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Evgeniy Eruslanov, PhD

Evgeniy Eruslanov, PhD

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Research Assistant Professor of Surgery
Department: Surgery

Contact information
Thoracic Surgery Research Laboratory
3400 Spruce Street, 6 Silverstein
Philadelphia, PA 19104
Office: 610-772-5624
Education:
MS (Immunology)
Pirogov Russian National Research Medical University, Moscow, Russia, 1999.
PhD (Immunology)
Central Institute for Tuberculosis, Gamaleya’s Institute of Epidemiology and Microbiology Moscow, Russia, 2002.
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Description of Other Expertise


Description of Research Expertise

According to numerous mouse studies, the protumoral and immunosuppressive role of Tumor-Associated Myeloid Cells in cancer is a dominating concept. However, the characterization of tumor microenvironment in cancer patients is still in its infancy and the functional crosstalk between immune and tumor cells in human remains unexplored. My research interests are directed toward understanding the specific functional and regulatory roles of distinct subsets of tumor-infiltrating neutrophils and macrophages in patients with lung cancer.

Selected Publications

Singhal S, Bhojnagarwala P, O’Brien S, Moon E, Garfall A, Rao A, Quatromoni J, Stephen T, Litzky L , Deshpande C, Feldman M,Hancock W, Cornejo-Garcia J, Albelda S, Eruslanov E: Origin and role of a subset of tumor-associated neutrophils with antigen presenting cell features in early-stage human lung cancer. Cancer Cell 30: 1-16, July 2016.

Eruslanov EB, Bhojnagarwala PS, Quatromoni JG, Stephen TL, Ranganathan A, Deshpande C, Akimova T, Vachani A, Litzky L, Hancock WW, Conejo-Garcia JR, Feldman M, Albelda SM, Singhal S: Tumor-associated neutrophils stimulate T cell responses in early-stage human lung cancer. Journal of Clinical Investigation 124(12): 5466-5480, Dec. 2014.

Eruslanov EB, Singhal S, and Albelda S. : Mouse versus Human Neutrophils in Cancer: A Major Knowledge Gap. Trends in Cancer 3(2): 149-160, Feb 2017.

Quatromoni JG, Singhal S, Bhojnagarwala P, Hancock WW, Albelda SM, Eruslanov E: An optimized disaggregation method for human lung tumors that preserves the phenotype and function of the immune cells. Journal of Leukocyte Biology 9(7), Oct. 2014.

Eruslanov E, Stoffs T, Kim WJ, Daurkin I, Gilbert SM, Su LM, Vieweg J, Daaka Y, Kusmartsev S: Expansion of CCR8(+) inflammatory myeloid cells in cancer patients with urothelial and renal carcinomas. Clinical Cancer Research 19(7): 1670-1680, Apr. 2013.

Eruslanov E, Neuberger M, Daurkin I, Perrin GQ, Algood C, Dahm P, Rosser C, Vieweg J, Gilbert SM, Kusmartsev S: Circulating and tumor-infiltrating myeloid cell subsets in patients with bladder cancer. International Journal of Cancer 130(5): 1109-1119, Mar. 2012.

Quatromoni JG, Eruslanov E: Tumor-associated macrophages: Function, phenotype, and link to prognosis in human lung cancer. American Journal of Translational Research 4(4): 376-389, 2012.

Daurkin I*, Eruslanov E*,(equal contribution) Stoffs T, Perrin GQ, Algood C, Gilbert SM, Rosser CJ, Su LM, Vieweg J, Kusmartsev S: Tumor-associated macrophages mediate immunosuppression in the renal cancer microenvironment by activating the 15-lipoxygenase-2 pathway. Cancer Research 71(20): 6400-6409, Oct. 2011.

Eruslanov E, Daurkin I, Ortiz J, Vieweg J, Kusmartsev S: Pivotal advance: Tumor-mediated induction of myeloid-derived suppressor cells and M2-polarized macrophages by altering intracellular PGE₂ catabolism in myeloid cells. Journal of Leukocyte Biology 88(5): 839-848, Nov. 2010.

Eruslanov E, Kaliberov S, Daurkin I, Kaliberova L, Buchsbaum D, Vieweg J, Kusmartsev S: Altered expression of 15-hydroxyprostaglandin dehydrogenase in tumor-infiltrated CD11b myeloid cells: A mechanism for immune evasion in cancer. Journal Immunology 182(12): 7548-7557, June 2009.

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Last updated: 08/01/2017
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