Raymond Stephen Roginski, MD, PhDClinical Assistant Professor of Anesthesiology and Critical Care
Department: Anesthesiology and Critical Care
Contact information
Department of Anesthesiology and Critical Care
Philadelphia Veterans Administration Medical Center 38th Street and Woodland Avenue Philadelphia, PA 19104
Education:
BS (Molecular Biophysics and Biochemistry) Yale University, 1977. MS (Cell Biology Department) Sue Golding Graduate Division, Albert Einstein College ofMedicine of Yeshiva University, 1981. PhD (Cell Biology Department) Sue Golding Graduate Division, Albert Einstein College of Medicine of Yeshiva University, 1985. MD (Medicine) Albert Einstein College of Medicine, 1985.
Post-Graduate Training
Rotating Internship, Albert Einstein Affiliated Hospitals, Bronx, NY, 1985-1986. Resident in Anesthesiology, Albert Einstein Affiliated Hospitals, Bronx, NY, 1986-1989.
Certifications
Permanent linkAmerican Board of Anesthesiology, 1992. Description of Research ExpertiseResearch on NMDA receptors and GRINL1A interactions has really come to fruition over the past year. Many roles of GRINL1A proteins are now known, e.g., RNA polymerase II subunit. Links to many neuro-psychiatric diseases have been discovered as a result of my lab's yeast two-hybrid screens that revealed 28 genes that interact with the C- and N-terminal segments of the GRINL1A Gcom1 protein. Therefore, GRINL1A is no longer an isolated, "esoteric" gene; the Y2H studies have firmly connected it to glutamatergic neurotransmission and transcription and thereby mainstreamed it. Collaborations continue and are flourishing, especially: W. A. Kofke, Deborah J. Watson (Neurosurgery), Chang-Gyu Hahn (Psychiatry) and David R. Lynch (Neurology).Distinction: Earlier in my career I co-authored papers in Cell, Molecular and Cellular Biology and Proceedings of the National Academy of Sciences of the USA with Oliver Smithies (and others). In October 2007, Dr. Smithies (and two other scientists) received the Nobel Prize in Physiology or Medicine for his discovery of principles for introducing specific gene modifications into mice using embryonic stem cells. My Education activities this year added Simulation. I took the Wiser programming course to leqarn how to devise and run scenarios and became part of Dept Sim group. I have done several Sim session with Residents. Academic: manuscript on the Gcom1-NR1 interaction and inhibition of NMDA toxicity in rat primary cortical neuronal cultures was accepted and has been epubbed (9 October 2008) in NeuroReport. Selected PublicationsRoginski RS, Mohan Raj BK, Sundeep M, Yang J: GRINL1A proteins interact with an NMDA receptor subunit in transfected cells raising the question of in vivo interaction. Society of Neuroanesthesia and Critical Care 2002 Annual Meeting abstract/J Neurosurg Anesthesiol 2002.Roginski RS, Mohan Raj BK, Birditt B, Rowen L: Hippocampal expression of a human GRINL1A complex transcription unit (CTU) splice variant suggests a role in neuroprotection. American Society of Anesthesiologists 2002 Annual Meeting abstract 2002. Roginski RS, Mohan Raj BK, Sundeep M, Yang J: Expression of a GRINL1A protein in the presence of an NMDA receptor subunit in transfected cells reveals co-localization in the plasma membrane and raises the question of a possible in vivo interaction. American Society of Anesthesiologists 2002 Annual Meeting abstract 2002. Roginski RS, Mohan Raj BK, Finkernagel SW, Sciorra LJ: Assignment of an ionotropic glutamate receptor-like gene (GRINL1A) to human chromosome 15q22.1 by in situ hybridization. Cytogenetics and Cell Genetics 93: 143-144, 2001. Mohan Raj BK, Roginski RS, Finkernagel SW, Sciorra LJ: Assignment of GRINL1B, a glutamate receptor-like processed gene, to human chromosome 4q12 by in situ hybridization. Cytogenetics and Cell Genetics 95: 238-239, 2001. Wydner KS, Mohan Raj BK, Sciorra, LJ, Roginski RS: The mouse orthologue of the human ionotropic glutamate receptor-like gene (GRINL1A) maps to mouse chromosome 9. Cytogenetics and Cell Genetics 95: 240-241, 2001. Mohan Raj BK, Roginski RS, Finkernagel SW, Sciorra LJ: Hippocampal expression of human GRINL1A, a new glutamate receptor-like gene. J Neurosurg Anesthesiol 13(4): 363 #31, 2001. Roginski RS, Mohan Raj BK: Protein expression and exon mining of GRINL1A, a new glutamate receptor-like gene expressed in the human hippocampus. Anesthesiology 95: A777, 2001. El-Maghrabi EA, Roginski RS, Elnabawi AM, Eldefrawi M, Eckenhoff RG: Effect of volatile anesthetics on glutamate transport. Gordon Research Conference: “Membrane transport proteins.” New London, CT July 2000. Mohan Raj BK, Roginski RS, Finkernagel SW, Sciorra LJ: Chromosome mapping of a new glutamate receptor gene suggests roles in neuroprotection and autism. J Neurosurg Anesthesiol 12(4): 414 #54, 2000.
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