Home | News | Directories | Calendar | Maps | Contact Us | Webmail
Perelman School of Medicine at the University of Pennsylvania Advanced Search

Michael Vaclav Holmes, MD, MSc(Epidem), BSc(Hons)

Michael Vaclav Holmes, MD, MSc(Epidem), BSc(Hons)

faculty photo
Research Assistant Professor of Surgery
Department: Surgery

Contact information
Division of Transplant Surgery
Perelman School of Medicine, University of Pennsylvania
3400 Spruce Street, 2 Dulles Pvln
Philadelphia, PA 19104
Education:
BSc(Hons) (Medical Science)
University of St Andrews, 2002.
MBBS (Medicine)
University College London, 2005.
MRCP (Medicine)
Royal College of Physicians, UK, 2009.
MSc (Epidemiology)
London School of Hygeine & Tropical Medicine, 2010.
Permanent link
 
Perelman School of Medicine > Faculty > Search

Description of Research Expertise

Mendelian randomization

Selected Publications

Holmes Michael V, Simon Tabassome, Exeter Holly J, Hingorani Aroon D, Sabatine Marc S, Mallat Ziad, Casas Juan P, Talmud Philippa: Reply to Letter to the Editor: Limits of Mendelian Randomization Analyses in Selection of Secretory Phospholipase A2-IIA as a Valid Therapeutic Target for Cardiovascular Disease Prevention. Journal of the American College of Cardiology Nov 2013.

Holmes Michael V, Bhala Neeraj: The physiological paradox: reframing the polypill as a vaccine for cardiovascular disease. Journal of epidemiology and community health 67(11): 897-902, Nov 2013.

Holmes Michael V, Simon Tabassome, Exeter Holly J, Folkersen Lasse, Asselbergs Folkert W, Guardiola Montse, Cooper Jackie A, Palmen Jutta, Hubacek Jaroslav A, Carruthers Kathryn F, Horne Benjamin D, Brunisholz Kimberly D, Mega Jessica L, van Iperen Erik P A, Li Mingyao, Leusink Maarten, Trompet Stella, Verschuren Jeffrey J W, Hovingh G Kees, Dehghan Abbas, Nelson Christopher P, Kotti Salma, Danchin Nicolas, Scholz Markus, Haase Christiane L, Rothenbacher Dietrich, Swerdlow Daniel I, Kuchenbaecker Karoline B, Staines-Urias Eleonora, Goel Anuj, van 't Hooft Ferdinand, Gertow Karl, de Faire Ulf, Panayiotou Andrie G, Tremoli Elena, Baldassarre Damiano, Veglia Fabrizio, Holdt Lesca M, Beutner Frank, Gansevoort Ron T, Navis Gerjan J, Mateo Leach Irene, Breitling Lutz P, Brenner Hermann, Thiery Joachim, Dallmeier Dhayana, Franco-Cereceda Anders, Boer Jolanda M A, Stephens Jeffrey W, Hofker Marten H, Tedgui Alain, Hofman Albert, Uitterlinden André G, Adamkova Vera, Pitha Jan, Onland-Moret N Charlotte, Cramer Maarten J, Nathoe Hendrik M, Spiering Wilko, Klungel Olaf H, Kumari Meena, Whincup Peter H, Morrow David A, Braund Peter S, Hall Alistair S, Olsson Anders G, Doevendans Pieter A, Trip Mieke D, Tobin Martin D, Hamsten Anders, Watkins Hugh, Koenig Wolfgang, Nicolaides Andrew N, Teupser Daniel, Day Ian N M, Carlquist John F, Gaunt Tom R, Ford Ian, Sattar Naveed, Tsimikas Sotirios, Schwartz Gregory G, Lawlor Debbie A, Morris Richard W, Sandhu Manjinder S, Poledne Rudolf, Maitland-van der Zee Anke H, Khaw Kay-Tee, Keating Brendan J, van der Harst Pim, Price Jackie F, Mehta Shamir R, Yusuf Salim, Witteman Jaqueline C M, Franco Oscar H, Jukema J Wouter, de Knijff Peter, Tybjaerg-Hansen Anne, Rader Daniel J, Farrall Martin, Samani Nilesh J, Kivimaki Mika, Fox Keith A A, Humphries Steve E, Anderson Jeffrey L, Boekholdt S Matthijs, Palmer Tom M, Eriksson Per, Paré Guillaume, Hingorani Aroon D, Sabatine Marc S, Mallat Ziad, Casas Juan P, Talmud Philippa J: Secretory Phospholipase A2-IIA and Cardiovascular Disease: A Mendelian Randomization Study. Journal of the American College of Cardiology 62(21): 1966-76, Nov 2013.

