Issam A. Mardini, MD, PhDAssistant Professor of Clinical Anesthesiology and Critical Care
Attending Physician, Hospital of the University of Pennsylvania
Attending Physician, Penn Presbyterian Medical Center
Department: Anesthesiology and Critical Care
Contact information
Department of Anesthesiology and Critical Care
University of Pennsylvania Health System Penn Tower 1106 3400 Spruce Street Philadelphia, PA 19104
Office: (610) 416-4145
Fax: (215) 893-7267 Email:
issam.mardini@uphs.upenn.edu
Education:
M.D. University of Damascus, Damascus, Syria, 1978. Ph.D. (Physiology & Pharmacology) University of South Dakota, 1985.
Post-Graduate Training
Resident, Surgery, University of Damascus Hospitals, Damascus, Syria, 1979-1979. Research Associate, Physiology, Kuwait University, Kuwait, 1979-1981. Graduate Student/ Research Assistant, Physiology & Pharmacology, Univ. of SD, Vermillion, SD, 1981-1985. Resident (PGY-1), Department of Internal Medicine, Temple University Hospital, Philadelphia, PA, 1993-1994. Resident, Department of Anesthesiology, Temple University Hospital, Philadelphia, PA, 1994-1997. Fellow, Research and Pain Management, Department of Anesthesia & Center for Exp. Therapeutics, University of Pennsylvania, Philadelphia, PA, 1997-1999.
Certifications
Permanent linkECFMG # 296-797-4, 1982. Diplomate, American Board of Anesthesiology # 31951, 1999. ABA, Subspeciality of Pain Management, Certified, 2000. ABA, Pain Medicine, Re-certified, to 2020, 2009. American Board of Anesthesiology, Voluntary Recertification, 2009. American Board of Anesthesiology, Hospice & Palliative Medicine certification, 2012. Description of Research ExpertiseAnti-inflammatory drugs, cyclooxygenases ,prostaglandins, mechanisms of painDescription of Clinical ExpertiseAcute pain management, perioperative pain control, chronic pain medicine, nerve blocks and regional anesthesia, injection/ablation for chronic pain, anesthesia for orthopedic and gynecological surgery, anesthesia for head and neck surgery, anesthesia for urological surgeryDescription of Other ExpertiseEducational development for professional students and graduate/postgraduate physiciansSelected PublicationsOchroch AE, Mardini IA, Gottschlak A: What is the role of NSAIDs in pre-emptive analgesia drugs. Current Opinion 63 (4): 2709-2723, 2003.Akosy MO, Mardini IA, Yang Y, Bin W, Zhou S, Kelsen SF: Glucocorticoid effects on the beta-adrenergic receptor-adenylyl cyclase system on human airway epithelium. J Allergy Clin Immunol 109 (3): 491-497, 2003. Barnett RE, Fish D, Katragadda R, Mardini IA, O'Grady TJ: A preemptice approach to stop postoperative pain. A symposium. Contemporary Surgery 59 (12): 559-566, 2003. Ferrante FM, King LF, Roche EA, Kim PS, Aranda M, Delaney LD, Mardini IA, Mannes AJ: Radiofrequency Sacroiliac Joint Denervation for Sacroiliac Syndrome. Regional Anesthesia and Pain Medicine 26: 137-142, 2001. Mardini IA, FitzGerald GA: Selective inhibitors of cyclooxyegenase-2: A growing class of anti-inflammatory drugs. Molecular Interventions 1: 30-38, 2001. McAdam BF, Mardini IA, Burke A, Habib A, Lawson JA, Kapoor S, FitzGerald GA: Effect of regulated expression of human cyclooxygenase isoforms on eicosanoid and isoeicosanoid production in inflammation. J Clin Invest 105 (10): 1473-1482, 2000. McAdam BF, Catella-Lawson F, Mardini IA, Kapoor S, Lawson J, FitzGerald GA: Systemic biosynthesis of prostacyclin by cyclooxygenase (COX-2): The human pharmacology of a selective inhibitor of COX-2. Proc Natl Acad Sci USA 96: 272-277, 1999. Mardini IA, Lawson JA, FitzGerald GA: Cyclooxygenase activation is a minor contributor to lipid peroxidation induced by endotoxin (LPS) adminstration in humans. Circulation 100(18) 100 (18): I-412, November 1999 Notes: Presented at the American Heart Association Meeting, Atlanta, GA. Mardini IA, Lawson JA, Rokach JA, Adiyaman M, Hwang S, Khanapure SP, Schumacher KJ, FitzGerald GA: A newly-discovered isoprostane is a marker of oxidative stress in LPS-mediated inflammation in humans. Circulation 98(17): I-7, October 1998 Notes: Presented at the American Heart Association Meeting, Dallas, TX. Kelsen SG, Higgins NC, Zhou S, Mardini IA, Benovic JL: Expression and function of the beta-adrenergic receptor coupled-adenylyl cyclase system on human airway epithelial cells. Am J Respir & Crit Care Med 152(6 pt 1): 1774-1783, 1995.
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