Ekaterina L. Grishchuk, Ph.D.
Ekaterina L. Grishchuk, Ph.D.
Assistant Professor of Physiology
Department: Physiology
Graduate Group Affiliations
Contact information
Physiology Department
School of Medicine
University of Pennsylvania
A401 Richards Building
3700 Hamilton Walk
Philadelphia, PA 19104
School of Medicine
University of Pennsylvania
A401 Richards Building
3700 Hamilton Walk
Philadelphia, PA 19104
Office: (215) 746-8178
Fax: (215) 573-2273
Fax: (215) 573-2273
Email:
gekate@mail.med.upenn.edu
gekate@mail.med.upenn.edu
Publications
Education:
M.S. (Physics, specialization in Biophysics)
Moscow State University, Department of Physics, Moscow, Russia, 1990.
Ph.D. (Molecular, Cellular and Developmental Biology)
Molecular, Cellular and Developmental Biology Department, University of Colorado, Boulder, USA, 1997.
Permanent linkM.S. (Physics, specialization in Biophysics)
Moscow State University, Department of Physics, Moscow, Russia, 1990.
Ph.D. (Molecular, Cellular and Developmental Biology)
Molecular, Cellular and Developmental Biology Department, University of Colorado, Boulder, USA, 1997.
Description of Research Expertise
Mechanisms that drive and control chromosome motions in mitosisSelected Publications
Grishchuk Ekaterina L, Ataullakhanov Fazly I: In vitro assays to study the tracking of shortening microtubule ends and to measure associated forces. Methods in Cell Biology. Elsevier, 95: 657-76, May 2010.McIntosh JR, Volkov V, Ataullakhanov FI, Grishchuk EL: Tubulin depolymerization may be an ancient biological motor. Journal of Cell Science 123(Pt20): 3425-34. Oct 2010.
Grishchuk Ekaterina L: Toward a comprehensive and quantitative understanding of intracellular microtubule organization. Molecular systems biology 5: 251, Mar 2009.
Welburn Julie P I, Grishchuk Ekaterina L, Backer Chelsea B, Wilson-Kubalek Elizabeth M, Yates John R, Cheeseman Iain M: The human kinetochore Ska1 complex facilitates microtubule depolymerization-coupled motility. Developmental cell 16(3): 374-85, Mar 2009.
Grishchuk Ekaterina L, Efremov Artem K, Volkov Vladimir A, Spiridonov Ilia S, Gudimchuk Nikita, Westermann Stefan, Drubin David, Barnes Georjana, McIntosh J Richard, Ataullakhanov Fazly I: The Dam1 ring binds microtubules strongly enough to be a processive as well as energy-efficient coupler for chromosome motion. Proceedings of the National Academy of Sciences of the United States of America 105(40): 15423-8, Oct 2008.
McIntosh J Richard, Grishchuk Ekaterina L, Morphew Mary K, Efremov Artem K, Zhudenkov Kirill, Volkov Vladimir A, Cheeseman Iain M, Desai Arshad, Mastronarde David N, Ataullakhanov Fazly I: Fibrils connect microtubule tips with kinetochores: a mechanism to couple tubulin dynamics to chromosome motion. Cell 135(2): 322-33, Oct 2008.
Grishchuk Ekaterina L, Spiridonov Ilia S, Volkov Vladimir A, Efremov Artem K, Westermann Stefan, Drubin David, Barnes Georjana, Ataullakhanov Fazly I, McIntosh J Richard: Different assemblies of the DAM1 complex follow shortening microtubules by distinct mechanisms. Proceedings of the National Academy of Sciences of the United States of America 105(19): 6918-23, May 2008.
Efremov Artem, Grishchuk Ekaterina L, McIntosh J Richard, Ataullakhanov Fazly I: In search of an optimal ring to couple microtubule depolymerization to processive chromosome motions. Proceedings of the National Academy of Sciences of the United States of America 104(48): 19017-22, Nov 2007.
Grishchuk Ekaterina L, McIntosh J Richard: Microtubule depolymerization can drive poleward chromosome motion in fission yeast. The EMBO journal 25(20): 4888-96, Oct 2006.
Grishchuk Ekaterina L, Molodtsov Maxim I, Ataullakhanov Fazly I, McIntosh J Richard: Force production by disassembling microtubules. Nature 438(7066): 384-8, Nov 2005.