Shah Tina, Zabaneh Delilah, Gaunt Tom, Swerdlow Daniel I, Shah Sonia, Talmud Philippa J, Day Ian N, Whittaker John, Holmes Michael V, Sofat Reecha, Humphries Steve E, Kivimaki Mika, Kumari Meena, Hingorani Aroon D, Casas Juan P: Gene-centric analysis identifies variants associated with interleukin-6 levels and shared pathways with other inflammation markers. Circulation. Cardiovascular genetics 6(2): 163-70, Apr 2013.

Shah Sonia, Casas Juan-Pablo, Drenos Fotios, Whittaker John, Deanfield John, Swerdlow Daniel I, Holmes Michael V, Kivimaki Mika, Langenberg Claudia, Wareham Nick, Gertow Karl, Sennblad Bengt, Strawbridge Rona J, Baldassarre Damiano, Veglia Fabrizio, Tremoli Elena, Gigante Bruna, de Faire Ulf, Kumari Meena, Talmud Philippa J, Hamsten Anders, Humphries Steve E, Hingorani Aroon D: Causal relevance of blood lipid fractions in the development of carotid atherosclerosis: Mendelian randomization analysis. Circulation. Cardiovascular genetics 6(1): 63-72, Feb 2013.

Lum Danny W K, Perel Pablo, Hingorani Aroon D, Holmes Michael V: CYP2D6 genotype and tamoxifen response for breast cancer: a systematic review and meta-analysis. PloS one 8(10): e76648, 2013.

Shah Tina, Engmann Jorgen, Dale Caroline, Shah Sonia, White Jon, Giambartolomei Claudia, McLachlan Stela, Zabaneh Delilah, Cavadino Alana, Finan Chris, Wong Andrew, Amuzu Antoinette, Ong Ken, Gaunt Tom, Holmes Michael V, Warren Helen, Davies Teri-Louise, Drenos Fotios, Cooper Jackie, Sofat Reecha, Caulfield Mark, Ebrahim Shah, Lawlor Debbie A, Talmud Philippa J, Humphries Steve E, Power Christine, Hypponen Elina, Richards Marcus, Hardy Rebecca, Kuh Diana, Wareham Nicholas, Ben-Shlomo Yoav, Day Ian N, Whincup Peter, Morris Richard, Strachan Mark W J, Price Jacqueline, Kumari Meena, Kivimaki Mika, Plagnol Vincent, Dudbridge Frank, Whittaker John C, Casas Juan P, Hingorani Aroon D: Population genomics of cardiometabolic traits: design of the University College London-London School of Hygiene and Tropical Medicine-Edinburgh-Bristol (UCLEB) Consortium. PloS one 8(8): e71345, 2013.

