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Deepak Nihalani, PhD

Deepak Nihalani, PhD

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Research Assistant Professor of Medicine
Department: Medicine

Contact information
Renal-Electrolyte and Hypertension Division
726 CRB
415 Curie Blvd
Philadelphia, PA 19104
Office: 215-898-0192
Fax: 215-898-0189
Education:
BS (Microbiology)
Delhi University, India, 1990.
MSc (Microbiology)
Delhi University, India, 1992.
PhD (Biotechnology)
Panjab University, Chandigarh, India, 1998.
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Description of Research Expertise

Glomerular Diseases that affect kidney function such as diabetes and hypertension are major causes of ESRD (end stage renal disease) in the United States. Glomerular dysfunction leading to proteinuria and loss of kidney function is major cause of morbidity and mortality among kidney patients. Therefore, studies aimed at understanding the molecular events leading to proteinuria are important in developing therapeutic approaches towards prevention of ESRD. I was quite fascinated by the complexity of the filtration system that is unique in its structural and protein composition. Many studies have now established that podocytes and their specialized junctions commonly known as slit diaphragm are are physical barrier that perform the filtration function of kidney. It has been my long term goal to understand the molecular organization of this filtration assembly of the kidney. The current focus of my lab is to understand the dynamic changes in the slit diaphragm proteins that are induced in response to various glomerular disorders. Many slit diaphragm proteins including Neph1 and Nephrin have been identified that are localized at these junctions suggesting an active role for these proteins and their complexes in molecular events that regulate the integrity of slit diaphragm. My laboratory was the first to identify a novel interaction between Neph1 and the motor protein Myo1c, which we propose is involved in the organization of Neph1 complex during glomerular injury. We utilize modern microscopic, cell culture and animal models to investigate the role of Neph1 and other slit diaphragm proteins in podocyte biology. Our studies provide data on the critical molecular events leading to podocyte effacement and podocyte recovery during an injury/recovery event. Importantly, defining these critical molecular changes and their regulation will reveal novel therapeutic approaches aimed at reducing glomerular injury and improving recovery from a glomerular injury.

Selected Publications

George B, Fan Q, Dlugos CP, Soofi AA, Zhang J, Verma R, Park TJ, Wong H, Curran T, Nihalani D, Holzman LB: Crk1/2 and CrkL form a hetero-oligomer and functionally complement each other during podocyte morphogenesis. Kidney International. Nature Publishing Group, 85(6): 1382-94, June 2014.

Arif E, Rathore YS, Kumari B, Ashish F, Wong HN, Holzman LB, Nihalani D.: Slit diaphragm protein Neph1 and its signaling: a novel therapeutic target for protection of podocytes against glomerular injury. Journal Of Biological Chemistry 289(14): 9502-18, April 2014.

Christopher M. Furcht, Andres Muñoz Rojas, Deepak Nihalani, and Matthew J. Lazzara: Diminished functional role and altered localization of shp2 in non-small cell lung cancer cells with EGFR-activating mutations. Oncogene doi: 10.1038/onc.2012.240: doi: 10.1038/onc.2012.240, May 2013.

Tiwari A, Jung JJ, Inamdar SM, Nihalani D, Choudhury A: The myosin motor Myo1c is required for VEGFR2 delivery to the cell surface and for angiogenic signaling. Am J Physiol Heart Circ Physiol. Am J Physiol Heart Circ Physiol 304(5), 2013.

Duncan B Johnstone, Vijay Shegokar, Deepak Nihalani, Yogendra Singh Rathore, Leena Mallik, Ashish, Vasant Zare, H. Omer Ikizler, Rajaram Powar, and Lawrence B Holzman: APOL1 null alleles from a rural village in India do not correlate with glomerulosclerosis. PLoS ONE 2013.

Ehtesham Arif and Deepak Nihalani: Glomerular Filtration Barrier Assembly. Journal of Postdoctoral Research 2013.

Ehtesham Arif, Babita Kumari, Mark C. Wagner, Weibin Zhou, Lawrence B Holzman, and Deepak Nihalani: Myo1c, an Unconventional Myosin Required for Zebrafish Glomerular Development. Kidney International 2013.

Deepak Nihalani and Katalin Susztak: Sirt1-claudin 1 crosstalk in regulating renal function. Nature Medicine 19(11), 2013.

Martin Helmstädter, Kevin Lüthy, Markus Gödel, Matias Simons, Ashish, Deepak Nihalani, Stefan A. Rensing, Karl-Friedrich Fischbach, Tobias B. Huber: Functional Study of Mammalian Neph Proteins in Drosophila melanogaster. PLoS ONE 7, July 2012.

Mallik L, Arif E, Sharma P, Rathore YS, Wong HN, Holzman LB, Ashish, Nihalani D: Solution structure analysis of cytoplasmic domain of podocyte protein Neph1 using small/wide angle x-ray scattering (SWAXS). The Journal of Biological Chemistry 287(12): 9441-53, Mar 2012.

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Last updated: 07/15/2014
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