Department of Anesthesiology and Critical Care

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Issam A. Mardini, MD, PhD

Assistant Professor of Clinical Anesthesiology and Critical Care
Attending Physician, Hospital of the University of Pennsylvania
Attending Physician, Penn Presbyterian Medical Center
Department: Anesthesiology and Critical Care

Contact information
Department of Anesthesiology and Critical Care
University of Pennsylvania Health System
Penn Tower 1106
3400 Spruce Street
Philadelphia, PA 19104
Office: (610) 416-4145
Fax: (215) 893-7267
University of Damascus, Damascus, Syria, 1978.
Ph.D. (Physiology & Pharmacology)
University of South Dakota, 1985.
Post-Graduate Training
Resident, Surgery, University of Damascus Hospitals, Damascus, Syria, 1979-1979.
Research Associate, Physiology, Kuwait University, Kuwait, 1979-1981.
Graduate Student/ Research Assistant, Physiology & Pharmacology, Univ. of SD, Vermillion, SD, 1981-1985.
Resident (PGY-1), Department of Internal Medicine, Temple University Hospital, Philadelphia, PA, 1993-1994.
Resident, Department of Anesthesiology, Temple University Hospital, Philadelphia, PA, 1994-1997.
Fellow, Research and Pain Management, Department of Anesthesia & Center for Exp. Therapeutics, University of Pennsylvania, Philadelphia, PA, 1997-1999.
ECFMG # 296-797-4, 1982.
Diplomate, American Board of Anesthesiology # 31951, 1999.
ABA, Subspeciality of Pain Management, Certified, 2000.
ABA, Pain Medicine, Re-certified, to 2020, 2009.
American Board of Anesthesiology, Voluntary Recertification, 2009.
American Board of Anesthesiology, Hospice & Palliative Medicine certification, 2012.
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Description of Research Expertise

Anti-inflammatory drugs, cyclooxygenases ,prostaglandins, mechanisms of pain

Description of Clinical Expertise

Acute pain management, perioperative pain control, chronic pain medicine, nerve blocks and regional anesthesia, injection/ablation for chronic pain, anesthesia for orthopedic and gynecological surgery, anesthesia for head and neck surgery, anesthesia for urological surgery, anticoagulation agents in the perioperative period and their interactions with regional anesthesia.

Description of Other Expertise

Educational development for professional students and graduate/postgraduate physicians

Selected Publications

Ochroch AE, Mardini IA, Gottschlak A: What is the role of NSAIDs in pre-emptive analgesia drugs. Current Opinion 63 (4): 2709-2723, 2003.

Akosy MO, Mardini IA, Yang Y, Bin W, Zhou S, Kelsen SF: Glucocorticoid effects on the beta-adrenergic receptor-adenylyl cyclase system on human airway epithelium. J Allergy Clin Immunol 109 (3): 491-497, 2003.

Barnett RE, Fish D, Katragadda R, Mardini IA, O'Grady TJ: A preemptice approach to stop postoperative pain. A symposium. Contemporary Surgery 59 (12): 559-566, 2003.

Ferrante FM, King LF, Roche EA, Kim PS, Aranda M, Delaney LD, Mardini IA, Mannes AJ: Radiofrequency Sacroiliac Joint Denervation for Sacroiliac Syndrome. Regional Anesthesia and Pain Medicine 26: 137-142, 2001.

Mardini IA, FitzGerald GA: Selective inhibitors of cyclooxyegenase-2: A growing class of anti-inflammatory drugs. Molecular Interventions 1: 30-38, 2001.

McAdam BF, Mardini IA, Burke A, Habib A, Lawson JA, Kapoor S, FitzGerald GA: Effect of regulated expression of human cyclooxygenase isoforms on eicosanoid and isoeicosanoid production in inflammation. J Clin Invest 105 (10): 1473-1482, 2000.

McAdam BF, Catella-Lawson F, Mardini IA, Kapoor S, Lawson J, FitzGerald GA: Systemic biosynthesis of prostacyclin by cyclooxygenase (COX-2): The human pharmacology of a selective inhibitor of COX-2. Proc Natl Acad Sci USA 96: 272-277, 1999.

Mardini IA, Lawson JA, FitzGerald GA: Cyclooxygenase activation is a minor contributor to lipid peroxidation induced by endotoxin (LPS) adminstration in humans. Circulation 100(18) 100 (18): I-412, November 1999 Notes: Presented at the American Heart Association Meeting, Atlanta, GA.

Mardini IA, Lawson JA, Rokach JA, Adiyaman M, Hwang S, Khanapure SP, Schumacher KJ, FitzGerald GA: A newly-discovered isoprostane is a marker of oxidative stress in LPS-mediated inflammation in humans. Circulation 98(17): I-7, October 1998 Notes: Presented at the American Heart Association Meeting, Dallas, TX.

Kelsen SG, Higgins NC, Zhou S, Mardini IA, Benovic JL: Expression and function of the beta-adrenergic receptor coupled-adenylyl cyclase system on human airway epithelial cells. Am J Respir & Crit Care Med 152(6 pt 1): 1774-1783, 1995.

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Last updated: 04/03/2014
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