Department of Anesthesiology and Critical Care

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Raymond Stephen Roginski, MD, PhD

Clinical Assistant Professor of Anesthesiology and Critical Care
Department: Anesthesiology and Critical Care

Contact information
Department of Anesthesiology and Critical Care
Philadelphia Veterans Administration Medical Center
3900 Woodland Avenue
Philadelphia, PA 19104
Office: 215-823-5800 x5418
Fax: 215-823-4171
Lab: 215-823-5800 x3970
Education:
BS (Molecular Biophysics and Biochemistry)
Yale University, 1977.
MS (Cell Biology Department)
Sue Golding Graduate Division, Albert Einstein College of Medicine of Yeshiva University, 1981.
MD (Medicine)
Albert Einstein College of Medicine, 1985.
PhD (Cell Biology Department)
Sue Golding Graduate Division, Albert Einstein College of Medicine of Yeshiva University, 1985.
Post-Graduate Training
Rotating Internship, Albert Einstein Affiliated Hospitals, Bronx, NY, 1985-1986.
Resident in Anesthesiology, Albert Einstein Affiliated Hospitals, Bronx, NY, 1986-1989.
Certifications
American Board of Anesthesiology, 1992.
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Description of Research Expertise

Research on NMDA receptors and GRINL1A interactions has really come to fruition over the past year. My lab and others around the world have found disease-related roles of GRINL1A (now a.k.a. GCOM1) and GRINL1B (GCOM2) genes and proteins, e.g., the Gdown1 protein has been identified as 13th RNA polymerase II subunit; Gup1 is a.k.a. Myozap, a component of the cardiac muscle intercalated disk with a role in a form of cardiomyopathy; the GRINL1B gene was shown to be mutated in acute myeloid leukemia and many other reports such that the total bibliography now exceeds 20 peer reviewed articles. Links to many neuro-psychiatric diseases have been discovered as a result of my lab's yeast two-hybrid screens that revealed 28 genes that interact with the C- and N-terminal segments of the GRINL1A Gcom1 protein. Therefore, GRINL1A is no longer an isolated, "esoteric" gene; the Y2H studies have firmly connected it to glutamatergic neurotransmission and transcription and thereby mainstreamed it. Collaborations continue and are flourishing, especially: Jay Yang (U of Wisconsin); Konrad Talbot (Penn); Averell Gnatt (Univ of Maryland at Baltimore).

Distinction: Earlier in my career I co-authored papers in Cell, Molecular and Cellular Biology and Proceedings of the National Academy of Sciences of the USA with Oliver Smithies (and others). In October 2007, Dr. Smithies (and two other scientists) received the Nobel Prize in Physiology or Medicine for his discovery of principles for introducing specific gene modifications into mice using embryonic stem cells.

My Education activities in 2007-2008 added Simulation. I took the Wiser programming course to leqarn how to devise and run scenarios and became part of Dept Sim group. I have done several Sim session with Residents.

Academic: manuscript on the Gcom1-NR1 interaction and inhibition of NMDA toxicity in rat primary cortical neuronal cultures was accepted and has been epubbed (9 October 2008) in NeuroReport. I have two new, first author manuscripts on GCOM1/GRINL1A in preparation and am coauthor on a soon to be submitted invited review article on Anesthetics and Neurotoxicity.

Description of Clinical Expertise

Off-site (out-of-OR) anesthesiology. Anesthesia for spine surgery.
Difficult airway management: courses at ASA Annual meeting and MD Anderson Cancer Center plus daily use of Glidescope and Fiberoptic methods.

Description of Other Expertise

Research training, teaching and mentoring of undergraduate, graduate and medical students, PhD and MD PhD candidates, residents and post-doctoral fellows, at least 25 since the end of my residency (1989) in molecular biology, molecular genetics and genomics.

Selected Publications

Roginski RS, Mohan Raj BK, Sundeep M, Yang J: GRINL1A proteins interact with an NMDA receptor subunit in transfected cells raising the question of in vivo interaction. Society of Neuroanesthesia and Critical Care 2002 Annual Meeting abstract/J Neurosurg Anesthesiol 2002.

Roginski RS, Mohan Raj BK, Birditt B, Rowen L: Hippocampal expression of a human GRINL1A complex transcription unit (CTU) splice variant suggests a role in neuroprotection. American Society of Anesthesiologists 2002 Annual Meeting abstract 2002.

Roginski RS, Mohan Raj BK, Sundeep M, Yang J: Expression of a GRINL1A protein in the presence of an NMDA receptor subunit in transfected cells reveals co-localization in the plasma membrane and raises the question of a possible in vivo interaction. American Society of Anesthesiologists 2002 Annual Meeting abstract 2002.

Roginski RS, Mohan Raj BK, Finkernagel SW, Sciorra LJ: Assignment of an ionotropic glutamate receptor-like gene (GRINL1A) to human chromosome 15q22.1 by in situ hybridization. Cytogenetics and Cell Genetics 93: 143-144, 2001.

Mohan Raj BK, Roginski RS, Finkernagel SW, Sciorra LJ: Assignment of GRINL1B, a glutamate receptor-like processed gene, to human chromosome 4q12 by in situ hybridization. Cytogenetics and Cell Genetics 95: 238-239, 2001.

Wydner KS, Mohan Raj BK, Sciorra, LJ, Roginski RS: The mouse orthologue of the human ionotropic glutamate receptor-like gene (GRINL1A) maps to mouse chromosome 9. Cytogenetics and Cell Genetics 95: 240-241, 2001.

Mohan Raj BK, Roginski RS, Finkernagel SW, Sciorra LJ: Hippocampal expression of human GRINL1A, a new glutamate receptor-like gene. J Neurosurg Anesthesiol 13(4): 363 #31, 2001.

Roginski RS, Mohan Raj BK: Protein expression and exon mining of GRINL1A, a new glutamate receptor-like gene expressed in the human hippocampus. Anesthesiology 95: A777, 2001.

El-Maghrabi EA, Roginski RS, Elnabawi AM, Eldefrawi M, Eckenhoff RG: Effect of volatile anesthetics on glutamate transport. Gordon Research Conference: “Membrane transport proteins.” New London, CT July 2000.

Mohan Raj BK, Roginski RS, Finkernagel SW, Sciorra LJ: Chromosome mapping of a new glutamate receptor gene suggests roles in neuroprotection and autism. J Neurosurg Anesthesiol 12(4): 414 #54, 2000.

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Last updated: 01/24/2012
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