Sheryl G. Beck, BS, MS, PhDResearch Associate Professor of Anesthesiology and Critical Care
Associate member of Children's Hospital of Philadelphia Research Institute, The Children’s Hospital of Philadelphia
Department: Anesthesiology and Critical Care
Contact information
Anesthesiology and Critical Care
4 North ARC, Room 402C Children's Hospital of Philadelphia Research Institute 3615 Civic Center Boulevard Philadelphia, PA 19104-4318
Office: 215-590-0651
Fax: 215-590-4107 Email: becks@email.chop.edu
Graduate Group Affiliations
Links
Biomedical Graduate Studies, Neuroscience Graduate group Division of Stress Neurobiology Pharmacology
Education:
B.S. (Psychology) University of Washington , 1973. M.S. (Psychology) Western Washington State University , 1977. Ph.D. (Major: Medical Psychology, Minor: Biochemistry) Oregon Health Sciences University , 1981.
Post-Graduate Training
Permanent linkPharmacology, Mount Sinai School of Medicine , New York, NY , 1981-1983. Description of Research ExpertiseThe overall goal my laboratory is to elucidate how substrates of the stress response are involved in medical or psychiatric disorders. Specific areas of interest include interactions between GABAergic, corticotropin-releasing factor-like peptide and monoamine systems; the impact of long term stress and glucocorticoids on neuronal function; developmental regulation of the 5-HT limbic system; circuitry linking stress substrates to monoamine systems; stress substrates as targets of psychotherapeutic agents. We have determined, for example, that the basic cellular characteristics, morphology, cell number and excitatory and inhibitory synaptic input to 5-HT neurons within the different subfields of the dorsal and median raphe are different, and they are selectively modulated in genetically engineered mice that have an anxious phenotype or in animal models that have been subjected to stress protocols. In addition, the circuitry of the CA1 subfield of the hippocampus has been selectively altered. Approaches include whole cell electrophysiology, in vitro and in vivo single unit electrophysiology, immunohistochemistry, neuroanatomy, cellular morphology, behavior, use of genetically manipulated mouse models of mood disorders and collaborations with geneticists and molecular biologists.Selected PublicationsCalizo LH, Akanwa A, Ma X, Pan YZ, Lemos JC, Craige C, Heemstra LA, Beck SG.: Raphe serotonin neurons are not homogenous: Electrophysiological, morphological and neurochemical evidence. Neuropharmacology 61(3): 524-43, April 2011.Lemos J.C., Zhang G., Walsh T., Kirby L.G., Akanwa A., Brooks-Kayal A., Beck S.G.: Stress-Hyperresponsive WKY Rats Demonstrate Depressed Dorsal Raphe Neuronal Excitability and Dysregulated CRF-Mediated Responses. Neuropsychopharmacology 36(4): 721-724, March 2011. Bingham, B., McFadden K., Zhang X., Bhatnagar S., Beck S.G., Valentino R.J. : Early adolescence as a critical window during which social stress distinctly alters behavior and brain norepinephrine activity. Neuropsychopharmacology 36(4): 896-909, Mar 2011. Freeman-Daniels E Beck SG Kirby LK: Cellular correlates of anxiety in CA1 hippocampal pyramidal cells of 5-HT1A receptor knockout mice. Psychopharmacology 213(2-3): 453-63, Feb 2011. Yadav P.N., Abbas A.I., Farrell M.S., Setola V., Sciaky N., Huang X., Kroeze W.K., Crawford L.K., Piel D.A., Keiser M.J., Irwin J.J., Shoichet B.K., Deneris E.S., Gingrich J., Beck S.G., Roth B.L.: The Presynaptic Component of the Serotonergic System is Required for Clozapine's Efficacy. Neuropsychopharmacology 36(3): 638-51, Feb 2011. Richardson-Jones, J., Craige, C., Nguyen, T., Kung, H.F., Gardier, A., Dranovsky, A., David, D.J., Guiard, B., Beck, S.G., Hen, R., Leonardo, E.D.: Serotonin-1A autoreceptors are necessary and sufficient for the normal formation of circuits underlying innate anxiety. Journal of Neuroscience 61(3): 524-543, 2011. Lamy, C. and Beck, S.G.: Swim stress differentially blocks CRF receptor mediated responses in dorsal raphe nuleus Psychoneuroendocrinology 35(9): 1321-1332, October 2010. Crawford, L.K., Craige, C.and Beck, S.G. : Increased intrinsic excitability of lateral wing 5-HT neurons of the dorsal raphe: a mechanism for selective neuronal activation in stress circuits. Journal of Neurophysiology 103(5): 2652-63, May 2010. Richardson-Jones, J.W., Craige, C.P., Guiard, B.P., Stephen, A., Metzger, K.L., Kung, H.F., Gardier, A.M., Dranovsky, A., David, D.J., Beck, S.G., Hen, R., Leonardo, E.D.: 5-HT1A autoreceptor levels determine vulnerability to stress and response to antidepressants. Neuron 65(1): 40-52, January 2010. Swinny,J.D., O’Farrell, E., Bingham, B.D., Piel, D.A., Valentino, R.J. and Beck, S. G.: Neonatal rearing conditions distinctly shape locus coeruleus neuronal activity, dendritic arborization, and sensitivity to corticotrophin-releasing factor. Int. J. of Neuropsychopharmacology 5: 1-11, August 2009.
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