William M. Armstead, BA, MS, PhDResearch Professor of Anesthesiology and Critical Care
Member, Institute of Neurological Sciences, University of Pennsylvania
Member, Cardiovascular Institute, University of Pennsylvania
Department: Anesthesiology and Critical Care
Contact information
Department of Anesthesiology and Critical Care
3620 Hamilton Walk, JM3 Philadelphia, PA 19104-4283
Office: 215-573-3674
Fax: 215-349-5078 Email: armsteaw@uphs.upenn.edu
Graduate Group Affiliations
Publications
Links
Search PubMed for articles Department of Anesthesiology and Critical Care Pharmacological Sciences Graduate Group Faculty
Education:
B.A. (Biochemistry) University of Pennsylvania, 1979. M.S. (Pharmacology) Tulane University, 1983. Ph.D. (Pharmacology) Tulane University, 1985.
Post-Graduate Training
Permanent linkPostdoctoral Fellow/Instructor, Department of Pharmacology , Tulane University, 1985-1986. Postdoctoral Fellow, Department of Physiology and Biophysics, University of Tennessee, Memphis, TN, 1986-1988. Description of Research ExpertiseResearch InterestsControl of cerebral hemodynamics during physiologic and pathologic conditions such as traumatic brain injury, stroke, and cerebral ischemia/reperfusion. Research Techniques Closed cranial window for measurement of pial artery diameter and collection of cortical periarachnoid CSF for vasoactive metabolite concentration determination by RIA, fluid percussion brain injury, global cerebral ischemia, photothrombotic cerebral injury, radiolabelled microsphere regional cerebral blood flow determination. Research Summary Dr. Armstead's research focuses on characterizing mechanisms important in the control of cerebral hemodynamics under physiologic and pathologic conditions such as traumatic brain injury (TBI), stroke, and cerebral hypoxia/ischemia, particularly in the newborn. Current projects focus on interactions between the NMDA receptor and plasminogen activators after TBI, optimizing the efficacy/toxicity ratio of tPA, the only FDA approved treatment for stroke and translational research concerning the roles of sex and age in outcome after pediatric TBI. Key Words tPA, adrenomedullin, newborn, brain injury, stroke, endothelin, nitric oxide, cerebral circulation Selected PublicationsArmstead WM, Kiessling JW, Riley J, Kofke WA, Vavilala MS. : Phenylephrine infusion prevents impairment of ATP and Calcium sensitive K channel mediated cerebrovasodilation after brain injury in female but aggravates impairment in male piglets through modulation of ERK MAPK upregulation. J Neurotrauma 28: 105-111, 2011.Armstead WM, Kiessling JW, Cines DB, Higazi AAR.: Glucagon protects against impaired NMDA-mediated cerebrovasodilation and cerebral autoregulation during hypotension after brain injury by activating cAMP protein kinase A anad inhibiting upregulation of tPA. J Neurotrauma 28: 451-457, 2011. Armstead WM, Riley J, Cines DB, Higazi AAR. : tPA contributes to impairment of ATP and calcium sensitive K channel mediated cerebrovasodilation afer hypoxia/ischemia through upregulation of ERK MAPK. Brain Res 1376: 88-93, 2011. Siriussawakul A, Sharma D, Sookplung P, Armstead WM, Vavilala MS.: Gender differences in cerebrovascular reactivity to carbon dioxide during sevoflurane anesthesia in children: preliminary findings. Pediatric Anesthesia 21: 141-147, 2011. Diansan Su, Riley, John, Kiessling, Willis J, Armstead, William M, Liu Renyu : Salvinorin A produces cerebrovasodilation through activation of nitric oxide synthase, κ receptor, and adenosine triphosphate-sensitive potassium channel. Anesthesiology, 114: 374-379, 2011 Anesthesiology 114: 374-379, 2011. Armstead WM, Raghupathi R: Endothelin and the neurovascular unit in pediatric traumatic brain injury. Neurological Research 33: 127-132, 2011. Kreipke CW, Rafols JA, Reynolds CA, Schafer S, Marinica A, Beford C, Fronczak M, Kuhn D, Armstead WM: Clazosentan a novel endothelin-A antagonist improves CBF and behavior after TBI. Neurological Research 33: 208-213, 2011. Armstead WM, Kreipke CW.: Endothelin-1 is upregulated after traumatic brain injury: A cross-species, cross-model analysis. Neurological Research 33: 133-136, 2011. DiGennaro JL, Mack CD, Malakouti A, Zimmerman JJ, Chesnut R, Armstead W, Vavilala MS: Use and effect of vasopressors after pediatric traumatic brain injury. Developmental Neuroscience 32: 420-430, 2011. Armstead WM, Riley J, Kiessling JW, Cines DB, Higazi AAR: Novel plasminogen activator inhibitor -1 derived peptide protects against impairment of cerebrovasodilation after photo thrombosis through inhibition of JNK MAPK. Am J Physiol 299: R480-R485, 2010.
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