M.S. (Molecular Biophysics and Biochemistry)
Yale College, 1990.
M.Phil (Statistics/Health Services Research)
Oxford University , 1996.
M.D. (Medicine)
Harvard Medical School , 1997.
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Description of Clinical Expertise

I am cardiovascular specialist in the area of cardiomyopathy, chronic heart faiure, and pulmonary hypertension, focusing my clinical efforts in the more advanced stage of right and left heart failure syndromes. I am the current medical director of the mechanical circulatory support device program at the University of Pennsylvania and the clinical expertise that I bring to this program specifically involves phenotyping right ventricular function and right ventricular reserve in chronic heart failure. As a practitioner in various disease states causing pulmonary hypertension, I also have developed an expertise in characterizing right ventricular dysfunction due to RV-PA uncoupling in high pulmonary afterload syndrome (PAH).

In the area of advanced heart failure and Left ventricular assist device support (LVAD), I also bring a specialized program of myocardial recovery by optimizing the degree of mechanical unloading with a LVAD and maximizing the medical therapy that can be tolerated in an effort to drive the process of reverse myocardial remodeling to improve heart function. This is a highly specialized area in the field of advanced heart failure with only a handful of centers world-wide providing this therapeutic approach to their patients.

Description of Research Expertise

My role as an advanced heart failure clinician-scientist and director of the mechanical assist device program at Penn is to provide expertise in the area of myocardial failure in the more advanced stage of this syndrome. More recently I have been working on the emerging interface of metabolism and heart failure. The current focus of my research is the investigation of myocardial and systemic metabolism in the syndrome of chronic heart failure. Specifically, myocardial and systemic insulin resistance is being increasingly targeted as a mechanism of disease progression in chronic heart failure and the objectives as a translational researcher within my group have been to: 1. Understand the role of lipid and adipocytokine biology (leptin, adiponectin, resistin) in the emerging metabolic phenotype of heart failure; 2. Identify specific targets for improving myocardial energetics and whole-body metabolism in cardiomyopathic failure; and 3. Test the safety and efficacy through carefully designed pilot studies of “reversing” specific metabolic pathways which have been dysregulated in human heart failure. My collaborative network for this research currently includes the laboratories of Dr. Tim McGraw, Dr. Richard Shannon, Dr. Ken Margulies and Dr. Tom Cappola within my own group at Penn as well as the laboratory of Dr. Christian Schulze and Professor Ira Goldberg at Columbia University.

Selected Publications

Edo Y. Birati, Ylenia Quiaoit, Joyce Wald, James N. Kirkpatrick, Lee R. Goldberg, Pavan Atluri, Kenneth B. Margulies, J. Eduardo Rame: Ventricular Assist Device Thrombosis: A Wide Spectrum of Clinical Presentation. The Journal of Heart and Lung Transplantation 34(4): 613, April 2015 Notes: Published online: December 23, 2014.

Burkhoff D, Maurer MS, Joseph SM, Rogers JG, Birati EY, Rame JE, Shah SJ: Left atrial decompression pump for severe heart failure with preserved ejection fraction: theoretical and clinical considerations. JACC Heart Fail 3(4): 275-283, April 2015.

Birati EY, Rame JE: Diagnosis and Management of LVAD Thrombosis. Curr Treat Options Cardiovasc Med 17(2): 361, February 2015.

James N Kirkpatrick, Georg Wieselthaler, Martin Strueber, Martin G St John Sutton, J Eduardo Rame : Ventricular assist devices for treatment of acute heart failure and chronic heart failure. Heart EPUB ahead of print 2015.

Jeffrey J Teuteberg, MD, Mark S Slaughter, MD, Joseph G Rogers, MD, Edwin C McGee, MD, Francis D Pagani, MD, PhD, Robert Gordon, MD, Eduardo Rame, MD, Michael Acker, MD, Robert L Kormos, MD, Christopher Salerno, MD, Thomas P Schleeter, MD, Daniel J Goldstein, MD, Julia Shin, MD, Randall C Starling, MD MPH, Thomas Wozniak, MD, Adnan S Malik, MD, Scott Silvestry, MD, Gregory A Ewald, MD, Ulrich P Jorde, MD, Yoshifumi Naka, MD, PhD, Emma Birks, MD, PhD, Kevin B Najarian, MS, David R Hathaway, MD and Keith D Aaronson, MD, MS : The HVAD Left Ventricular Assist Device: Risk Factors for Neurologic Events and Preventative Mitigation Strategies. JACC Heart Failure EPUB Ahead of Print 2015.

Ascheim DD, Gelijns AC, Goldstein D, Moye LA, Smedira N, Lee S, Klodell CT, Szady A, Parides MK, Jeffries NO, Skerrett D, Taylor DA, Rame JE, Milano C, Rogers JG, Lynch J, Dewey T, Eichhorn E, Sun B, Feldman D, Simari R, O'Gara PT, Taddei-Peters WC, Miller MA, Naka Y, Bagiella E, Rose EA, Woo YJ: Mesenchymal precursor cells as adjunctive therapy in recipients of contemporary left ventricular assist devices. Circulation 129(22): 2287-96, Jun 2014 Notes: Epub 2014 Mar 28.

Birati EY, Kirkpatrick JN, Rame JE, Bala R, Margulies KB.: Dynamic left ventricular assist device inflow obstruction. Circ Heart Fail 7(1): 225-6, Jan 2014

Santangeli P, Muser D, Zado ES, Magnani S, Khetpal S, Hutchinson MD, Supple G, Frankel DS, Garcia FC, Bala R, Riley MP, Lin D, Rame JE, Schaller R, Dixit S, Marchlinski FE, Callans DJ. : Acute Hemodynamic Decompensation during Catheter Ablation of Scar-Related VT: Incidence, Predictors and Impact on Mortality. Circ Arrhythm Electrophysiol Dec 2014.

Lee R*, Xu B*, Rame JE*, Felkin LE, Barton P, Dries DL: Regulated inositol-requiring protein 1-dependent decay as a mechanism of corin RNA and protein deficiency in advanced human systolic heart failure. J Am Heart Assoc. 3(6), Dec 2014.

Edo Y. Birati, Ylenia Quiaoit, Joyce Wald, James N. Kirkpatrick, Lee R. Goldberg, Pavan Atluri, Kenneth B. Margulies, J. Eduardo Rame: Ventricular Assist Device Thrombosis: A Wide Spectrum of Clinical Presentation. Journal of Heart and Lung Transplantation Dec 2014 Notes: Publication stage: In Press Accepted Manuscript The Journal of Heart and Lung Transplantation Published online: December 23, 2014

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Last updated: 06/21/2015
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