Renyu Liu, M.D., M.S., Ph.D.Assistant Professor of Anesthesiology and Critical Care at the Hospital of the University of Pennsylvania
Attending Anesthesiologist
Instructor in Anesthesiology and Critical Care
Co-Director
Department: Anesthesiology and Critical Care
Contact information
Department of Anesthesiology and Critical Care
336 John Morgan Building 3620 Hamilton Walk Philadelphia, PA 19104
Office: 2156623750
Fax: 2153495078 Email: liur@uphs.upenn.edu
Publications
Education:
M.D. (Medicine) Xuzhou Medical College, China, 1990. MS Jiaotong University School of Medicine, China, 1993. Ph.D. Tottori University School of Medicine, Japan, 2000.
Post-Graduate Training
Resident in Anesthesiology, Renji Hospital, Shanghai Second Medical University, Shanghai, China, 1993-1995. Postdoctoral Research Fellow, University of Pennsylvania, Philadelphia, PA, 2001-2004. Intern in Medicine, Mercy Fitzgerald Hospital/Mercy Hospital of Philadelphia, PA, 2004-2005. Resident in Anesthesiology and Critical Care, Hospital of the University of Pennsylvania, Philadelphia, PA, 2005-2008.
Certifications
Permanent linkAmerican Board of Anesthesiology Eligible, 2008. Description of Research ExpertiseMy lab's major interest is to investigate the molecular recognition mechanism of opioids and their receptors using biophysical, biochemical, thermodynamic, protein engineering, and high-resolution structural approaches. I also collaborate closely with Dr. Eckenhoff in investigating interactions of general anesthetics with proteins.Description of Clinical ExpertiseAnesthesia for general surgery patientsPerioperative Medicine outside OR anesthesia services optimal opioid usage in perioperative period Selected PublicationsZhou R, Meng Q, Xie F, Eckenhoff RG, Liu R: Characterization of direct binding of opioids to human serum albumin. Anesthesiology 2009 Notes: In Press.Liu R, Xi J, Eckenhoff R: Using Autodock to predict binding constant and locate binding sites for general anesthetics Anesthesiology 2009 Notes: In Press. Aguilar JMP, Saven JG, Liu R: Novel structural model of human mu-receptor and its binding with opioid agonists and antagonist. Anesthesiology 2009 Notes: In Press. Xi J, Liu R, Rossi MJ, Yang J, Loll PJ, Dailey WP, Eckenhoff RG: Photoactive analogues of the haloether anesthetics provide high-resolution features from low-affinity interactions. ACS Chem Biol 1(6): 377-84, 2006. West J, Xi J, Liu R, Dmochowski I, Eckenhoff R: Volatile Anesthetics Reduce Iron Uptake by Apoferritin. Anesthesiology 2005 Liu R, Eckenhoff RG: Weak Polar Interactions Confer Binding Site Selectivity for Haloether Anesthetics. Anesthesiology 102(4): 799-805, 2005. Liu R, Eckenhoff RG: Weak polar interactions confer albumin binding site selectivity for haloether anesthetics. Anesthesiology 102(4): 799-805, 2005. Liu R, Yang J, Ha CE, Bhagavan NV, Eckenhoff RG: Truncated human serum albumin retains general anaesthetic binding activity. Biochem J 388(Pt 1): 39-45, 2005. Liu R, Loll PJ, Eckenhoff RG: Structural basis for high-affinity volatile anesthetic binding in a natural 4-helix bundle protein. Faseb J 19(6): 567-76, 2005. Liu R, Eckenhoff RG: Interaction between anesthetic molecules and their binding sites must be far more complex. Anesthesiology 103: 1102, 2005.
|
