Max Kelz, MD PhDAssistant Professor of Anesthesiology and Critical Care
Member, Penn Genomics Institute, University of Pennsylvania
Member, Mahoney Institute of Neurological Sciences, University of Pennsylvania
Member, Center for Sleep and Respiratory Neurobiology, University of Pennsylvania
Member, Institute for Translational Medicine and Therapeutics
Department: Anesthesiology and Critical Care
Contact information
3620 Hamilton Walk,
John Morgan Building - Room 334 Philadelphia, PA 19104
Office: 215 662-3713
Fax: 215 349-5078 Email: kelzma@uphs.upenn.edu
Graduate Group Affiliations
Links
Max Kelz homepage, Department of Anesthesiology and Critical Care University of Pennsylvania School of Medicine Kelz homepage, Mahoney Institute of Neurological Sciences
Education:
MS (Molecular Biophysics and Biochemistry) Yale University, 1993. BS (Molecular Biophysics and Biochemistry) Yale University, 1993. PhD (Neuroscience) Yale University, 1999. MD (Medicine) Yale University, 2000.
Post-Graduate Training
Intern, University of Pennsylvania, Presbyterian Medical Campus, 2000-2001. Resident , University of Pennsylvania, Department of Anesthesia, 2001-2004.
Certifications
Permanent linkDiplomat, National Board of Medical Examiners, 2001. Diplomat, American Board of Anesthesiology, 2005. Description of Research ExpertiseMolecular Mechanisms of Anesthetic ActionNeurobiology of Sleep Wake Regulation Mouse Genetics Molecular Biology Anesthetic pharmacology Description of Clinical ExpertiseAnesthesiologySelected PublicationsPick Jeremy, Chen Yihan, Moore Jason T, Sun Yi, Wyner Abraham J, Friedman Eliot B, Kelz Max B: Rapid Eye Movement Sleep Debt Accrues in Mice Exposed to Volatile Anesthetics. Anesthesiology 115(4): 702-712, Oct 2011.Friedman EB, Sun Y, Moore JT, Tung H, Meng QC, Perera P, Joiner WJ, Thomas SA, Eckenhoff RG, Sehgal A, Kelz MB: A Conserved Behavioral State Barrier Impedes Transitions between Anesthetic-Induced Unconsciousness and Wakefulness: Evidence for Neural Inertia PLOS ONE 5(7): e11903, July 2010. Bianchi SL, Caltagarone MS, Oddo S, LeFerla FM, Eckenhoff RG, Kelz MB: Inhaled Anesthetic Potency in Aged Alzheimer's Mice. Anesthesia and Analgesia 110: 427-430, Feb 2010 Notes: (Published with an accompanying editorial). Gompf H, Chen J, Sun Y, Yanagisawa M, Aston-Jones G, Kelz MB : Halothane-induced Hypnosis Is Not Accompanied by Inactivation of Orexinergic Output in Rodents Anesthesiology 111(5): 1001-1009, November 2009. Kelz MB, Sun Y, Chen J, Meng QC, Moore JT, Veasey SC, Dixon S, Thornton Ml, Funato H, Yanagisawa M: An Essential Role for Orexins in Emergence from General Anesthesia. Proceedings of the National Academy of Sciences 105(4): 1309-1314, January 2008 Notes: (commentary in PNAS 2008 v.105 p.1100). Zhu Y, Fenik P, Zhan G, Mazza E, Kelz M, Aston-Jones G, Veasey SC: Selective loss of catecholaminergic wake active neurons in a murine sleep apnea model. Journal of Neuroscience 27(37): 10060-71, Sep 2007. Leach NT, Sun Y, Michaud S, Zheng Y, Ligon KL, Ligon AH, Sander T, Korf BR, Lu W, Harris DJ, Gusella JF, Maas RL, Quade BJ, Cole AJ, Kelz MB, Morton CC: Disruption of diacylglycerol kinase delta (DGKD) associated with seizures in humans and mice. American Journal of Human Genetics 80(4): 792-799, April 2007. Sun Y, Chen J, Pruckmayr G, Baumgardner JE, Eckmann DM, Eckenhoff RG, Kelz MB: High throughput modular chambers for rapid evaluation of anesthetic sensitivity. BMC Anesthesiology. Biomed Central, 6(1): 13, November 2006. Zachariou V, Bolanos CA, Selley DE, Theobald D, Cassidy MP, Kelz MB, Shaw-Lutchman T, Berton O, Sim-Selley LJ, Dileone RJ, Kumar A, Nestler EJ: An essential role for DeltaFosB in the nucleus accumbens in morphine action. Nature Neuroscience 9(2): 205-11, Feb 2006. Chen J, Kelz MB, Zeng G, Steffen C, Shockett PE, Terwilliger G, Schatz DG, Nestler EJ: Inducible, reversible hair loss in transgenic mice. Transgenic Research 11(3): 241-7, Jun 2002.
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