Department of Anesthesiology and Critical Care

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Issam A. Mardini, MD, PhD

Assistant Professor of Clinical Anesthesiology and Critical Care
Attending Physician, Hospital of the University of Pennsylvania
Attending Physician, Penn Presbyterian Medical Center
Department: Anesthesiology and Critical Care

Contact information
Department of Anesthesiology and Critical Care
3400 Spruce Street
Philadelphia, PA 19104
Office: (610) 416-4145
University of Damascus, Damascus, Syria, 1978.
Ph.D. (Physiology & Pharmacology)
University of South Dakota, 1985.
Post-Graduate Training
Resident, Surgery, University of Damascus Hospitals, Damascus, Syria, 1979-1979.
Research Associate, Physiology, Kuwait University, Kuwait, 1979-1981.
Graduate Student/ Research Assistant, Physiology & Pharmacology, Univ. of SD, Vermillion, SD, 1981-1985.
Resident (PGY-1), Department of Internal Medicine, Temple University Hospital, Philadelphia, PA, 1993-1994.
Resident, Department of Anesthesiology, Temple University Hospital, Philadelphia, PA, 1994-1997.
Fellow, Research and Pain Management, Department of Anesthesia & Center for Exp. Therapeutics, University of Pennsylvania, Philadelphia, PA, 1997-1999.
ECFMG # 296-797-4, 1982.
Diplomate, American Board of Anesthesiology # 31951, 1999.
ABA, Subspeciality of Pain Management, Certified, 2000.
American Board of Anesthesiology, Voluntary Recertification, 2009.
ABA, Pain Medicine, Re-certified, to 2020, 2009.
American Board of Anesthesiology, Hospice & Palliative Medicine Certification, 2012.
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Description of Research Expertise

Anti-inflammatory drugs, cyclooxygenases ,prostaglandins, mechanisms of pain

Description of Clinical Expertise

Acute pain management, perioperative pain control, chronic pain medicine, nerve blocks and regional anesthesia, injection/ablation for chronic pain, anesthesia for orthopedic and gynecological surgery,anesthesia for urological surgery, anticoagulation agents in the perioperative period and their interactions with regional anesthesia.

Description of Other Expertise

Educational development for professional students and graduate/postgraduate physicians

Selected Publications

Barnett RE, Fish D, Katragadda R, Mardini IA, O'Grady TJ: A preemptice approach to stop postoperative pain. A symposium. Contemporary Surgery 59 (12): 559-566, 2003.

Aksoy Mark O, Mardini Issam A, Yang Yi, Bin Wei, Zhou Shuangwen, Kelsen Steven G: Glucocorticoid effects on the beta-adrenergic receptor-adenylyl cyclase system of human airway epithelium. The Journal of allergy and clinical immunology 109(3): 491-7, Mar 2002.

McAdam B F, Mardini I A, Habib A, Burke A, Lawson J A, Kapoor S, FitzGerald G A: Effect of regulated expression of human cyclooxygenase isoforms on eicosanoid and isoeicosanoid production in inflammation. The Journal of clinical investigation 105(10): 1473-82, May 2000.

McAdam B F, Catella-Lawson F, Mardini I A, Kapoor S, Lawson J A, FitzGerald G A: Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: the human pharmacology of a selective inhibitor of COX-2. Proceedings of the National Academy of Sciences of the United States of America 96(1): 272-7, Jan 1999.

Kelsen S G, Higgins N C, Zhou S, Mardini I A, Benovic J L: Expression and function of the beta-adrenergic receptor coupled-adenylyl cyclase system on human airway epithelial cells. American journal of respiratory and critical care medicine 152(6 Pt 1): 1774-83, Dec 1995.

Kelsen S G, Zhou S, Anakwe O, Mardini I, Higgins N, Benovic J L: Expression of the beta-adrenergic receptor-adenylylcyclase system in basal and columnar airway epithelial cells. The American journal of physiology 267(4 Pt 1): L456-63, Oct 1994.

Mardini I A, Higgins N C, Zhou S, Benovic J L, Kelsen S G: Functional behavior of the beta-adrenergic receptor-adenylyl cyclase system in rabbit airway epithelium. American journal of respiratory cell and molecular biology 11(3): 287-95, Sep 1994.

Kelsen S G, Sexauer W P, Mardini I A, Criner G J: The comparative effects of elastase-induced emphysema on costal and crural diaphragm and parasternal intercostal muscle contractility. American journal of respiratory and critical care medicine 149(1): 168-73, Jan 1994.

Kelsen S G, Bao S, Thomas A J, Mardini I A, Criner G J: Structure of parasternal intercostal muscles in the adult hamster: topographic effects. Journal of applied physiology (Bethesda, Md. : 1985) 75(3): 1150-4, Sep 1993.

Kelsen S G, Mardini I A, Zhou S, Benovic J L, Higgins N C: A technique to harvest viable tracheobronchial epithelial cells from living human donors. American journal of respiratory cell and molecular biology 7(1): 66-72, Jul 1992.

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Last updated: 05/09/2017
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