faculty photo

Frank J. Rauscher

Wistar Institute Professor of Genetics
Department: Genetics
Graduate Group Affiliations

Contact information
Wistar Institute
3601 Spruce Street
Philadelphia, PA 19104
Office: (215) 898-0995
Fax: (215) 898-3929
Education:
BS (Biology)
Moravian College, 1979.
PhD (Pharmacology)
SUNY, Buffalo, NY, 1987.
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Selected Publications

Cable PL, Wilson CA, Calzone FJ, Rauscher FJ 3rd. Scully R, Livingston DM, Li L, Blackwell CB, Futreal PA, Afshari CA: Novel consensus DNA-binding sequence for BRCA1 protein complexes. Molecular Carcinogenesis 38(2): 85-96, October 2003.

Ayyanathan K, Lechner MS, Bell P, Maul GG, Schultz DC, Yamada Y, Tanaka K, Torigoe K, Rauscher FJ 3rd: Regulated recruitment of HP1 to a euchromatic gene induces mitotically heritable, epigenetic gene silencing: a mammalian cell culture model of gene variegation. Genes & Development 17(15): 1855-69, August 1 2003.

Peng H, Zheng L, Lee WH, Rux JJ, Rauscher FJ 3rd: A common DNA-binding site for SZF1 and the BRCA1-associated zinc finger protein, ZBRK1. Cancer Research 62(13): 3773-81, July 1 2002.

Peng H. Feldman I. Rauscher FJ 3rd: Hetero-oligomerization among the TIF family of RBCC/TRIM domain-containing nuclear cofactors: a potential mechanism for regulatin the switch between coactivation and corepression. Journal of Molecular Biological 320(3): 629-44, July 2002.

Schultz DC, Ayyanathan K, Negorev D, Maul GG, Rauscher FJ 3rd: SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins. Genes & Development 16(8): 919-32, April 15 2002.

Schultz DC, Friedman JR, Rauscher FJ 3rd: Targeting histone deacetylase complexes via KRAB-zinc finger proteins: the PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2alpha subunit of NuRD. Genes & Development 15(4): 428-43, Feb 15 2001.

Fredericks WJ, Ayyanathan K, Rauscher FJ 3rd: Regulating the neoplastic phenotype using engineered transcriptional repressors. Cancer Letters 162 Suppl: S23-S32, Jan 2001.

Scott GK, Chang CH, Erny KM, Xu F, Fredericks WJ, Rauscher FJ 3rd, Thor AD, Benz CC: Ets regulation of the erbB2 promoter. Oncogene 19(55): 6490-502, Dec 18 2000.

Ayyanathan K, Fredericks WJ, Berking C, Herlyn M, Balakrishnan C, Gunther E, Rauscher FJ 3rd: Hormone-dependent tumor regression in vivo by an inducible transcriptional repressor directed at the PAX3-FKHR oncogene. Cancer Research 60(20): 5803-14, Oct 15 2000.

Lechner MS, Begg GE, Speicher DW, Rauscher FJ 3rd.: Molecular determinants for targeting heterochromatin protein 1-mediated gene silencing: direct chromoshadow domain-KAP-1 corepressor interaction is essential. Molecular & Cellular Biology 20(17): 6449-65, September 2000.

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Last updated: 08/24/2015
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