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Arturo Loaiza-Bonilla, MD, FACP

Arturo Loaiza-Bonilla, MD, FACP

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Assistant Professor of Clinical Medicine
Department: Medicine

Contact information
Division of Hematology/Oncology
Perelman Center for Advanced Medicine
6th Floor South Pavilion
3400 Civic Center Boulevard
Abramson Cancer Center
Philadelphia, PA 19104
Office: 215-615-5810
Education:
MD (Medical Doctor and Surgeon)
Universidad Nacional de Colombia (Bogota, Colombia), 2004.
M.S.Ed. (Master in Medical Education)
University of Pennsylvania Graduate School of Education, 2016.
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Description of Clinical Expertise

I specialize in clinical and transitional research trials as well as the multidisciplinary, comprehensive care of patients suffering from gastrointestinal malignancies, with particular emphasis in pancreatic, hepatobiliary, colorectal, upper digestive, GIST, adrenal and neuroendocrine cancers (including PNET, pheochromocytoma and paraganglioma).

Using Penn Medicine's state-of-the-art, evidence-based and patient-centered approach, I integrate next-generation personalized molecular diagnostics (CPD testing), immunotherapy, comorbidity, previous therapies and the patient's overall status into decision making for optimal outcomes. I also provide expert second opinions (locally and internationally through Penn Global Medicine), clinical trial guidance, as well as recommendations regarding personalized cancer genomics, and the concomitant use of complementary medicine and integrative oncology measures.

Description of Research Expertise

Phase I/III trials in gastrointestinal malignancies, with emphasis in new targeted therapies, novel molecules and immunotherapy, tailored to specific tumor type, its genomics and tumor genetic information from the Penn's center of personalized diagnostics. I am principal and co-investigator of multiple studies, including active participation at the Eastern Cooperative Oncology Group (ECOG).

Selected Publications

Loaiza-Bonilla A, Kittaneh M, Guardiola Amado VD, Kovacs K, Merchan JR.: Preclinical study of cytotoxicity and predictive markers of response to dual inhibition of PI3K and mTORC1/2 signaling by NVP-BEZ235 with or without paclitaxel or nab-paclitaxel as a new therapeutic strategy in pancreatic cancer cell lines. J Clin Oncol (ASCO Annual Meeting Abstracts) June 2013 Notes: Poster presentation

Arturo Loaiza-Bonilla, Mark H. O'Hara, Maryann Redlinger, Nevena Damjanov, Ursina R. Teitelbaum, Irina Vasilevskaya, Mark Alan Rosen, Daniel F Heitjan, Ravi K. Amaravadi, Peter J. O'Dwyer: Phase II trial of autophagy inhibition using hydroxychloroquine (HCQ) with FOLFOX/bevacizumab in the first-line treatment of advanced colorectal cancer. J Clin Oncol 33(15): abstr 3614, May 2015 Notes: 2015 ASCO Annual Meeting; Poster presentation.

Loaiza-Bonilla Arturo, Clayton Erica, Furth Emma, O'Hara Mark and Morrissette Jennifer : Dramatic response to dabrafenib and trametinib combination in a BRAF V600E-mutated cholangiocarcinoma: implementation of a molecular tumour board and next-generation sequencing for personalized medicine. ecancer 8(497), November 2014.

Peter J. Hosein, Ana Echenique, Arturo Loaiza-Bonilla, Tatiana Froud, Katuzka Barbery, Caio M. Rocha Lima, Jose M. Yrizarry, Govindarajan Narayanan: Percutaneous irreversible electroporation for the treatment of colorectal cancer liver metastases with a proposal for a new response evaluation system. J Vasc Interv Radiol. Page: pii: S1051-0443(14)00442-4. May 2014.

Hosein Peter J, Macintyre Jessica, Kawamura Carolina, Maldonado Jennifer Cudris, Ernani Vinicius, Loaiza-Bonilla Arturo, Narayanan Govindarajan, Ribeiro Afonso, Portelance Lorraine, Merchan Jaime R, Levi Joe U, Rocha-Lima Caio M: A retrospective study of neoadjuvant FOLFIRINOX in unresectable or borderline-resectable locally advanced pancreatic adenocarcinoma. BMC Cancer 12: 199, May 2012.

Sofia Palacio, Arturo Loaiza-Bonilla, Muaiad Kittaneh, Christos Kyriakopoulos, Roberto E. Ochoa, Mauricio Escobar, Belisario Arango, Maria H. Restrepo, Jaime R. Merchan, Caio M.S. Rocha Lima, Peter J. Hosein: Successful Use of Trastuzumab with Anthracycline-based Chemotherapy Followed by Trastuzumab Maintenance in Patients with Advanced HER2-positive Gastric Cancer. Anticancer Research 34(1): 301-306, January 2014.

