Christopher D Watt, MD, PhD
Associate Professor of Clinical Pathology and Laboratory Medicine
Associate Director of the Molecular Pathology Laboratory, Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA
Attending Pathologist, Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA
Molecular Genetic Pathology Program Director , Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA
Department: Pathology and Laboratory Medicine
Contact information
Department of Pathology and Laboratory Medicine
Hospital of the University of Pennsylvania
3400 Spruce Street
Philadelphia, PA 19104
Hospital of the University of Pennsylvania
3400 Spruce Street
Philadelphia, PA 19104
Education:
B.S. (Biology)
University of Kentucky, 1996.
Ph.D. (Cell and Molecular Biology)
Perelman School of Medicine at the University of Pennsylvania, 2005.
M.D. (Medicine)
Perelman School of Medicine at the University of Pennsylvania, 2005.
Permanent linkB.S. (Biology)
University of Kentucky, 1996.
Ph.D. (Cell and Molecular Biology)
Perelman School of Medicine at the University of Pennsylvania, 2005.
M.D. (Medicine)
Perelman School of Medicine at the University of Pennsylvania, 2005.
Description of Clinical Expertise
Molecular PathologySelected Publications
Bakas S, Sako C, Akbari H, Bilello M, Sotiras A, Shukla G, Rudie JD, Santamaría NF, Kazerooni AF, Pati S, Rathore S, Mamourian E, Ha SM, Parker W, Doshi J, Baid U, Bergman M, Binder ZA, Verma R, Lustig RA, Desai AS, Bagley SJ, Mourelatos Z, Morrissette J, Watt CD, Brem S, Wolf RL, Melhem ER, Nasrallah MP, Mohan S, O'Rourke DM, Davatzikos C: The University of Pennsylvania glioblastoma (UPenn-GBM) cohort: advanced MRI, clinical, genomics, & radiomics. Sci Data 9(1), Jul 2022.Nelson N, Priore S, Sondermann J, Herlihy S, Watt CD: Evaluation of Positive Control Material for MGMT Promoter Methylation Studies. Journal of Molecular Diagnostics 23(11): 1618, Nov 2021 Notes: Association for Molecular Pathology 2021 Annual Meeting Abstract [ST17]
Gentile C, Richard-Greenblatt M, Fink J, Elkan M, Harris RM, Van Deerlin VM, Glaser L, Watt CD, Herlihy SE : A Practical Comparison of Seven Molecular SARS-CoV-2 Methods. The Journal of Molecular Diagnostics 22(11): S33, Nov 2020 Notes: Association for Molecular Pathology 2020 Annual Meeting Abstract [ID22]
Zhang Q, Orlando EJ, Wang HY, Bogusz AM, Liu X, Lacey SF, Strauser HT, Nunez-Cruz S, Nejati R, Zhang P, Brooks S, Watt CD, Melenhorst JJ, June CH, Schuster SJ, Wasik MA : Transdifferentiation of lymphoma into sarcoma associated with profound reprogramming of the epigenome. Blood 136(17): 1980-1983, Oct 2020.
Herlihy SE, Carlin A, Nasrallah NP, Watt CD and Van Deerlin VM: Evaluation of a Targeted Realtime Assay for Rapid Identification of IDH1 and IDH2 Disease-Associated Variants in Brain Tumors. The Journal of Molecular Diagnostics 21(6): 1201, Nov 2019 Notes: Association for Molecular Pathology 2019 Annual Meeting Abstract [ST059]
Garces S, Nelson N, Watt CD, and Priore S: FLT3 Variants Near Codon 835: An Institutional Experience Comparing Rapid Restriction Digest Testing with Massively Parallel Sequencing. The Journal of Molecular Diagnostics 21(6): 1230, Nov 2019 Notes: Association for Molecular Pathology 2019 Annual Meeting Abstract [TT012]
McMahon C, Ferng T, Canaani J, Wang E, Morrissette J, Eastburn D, Pellegrino M, Durruthy-Durruthy R, Watt CD, Asthana S, Lasater E, DeFilippis RA, Peretz C, McGary L, Deihimi S, Logan A, Luger S, Shah N, Carroll M, Smith C, and Perl A: Clonal selection with Ras pathway activation mediates secondary clinical resistance to selective FLT3 inhibition in acute myeloid leukemia. Cancer Discovery 9(8): 1050-1063, Aug 2019.
Brown JT, Beldorth IJ, Laosinchai-Wolf W, Fahey ME, Jefferson KL, Ruskin AK, Roth JJ, Cai L, Watt CD, Press RD, Yang F, Hedges JB, and Andruss BF: Analytical validation of a highly sensitive, multiplexed chronic myeloid leukemia monitoring system targeting BCR-ABL1 RNA. The Journal of Molecular Diagnostics 21(4): 718-733, July 2019.
McMahon CM, Canaani J, Rea B, Sargent R, Watt CD, Morrissette JJD, Carroll M, and Perl AE: Gilteritinib induces differentiation in relapsed and refractory FLT3-mutated acute myeloid leukemia. Blood Advances 3(10): 1581-1585, May 2019.
Nasrallah MP, Binder ZA, Oldridge DA, Zhao J, Lieberman DB, Roth JJ, Watt CD, Sukhadia S, Klinman E, Daber RD, Desai A, O’Rourke DM, and Morrissette JJD: Molecular neuropathology in practice: Clinical profiling and integrative analysis of molecular alterations in glioblastoma. Academic Pathology 6: 2374289519848353, May 2019 Notes: No issue.