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Frederic Bibollet-Ruche, Ph.D.

Frederic Bibollet-Ruche, Ph.D.

faculty photo
Research Assistant Professor of Medicine
Department: Medicine

Contact information
University of Pennsylvania
423A Johnson Pavilion
3610 Hamilton Walk
Philadelphia, PA 19104
Office: 215-573-6462
Education:
M.S. (Biochemistry)
University of Paris VI, Paris, France, 1989.
Ph.D. (Biological Sciences and Molecular Biology)
University of Sciences and Techniques of languedoc, Montpellier II, France, 1996.
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Description of Research Expertise

NGS (Next Generation Sequencing)
Sequencing
HIV-1
HIV-2
Virus isolation
Chimpanzee
Molecular Biology
Cellular Biology

Selected Publications

Cadena Cristhian, Stavrou Spyridon, Manzoni Tomaz, Iyer Shilpa S, Bibollet-Ruche Frederic, Zhang Weiyu, Hahn Beatrice H, Browne Edward P, Ross Susan R: The effect of HIV-1 Vif polymorphisms on A3G anti-viral activity in an in vivo mouse model. Retrovirology 13(1): 45, Jun 30 2016.

Etienne L, Bibollet-Ruche F, Sudmant PH, Wu LI, Hahn BH, Emerman M: The Role of the Antiviral APOBEC3 Gene Family in Protecting Chimpanzees against Lentiviruses from Monkeys. PLoS pathogens 11(9): e1005149, Sep 22 2015.

Barbian HJ, Decker JM, Bibollet-Ruche F, Galimidi RP, West AP Jr, Learn GH, Parrish NF, Iyer SS, Li Y, Pace CS, Song R, Huang Y, Denny TN, Mouquet H, Martin L, Acharya P, Zhang B, Kwong PD, Mascola JR, Verrips CT, Strokappe NM, Rutten L, McCoy LE, Weiss RA, Brown CS, Jackson R, Silvestri G, Connors M, Burton DR, Shaw GM, Nussenzweig MC, Bjorkman PJ, Ho DD, Farzan M, Hahn BH: Neutralization properties of simian immunodeficiency viruses infecting chimpanzees and gorillas. MBio 6(2): e00296-15, Apr 21 2015.

Kluge SF, Mack K, Iyer SS, Pujol FM, Heigele A, Learn GH, Usmani SM, Sauter D, Joas S, Hotter D, Bibollet-Ruche F, Plenderleith LJ, Peeters M, Geyer M, Sharp PM, Fackler OT, Hahn BH, Kirchhoff F: Nef Proteins of Epidemic HIV-1 Group O Strains Antagonize Human Tetherin. Cell host & microbe 16(5): 639-50, Nov 2014.

Liu W, Li Y, Shaw KS, Learn GH, Plenderleith LJ, Malenke JA, Sundararaman SA, Ramirez MA, Crystal PA, Smith AG, Bibollet-Ruche F, Ayouba A, Locatelli S, Esteban A, Mouacha F, Guichet E, Butel C, Ahuka-Mundeke S, Inogwabini BI, Ndjango JB, Speede S, Sanz CM, Morgan DB, Gonder MK, Kranzusch PJ, Walsh PD, Georgiev AV, Muller MN, Piel AK, Stewart FA, Wilson ML, Pusey AE, Cui L, Wang Z, Färnert A, Sutherland CJ, Nolder D, Hart JA, Hart TB, Bertolani P, Gillis A, LeBreton M, Tafon B, Kiyang J, Djoko CF, Schneider BS, Wolfe ND, Mpoudi-Ngole E, Delaporte E, Carter R, Culleton RL, Shaw GM, Rayner JC, Peeters M, Hahn BH, Sharp PM: African origin of the malaria parasite Plasmodium vivax. Nature communications 5: 3346, 2014.

Letko M, Silvestri G, Hahn BH, Bibollet-Ruche F, Gokcumen O, Simon V, Ooms M: Vif proteins from diverse primate lentiviral lineages use the same binding site in APOBEC3G. Journal of virology 87(21): 11861-71, Nov 2013.

Kluge SF, Sauter D, Vogl M, Peeters M, Li Y, Bibollet-Ruche F, Hahn BH, Kirchhoff F: The transmembrane domain of HIV-1 Vpu is sufficient to confer anti-tetherin activity to SIVcpz and SIVgor Vpu proteins: cytoplasmic determinants of Vpu function. Retrovirology 10: 32, March 20 2013.

Sauter D, Unterweger D, Vogl M, Usmani SM, Heigele A, Kluge SF, Hermkes E, Moll M, Barker E, Peeters M, Learn GH, Bibollet-Ruche F, Fritz JV, Fackler OT, Hahn BH, Kirchhoff F: Human tetherin exerts strong selection pressure on the HIV-1 group N Vpu protein. PLoS pathogens 8(12): e1003093, Dec 2012.

Kong R, Li H, Georgiev I, Changela A, Bibollet-Ruche F, Decker JM, Rowland-Jones SL, Jaye A, Guan Y, Lewis GK, Langedijk JP, Hahn BH, Kwong PD, Robinson JE, Shaw GM: Epitope mapping of broadly neutralizing human HIV-2 monoclonal antibodies. Journal of virology 86(22): 12115-28, Nov 2012.

Li Y, Ndjango JB, Learn GH, Ramirez MA, Keele BF, Bibollet-Ruche F, Liu W, Easlick JL, Decker JM, Rudicell RS, Inogwabini BI, Ahuka-Mundeke S, Leendertz FH, Reynolds V, Muller MN, Chancellor RL, Rundus AS, Simmons N, Worobey M, Shaw GM, Peeters M, Sharp PM, Hahn BH: Eastern chimpanzees, but not bonobos, represent a simian immunodeficiency virus reservoir. Journal of virology 86(19): 10776-91, Oct 2012.

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Last updated: 10/10/2016
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