Asselbergs Folkert W, Guo Yiran, van Iperen Erik P A, Sivapalaratnam Suthesh, Tragante Vinicius, Lanktree Matthew B, Lange Leslie A, Almoguera Berta, Appelman Yolande E, Barnard John, Baumert Jens, Beitelshees Amber L, Bhangale Tushar R, Chen Yii-Der Ida, Gaunt Tom R, Gong Yan, Hopewell Jemma C, Johnson Toby, Kleber Marcus E, Langaee Taimour Y, Li Mingyao, Li Yun R, Liu Kiang, McDonough Caitrin W, Meijs Matthijs F L, Middelberg Rita P S, Musunuru Kiran, Nelson Christopher P, O'Connell Jeffery R, Padmanabhan Sandosh, Pankow James S, Pankratz Nathan, Rafelt Suzanne, Rajagopalan Ramakrishnan, Romaine Simon P R, Schork Nicholas J, Shaffer Jonathan, Shen Haiqing, Smith Erin N, Tischfield Sam E, van der Most Peter J, van Vliet-Ostaptchouk Jana V, Verweij Niek, Volcik Kelly A, Zhang Li, Bailey Kent R, Bailey Kristian M, Bauer Florianne, Boer Jolanda M A, Braund Peter S, Burt Amber, Burton Paul R, Buxbaum Sarah G, Chen Wei, Cooper-Dehoff Rhonda M, Cupples L Adrienne, deJong Jonas S, Delles Christian, Duggan David, Fornage Myriam, Furlong Clement E, Glazer Nicole, Gums John G, Hastie Claire, Holmes Michael V, Illig Thomas, Kirkland Susan A, Kivimaki Mika, Klein Ronald, Klein Barbara E, Kooperberg Charles, Kottke-Marchant Kandice, Kumari Meena, LaCroix Andrea Z, Mallela Laya, Murugesan Gurunathan, Ordovas Jose, Ouwehand Willem H, Post Wendy S, Saxena Richa, Scharnagl Hubert, Schreiner Pamela J, Shah Tina, Shields Denis C, Shimbo Daichi, Srinivasan Sathanur R, Stolk Ronald P, Swerdlow Daniel I, Taylor Herman A, Topol Eric J, Toskala Elina, van Pelt Joost L, van Setten Jessica, Yusuf Salim, Whittaker John C, Zwinderman A H, Anand Sonia S, Balmforth Anthony J, Berenson Gerald S, Bezzina Connie R, Boehm Bernhard O, Boerwinkle Eric, Casas Juan P, Caulfield Mark J, Clarke Robert, Connell John M, Cruickshanks Karen J, Davidson Karina W, Day Ian N M, de Bakker Paul I W, Doevendans Pieter A, Dominiczak Anna F, Hall Alistair S, Hartman Catharina A, Hengstenberg Christian, Hillege Hans L, Hofker Marten H, Humphries Steve E, Jarvik Gail P, Johnson Julie A, Kaess Bernhard M, Kathiresan Sekar, Koenig Wolfgang, Lawlor Debbie A, März Winfried, Melander Olle, Mitchell Braxton D, Montgomery Grant W, Munroe Patricia B, Murray Sarah S, Newhouse Stephen J, Onland-Moret N Charlotte, Poulter Neil, Psaty Bruce, Redline Susan, Rich Stephen S, Rotter Jerome I, Schunkert Heribert, Sever Peter, Shuldiner Alan R, Silverstein Roy L, Stanton Alice, Thorand Barbara, Trip Mieke D, Tsai Michael Y, van der Harst Pim, van der Schoot Ellen, van der Schouw Yvonne T, Verschuren W M Monique, Watkins Hugh, Wilde Arthur A M, Wolffenbuttel Bruce H R, Whitfield John B, Hovingh G Kees, Ballantyne Christie M, Wijmenga Cisca, Reilly Muredach P, Martin Nicholas G, Wilson James G, Rader Daniel J, Samani Nilesh J, Reiner Alex P, Hegele Robert A, Kastelein John J P, Hingorani Aroon D, Talmud Philippa J, Hakonarson Hakon, Elbers Clara C, Keating Brendan J, Drenos Fotios: Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. American journal of human genetics 91(5): 823-38, Nov 2012.

Harrison Seamus C, Smith Andrew J P, Jones Gregory T, Swerdlow Daniel I, Rampuri Riaz, Bown Matthew J, Folkersen Lasse, Baas Annette F, de Borst Gert Jan, Blankensteijn Jan D, Price Jacqueline F, van der Graaf Yolanda, McLachlan Stela, Agu Obi, Hofman Albert, Uitterlinden Andre G, Franco-Cereceda Anders, Ruigrok Ynte M, Van't Hof F N, Powell Janet T, van Rij Andre M, Casas Juan P, Eriksson Per, Holmes Michael V, Asselbergs Folkert W, Hingorani Aroon D, Humphries Steve E: Interleukin-6 receptor pathways in abdominal aortic aneurysm. European heart journal Oct 2012.

Harrison Seamus C, Holmes Michael V, Humphries Steve E: Mendelian randomisation, lipids, and cardiovascular disease. Lancet 380(9841): 543-5, Aug 2012.

back to top
Last updated: 12/12/2013
The Trustees of the University of Pennsylvania