Description of Research Expertise

Computational and systems biology
Pharmacoinformatics
Macromolecular linguistics
Data integration
Philosophy of science

Selected Publications

Searls, D.B. : Omic empiricism. Science Signaling 2(68): eg6, 2009.

Agarwal, P. and Searls, D.B. : Literature mining in support of drug discovery. Briefings in Bioinformatics 9(6): 479-492, 2008.

Chiang, D., Joshi, A.K. and Searls, D.B. : Grammatical representations of macromolecular structure. Journal of Computational Biology 13(5): 1077-1100, 2006.

Searls, D.B. : Data integration: challenges for drug discovery. Nature Reviews Drug Discovery 4(1): 45-58, 2005.

Searls, D.B. : Trees of life and of language. Nature 426(6965): 391-392, 2003.

Searls, D.B. : Data integration—connecting the dots. Nature Biotechnology 21(8): 844-845, 2003.

Searls, D.B. : Pharmacophylogenomics: genes, evolution and drug targets. Nature Reviews Drug Discovery 2(8): 613-623, 2003.

Searls, D.B. : The language of genes. Nature 420(6912): 211-217, 2002.

Searls, D.B. : From Jabberwocky to genome: Lewis Carroll and computational biology. Journal of Computational Biology 8(3): 339-348, 2001.

Searls, D.B. : Bioinformatics tools for whole genomes. Annual Review of Genomics and Human Genetics, Annual Reviews, pp. 251-279, 2000.

Searls, D.B. : Formal language theory and biological macromolecules. Mathematical Support for Molecular Biology, American Mathematical Society Press, pp. 117-140, 1999.

Searls, D.B. : Sequence alignment through pictures. Trends in Genetics 12(1): 35-37, 1996.

Searls, D.B. : String Variable Grammar: a logic grammar formalism for DNA sequences. Journal of Logic Programming 24(1,2): 73-102, 1995.

Dong, S. and Searls, D.B. : Gene structure prediction by linguistic methods. Genomics 23: 540-551, 1994.