Moh'd M. Khushman, Peter Joel Hosein, Michel Velez, Lauren Carcas, Daniel Joseph Dammrich, Jorge Hurtado-Cordovi, Ritesh Parajuli, Terri Pollack, Jessica Macintyre, Ana Paula P. Harwood, Arturo Loaiza-Bonilla, Ikechukwu Immanuel Akunyili, Maria H. Restrepo, Jaime R. Merchan, Govindarajan Narayanan, Lorraine Portelance, Danny Sleeman, Joe U Levi, Caio Max S. Rocha Lima: Updated survival analysis of patients (pts) with unresectable (UR) or borderline resectable (BR) locally advanced pancreatic adenocarcinoma (LAPC) treated with neoadjuvant FOLFIRINOX. J Clin Oncol (ASCO Annual Meeting Abstracts) 32: suppl; abstr e15197, June 2014 Notes: Poster presentation

Loaiza-Bonilla A, Artz A, Salerno F, Leng SX, Yeh S, Biedenbender R, Gravenstein S, Loera J, Geloo ZS and Ershler WB: Correction of Anemia in the Frail Elderly (CAFE): Results of a Randomized, Double-Blind, Placebo-Controlled Study with Darbepoetin Alfa in Elderly Patients with Chronic Unexplained Anemia. Poster Blood 120(21): 5153, Nov 2012 Notes: Poster presentation

Socola F, Loaiza-Bonilla A, Benedetto P: Axitinib Induced Recurrent Pneumothorax following Near-Complete Response of Renal Cell Carcinoma Lung Metastasis: An Unexpected Complication. Case Rep Oncol Med. December 2012 Notes: Article ID 390702, 5 pages, doi:10.1155/2012/390702.

Socola F, Loaiza-Bonilla A, Bustinza-Linares E, Correa R, Rosenblatt JD: Recurrent thrombotic thrombocytopenic purpura-like syndrome as a paraneoplastic phenomenon in malignant peritoneal mesothelioma: a case report and review of the literature. Case Reports In Oncological Medicine 2012: 619348, October 2012.

Mark H. O'Hara, Maryann Gallagher, Ursina R. Teitelbaum, Bruce J. Giantonio, Nevena Damjanov, Arturo Loaiza-Bonilla, Ravi K. Amaravadi, Daniel F Heitjan, Irina Vasilevskaya, Daniel D. Von Hoff, Ramesh K Ramanathan, Dan Laheru, Ana De Jesus-Acosta, Victor E Velculescu, Peter J. O'Dwyer: Phase 1 trial of gemcitabine/nab-paclitaxel in combination with the autophagy inhibitor hydroxychloroquine in previously untreated patients with metastatic pancreatic adenocarcinoma. J Clin Oncol (ASCO Meeting Abstracts) 33: e15213, May 2015 Notes: 2015 ASCO Annual Meeting, (suppl; abstr e15213); Poster presentation.

P. J. Hosein, C. Kawamura, J. Macintyre, A. Loaiza-Bonilla, J. R. Merchan, J. U. Levi, C. S. Rocha Lima.: Pilot study of neoadjuvant FOLFIRINOX in unresectable locally advanced (LA) pancreatic carcinoma (PC). J Clin Oncol 29: suppl 4; abstr 324, January 2011 Notes: 2011 Gastrointestinal Cancers Symposium.

Loaiza-Bonilla A, Gluck S.: Using modern molecular markers to tailor breast cancer treatment: a new era for personalized medicine. Breast Cancer Management 1(2): 105-108, Jul 2012.

Loaiza-Bonilla Arturo, Rossi Flavia, Alkhalil Bassel: Tracheal carcinoid presenting as refractory cervicalgia in a postpartum patient: correlation versus epiphenomenon. Ear, Nose, & Throat Journal 91(9): E11-4, Sep 2012.

Loaiza-Bonilla A, Socola F, Gluck S: Clinical utility of aromatase inhibitors as adjuvant treatment in postmenopausal breast cancer. Clinical Medicine Insights: Women's Health 6: 1-11, Jan 22 2013 Notes: doi: 10.4137/CMWH.S8692.

Arturo Loaiza-Bonilla, Katuska J Barbery, Evelyn Perez-Rojas, Tatiana Froud, Jose M Yrizarry, Ikechukwu Immanuel Akunyili, Caio Max S. Rocha Lima, Lynn G. Feun, Peter Joel Hosein, Govindarajan Narayanan.: Percutaneous irreversible electroporation (IRE) in the treatment of hepatocellular carcinoma (HCC) and metastatic colorectal cancer (mCRC) to the liver: A retrospective analysis of the University of Miami experience. J Clin Oncol (ASCO Annual Meeting Abstracts) 30: suppl 4; abstr 272, January 2012 Notes: Poster presentation

Bojanini Esteban Uribe, Loaiza-Bonilla Arturo, Pimentel Agustin: Prekallikrein deficiency presenting as recurrent cerebrovascular accident: case report and review of the literature. Case Reports In Hematology 2012: 723204, August 2012.

Schaefer Eric W, Loaiza-Bonilla Arturo, Juckett Mark, DiPersio John F, Roy Vivek, Slack James, Wu Wenting, Laumann Kristina, Espinoza-Delgado Igor, Gore Steven D: A phase 2 study of vorinostat in acute myeloid leukemia. Haematologica 94(10): 1375-82, Oct 2009.

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Last updated: 08/25/2015
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