James G. Hecker, PhD, MDAssistant Professor of Anesthesiology and Critical Care at the Hospital of the University of Pennsylvania
Department: Anesthesiology and Critical Care
Contact information
305 Morgan
3620 Hamilton Walk Department of Anesthesia Philadelphia, PA 19104-6112
Office: 215 349 5343
Fax: 215 349 5078 Email: heckerj@uphs.upenn.edu
Education:
University of Karlsruhe, West Germany, 1973. BS (Chemical Engineering) University of Wisconsin, 1975. MS (Chemical Engineering) University of Wisconsin, 1977. PhD (Chemical/Biomedical Engr) University of Washington, 1982. M.D. University of Virginia, Charlottesville, Virginia, 1989.
Post-Graduate Training
Transitional Internship, Virginia Mason Hospital, Seattle, 1989-1990. Resident in Anesthesiology, Hospital of the University of Pennsylvania, Philadelphia, 1990-1992. Fellowship, Molecular Biology, NIH Research Training Grant, Hospital of the University of Pennsylvania, Philadelphia, 1993-1994. NRSA Postdoctoral Fellow, Department of Anesthesia, University of Pennsylvania School of Medicine, 1993-1995.
Certifications
Permanent linkAmerican Board of Anesthesiology, 1994. Description of Research Expertisenon-viral gene delivery, transient gene expression, cationic lipid medicated gene delivery, delivery to brain/CNS, delivery to spinal cord, neuroprotection, preoperative, heat shock proteins, stroke, traumatic brain injury, traumatic spinal cord injury, molecular biology, neurosciences, cloningDescription of Clinical ExpertiseneuroanesthesiaSelected PublicationsHecker JG, Laslet L, Campbell E: Catastrophic cardiovascular collapse during carotid endarterectomy. Journal of Cardiothoracic and Vascular Anesthesia 20(2): 937-50, Nov 2005.Anderson D, Hall LL, Ayyalapu AR, Hecker JG: Stability of mRNA/cationic lipid lipoplexes in human and rat cerebrospinal fluid: methods and evidence for non-viral mRNA gene delivery to the central nervous system. Human Gene Therapy 14(3): 191-202, 2003. Niedzinski EJ, Fujii SK, Lizarzaburu ME, Hecker JG, Nantz MH: A versatile linker for non-toxic polyamine-mediated DNA transfection. Molecular Therapy 6(2): 279-286, 2002. Hecker JG: Clinical applications: When is short term expression better? 5th Annual National Meeting of the American Society of Gene Therapy, Boston, MA June 2002. Hall LL, Massey D, Hecker JG: Comparative analysis of cationic lipid-mediated RNA and DNA gene delivery in non-proliferating cells. 5th Annual National Meeting of the American Society of Gene Therapy, Boston, MA June 2002. Hecker JG, Hall LL, Irion VR: Nonviral gene delivery to the lateral ventricles in rat brain: initial evidence for widespread distribution and expression in the central nervous system. Molecular Therapy 3(3): 375-384, 2001. Hecker JG, Hall LL, Irion VR: Widespread distribution, uptake and expression in rat brain after non-viral delivery of mRNA and DNA to the lateral ventricle. Molecular Therapy 3(5 pt 2): 875, May-June 2001 Notes: 4th Annual National Meeting of the American Society of Gene Therapy, Seattle, WA. Fujii SK, Nantz MH, Hecker JG: A comparison of mRNA transfection efficacy and cytotoxicity of five lipofectins in five mammalian cell lines. Molecular Therapy 3(5 pt 2): 582, 2001 Notes: 4th Annual National Meeting of the American Society for Gene Therapy, Seattle, WA, May-June 2001. Niedzinski EJ, Lizarzaburu ME, Fujii SK, Hecker JG, Nantz MH: Structural effects of pentaerythritol polyamines on transfection efficiency and cytotoxicity. Molecular Therapy 3(5 pt 2): 591, 2001 Notes: 4th Annual National Meeting of the American Society for Gene Therapy, Seattle, WA, May-June 2001. Hecker JG, Hall LL, Irion VR: Widespread expression after non-viral mRNA and DNA gene delivery to rat brain: a model for transient, peri-operative gene expression. Anesthesiology 95: A315, 2001 Notes: American Society of Anesthesiologists National Meeting, New Orleans, LA, October 2001.
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