Evgeniy Eruslanov, PhD
Research Associate Professor of Surgery
Department: Surgery
Contact information
University of Pennsylvania
Department of Surgery
Stemmler Hall
3450 Hamilton Walk, Office 408A
Philadelphia, PA 19104
Department of Surgery
Stemmler Hall
3450 Hamilton Walk, Office 408A
Philadelphia, PA 19104
Office: 610-772-5624
Publications
Education:
MS (Immunology)
Pirogov Russian National Research Medical University, Moscow, Russia, 1999.
PhD (Immunology)
Central Institute for Tuberculosis, Gamaleya’s Institute of Epidemiology and Microbiology Moscow, Russia, 2002.
Permanent linkMS (Immunology)
Pirogov Russian National Research Medical University, Moscow, Russia, 1999.
PhD (Immunology)
Central Institute for Tuberculosis, Gamaleya’s Institute of Epidemiology and Microbiology Moscow, Russia, 2002.
Description of Other Expertise
Description of Research Expertise
According to numerous mouse studies, the protumoral and immunosuppressive role of Tumor-Associated Myeloid Cells in cancer is a dominating concept. However, the characterization of tumor microenvironment in cancer patients is still in its infancy and the functional crosstalk between immune and tumor cells in human remains unexplored. My research interests are directed toward understanding the specific functional and regulatory roles of distinct subsets of tumor-infiltrating neutrophils and macrophages in patients with lung cancer.Selected Publications
Sunil Singhal, Abhishek S. Rao, Jason Stadanlick, Kyle Bruns, Neil T. Sullivan, Andres Bermudez, Adam Honig-Frand, Ryan Krouse, Sachinthani Arambepola, Emily Guo, Edmund K. Moon, George Georgiou, Tomas Valerius, Steven M. Albelda, and Evgeniy B. Eruslanov: Human tumor-associated macrophages and neutrophils regulate anti-tumor antibody efficacy through lethal and sublethal trogocytosis. Cancer Research(doi.org/10.1158/0008-5472), January 2024.3. Quail DF, Amulic B, Aziz M, Barnes BJ, Eruslanov E, Fridlender ZG, Goodridge HS, Granot Z, Hidalgo A, Huttenlocher A, Kaplan MJ, Malanchi I, Merghoub T, Meylan E, Mittal V, Pittet MJ, Rubio-Ponce A, Udalova IA, van den Berg TK, Wagner DD, Wang P, Zychlinsky A, de Visser KE, Egeblad M, Kubes P.J : Neutrophil phenotypes and functions in cancer: A consensus statement. J. Exp Med. (6;219 (6) ), June 2022.
Singhal S, Stadanlick J, Annunziata MJ, Rao AS, Bhojnagarwala PS, O'Brien S, Moon EK, Cantu E, Danet-Desnoyers G, Ra HJ, Litzky L, Akimova T, Beier UH, Hancock WW, Albelda SM, Eruslanov EB: Human tumor-associated monocytes/macrophages and their regulation of T cell responses in early-stage lung cancer. Science Translational Medicine 11(479): eaat1500, Feb. 13 2019.
Singhal S, Bhojnagarwala P, O’Brien S, Moon E, Garfall A, Rao A, Quatromoni J, Stephen T, Litzky L , Deshpande C, Feldman M,Hancock W, Cornejo-Garcia J, Albelda S, Eruslanov E: Origin and role of a subset of tumor-associated neutrophils with antigen presenting cell features in early-stage human lung cancer. Cancer Cell 30(1): 120-135, July 11 2016 Notes: (Epub June 30, 2016).
Eruslanov EB, Bhojnagarwala PS, Quatromoni JG, Stephen TL, Ranganathan A, Deshpande C, Akimova T, Vachani A, Litzky L, Hancock WW, Conejo-Garcia JR, Feldman M, Albelda SM, Singhal S: Tumor-associated neutrophils stimulate T cell responses in early-stage human lung cancer. Journal of Clinical Investigation 124(12): 5466-5480, Dec. 2014 Notes: (Epub Nov. 10, 2014).
Eruslanov EB, Singhal S, and Albelda S: Mouse versus human neutrophils in cancer: A major knowledge gap. Trends in Cancer 3(2): 149-160, Feb. 2017 Notes: (Epub Jan. 19, 2017).
Eruslanov EB: Phenotype and function of tumor-associated neutrophils and their subsets in early-stage human lung cancer. Cancer Immunology Immunotherapy 66(8): 997-1006, Aug. 2017 Notes: (Epub Mar. 10, 2017).
Quatromoni JG, Singhal S, Bhojnagarwala P, Hancock WW, Albelda SM, Eruslanov E: An optimized disaggregation method for human lung tumors that preserves the phenotype and function of the immune cells. Journal of Leukocyte Biology 97(1): 201-209, Jan. 2015 Notes: (Epub Oct. 30, 2014).
Eruslanov E, Stoffs T, Kim WJ, Daurkin I, Gilbert SM, Su LM, Vieweg J, Daaka Y, Kusmartsev S: Expansion of CCR8(+) inflammatory myeloid cells in cancer patients with urothelial and renal carcinomas. Clinical Cancer Research 19(7): 1670-1680, Apr. 2013 Notes: (Epub Jan. 30, 2013).
Quatromoni JG, Eruslanov E: Tumor-associated macrophages: Function, phenotype, and link to prognosis in human lung cancer. American Journal of Translational Research 4(4): 376-389, 2012 Notes: (Epub Oct. 10, 2012).