Elizabeth A Grice, Ph.D.
Elizabeth A Grice, Ph.D.
Assistant Professor of Dermatology
Department: Dermatology
Graduate Group Affiliations
Contact information
415 Curie Blvd
242A Clinical Research Building
Philadelphia, PA 19104
242A Clinical Research Building
Philadelphia, PA 19104
Office: 215-898-3179
Fax: 215-573-2033
Lab: 215-573-1095
Fax: 215-573-2033
Lab: 215-573-1095
Email:
egrice@mail.med.upenn.edu
egrice@mail.med.upenn.edu
Publications
Education:
B.A. (Biology)
Luther College, 2001.
Ph.D. (Human Genetics)
Johns Hopkins University, 2006.
Permanent linkB.A. (Biology)
Luther College, 2001.
Ph.D. (Human Genetics)
Johns Hopkins University, 2006.
Description of Research Expertise
Research Interests:The lab is focused on characterizing host-microbe interactions at the cutaneous surface in health and disease, using genomic approaches.
Keywords:
host-microbe interactions
metagenomic analysis of microbial communities
diabetic ulcers
wound healing
skin disease
innate immunity and cutaneous defense
Lab Personnel:
Amanda Tyldsley, Research Specialist
Geoffrey Hannigan, Ph.D. student, GTV/CAMB
Ana Misic, Ph.D., post-doctoral fellow
Rianne Esquival, rotation student, MVP/CAMB
Selected Publications
Elizabeth A. Grice and Julia A. Segre: The Human Microbiome: Our Second Genome. Annual Review in Genomics and Human Genetics 13, August 2012 Notes: In press.Kong Heidi H, Oh Julia, Deming Clay, Conlan Sean, Grice Elizabeth A, Beatson Melony, Nomicos Effie, Polley Eric, Komarow Hirsh D, Program Nisc Comparative Sequence, Murray Patrick R, Turner Maria L, Segre Julia A: Temporal shifts in the skin microbiome associated with atopic dermatitis disease flares and treatment. Genome research Feb 2012.
Grice Elizabeth A, Segre Julia A: Interaction of the microbiome with the innate immune response in chronic wounds. Advances in Experimental Medicine and Biology 946: 55-68, 2012.
Grice Elizabeth A, Segre Julia A: The skin microbiome. Nature reviews. Microbiology 9(4): 244-53, Apr 2011.
Grice Elizabeth A, Snitkin Evan S, Yockey Laura J, Bermudez Dustin M, , Liechty Kenneth W, Segre Julia A: Longitudinal shift in diabetic wound microbiota correlates with prolonged skin defense response. Proceedings of the National Academy of Sciences of the United States of America 107(33): 14799-804, Aug 2010.
Scharschmidt Tiffany C, List Karin, Grice Elizabeth A, Szabo Roman, , Renaud Gabriel, Lee Chyi-Chia R, Wolfsberg Tyra G, Bugge Thomas H, Segre Julia A: Matriptase-deficient mice exhibit ichthyotic skin with a selective shift in skin microbiota. The Journal of Investigative Dermatology 129(10): 2435-42, Oct 2009.
Grice Elizabeth A, Kong Heidi H, Conlan Sean, Deming Clayton B, Davis Joie, Young Alice C, , Bouffard Gerard G, Blakesley Robert W, Murray Patrick R, Green Eric D, Turner Maria L, Segre Julia A: Topographical and temporal diversity of the human skin microbiome. Science 324(5931): 1190-2, May 2009.
Grice Elizabeth A, Kong Heidi H, Renaud Gabriel, Young Alice C, , Bouffard Gerard G, Blakesley Robert W, Wolfsberg Tyra G, Turner Maria L, Segre Julia A: A diversity profile of the human skin microbiota. Genome research 18(7): 1043-50, Jul 2008.
Fisher Shannon*, Grice Elizabeth A*, Vinton Ryan M, Bessling Seneca L, McCallion Andrew S: Conservation of RET regulatory function from human to zebrafish without sequence similarity. Science 312(5771): 276-9, Apr 2006 Notes: *Equal contributions.
Fisher Shannon*, Grice Elizabeth A*, Vinton Ryan M, Bessling Seneca L, Urasaki Akihiro, Kawakami Koichi, McCallion Andrew S: Evaluating the biological relevance of putative enhancers using Tol2 transposon-mediated transgenesis in zebrafish. Nature Protocols 1(3): 1297-305, 2006 Notes: *Equal contributions.