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Tilo Grosser, M.D.

Tilo Grosser, M.D.

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Research Associate Professor of Pharmacology
Department: Pharmacology
Graduate Group Affiliations

Contact information
Department of Pharmacology / Institute for Translational
Medicine and Therapeutics
University of Pennsylvania Perleman School of Medicine
Smilow Center for Translational Research
3400 Civic Center Boulevard, Building 421
10th Floor, Room 103
Philadelphia, PA 19104-5158
Office: (215) 573-7600
Education:
M.D. (Medicine)
Heinrich-Heine University, Düsseldorf, Germany, 1996.
Dr. med. (Medical research doctorate in Cardiovascular Pharmacology)
Heinrich-Heine University, Düsseldorf, Germany, 1998.
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Description of Research Expertise

Non-steroidal anti-inflammatory drugs (NSAIDs), which include both traditional NSAIDs (e.g. naproxen, ibuprofen) and NSAIDs selective for cyclooxygenase (COX)-2 (rofecoxib, valdecoxib, etoricoxib, lumiracoxib, celecoxib) relieve pain, inflammation and fever by inhibiting the formation of bioactive prostanoids. Despite their efficacy in the relief of pain and inflammation, NSAIDs may be associated with gastrointestinal complications, including serious bleeds. Selectivity for COX-2 has been shown to reduce the incidence of these serious events, but is more likely to cause serious cardiovascular events than non-selective COX inhibition.

Dr. Grosser is studying the mechanisms of these complications using genomics, proteomics, lipidomics approaches in model organisms and in proof-of-concept studies in healthy volunteers. One aim of this research is to identify approaches to the personalization of NSAID therapy.

Selected Publications

Li X, Fries S, Li R, Lawson JA, Propert KJ, Diamond SL, Blair IA, FitzGerald GA, Grosser T: Differential impairment of aspirin-dependent platelet cyclooxygenase acetylation by nonsteroidal antiinflammatory drugs. Proc Natl Acad Sci U S A. 111(47): 16830-5, 2014 Notes: [Open Access: http://www.pnas.org/content/111/47/16830.long]

Grosser T, Fries S, Lawson JA, Kapoor SC, Grant GR, FitzGerald GA: Drug Resistance and Pseudoresistance: An Unintended Consequence of Enteric Coating Aspirin. Circulation 127(3): 377-85, 2013 Notes: [Open Access: http://circ.ahajournals.org/content/127/3/377.full]

Chen L, Yang G, Grosser T: Prostanoids and inflammatory pain. Prostaglandins Other Lipid Mediat 104-105: 58-66, 2012.

Fong KP, Barry C, Tran AN, Traxler EA, Wannemacher K, Tang H, Speicher KD, Blair IA, Speicher DW, Grosser T, Brass LF: Deciphering the human platelet sheddome. Blood 117(1): e15-26, 2011.

Grosser T, Yu Y, FitzGerald GA: Emotion recollected in tranquility: Lessons learned from the COX-2 saga. Annu Rev Med 61: 17-33, 2010.

Lucitt MB, Price TS, Pizarro A, Wu W, Yocum AK, Seiler C, Pack MA, Blair IA, FitzGerald GA, Grosser T: Analysis of the zebrafish proteome during embryonic development. Mol Cell Proteomics 7(5): 981-94, 2008 Notes: [Cover image]

Price TS, Lucitt MB, Wu W, Austin DJ, Pizarro A, Yocum AK, Blair IA, Fitzgerald GA, Grosser T: EBP: Protein identification using multiple tandem mass spectrometry datasets. Mol Cell Proteomics 6: 527-536, 2007.

Fries S*, Grosser T* [* Co-First Authors], Price TS, Lawson JA, Kapoor S, DeMarco S, Pletcher MT, Wiltshire T, FitzGerald GA: Marked interindividual variability in the response to selective inhibitors of cyclooxygenase-2. Gastroenterology 130: 55-64, 2006.

Grosser T, Fries S, FitzGerald GA: Biological basis for the cardiovascular consequences of COX-2 inhibition: Therapeutic challenges and opportunities. J Clin Invest 116: 4-15, 2006.

Grosser T, Yusuff S, Cheskis E, Pack MA, FitzGerald GA: Developmental expression of functional cyclooxygenases in zebrafish. Proc Natl Acad Sci USA 99: 8418-8423, 2002 Notes: [Editorial: Prescott SM, Yost HJ The COXes of Danio: From mechanistic model to experimental therapeutics. Proc Natl Acad Sci USA 99(14): 9084-9086, 2002]

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Last updated: 12/05/2014
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