Max Kelz, MD PhDAssistant Professor of Anesthesiology and Critical Care
Member, Penn Genomics Institute, University of Pennsylvania
Member, Mahoney Institute of Neurological Sciences, University of Pennsylvania
Member, Center for Sleep and Circadian Neurobiology, University of Pennsylvania
Member, Institute for Translational Medicine and Therapeutics
Department: Anesthesiology and Critical Care
Contact information
3620 Hamilton Walk,
John Morgan Building - Room 334 Philadelphia, PA 19104
Office: 215 662-3713
Fax: 215 349-5078 Email:
kelzma@uphs.upenn.edu
Graduate Group Affiliations
Links
Max Kelz homepage, Department of Anesthesiology and Critical Care University of Pennsylvania School of Medicine Kelz homepage, Mahoney Institute of Neurological Sciences
Education:
BS (Molecular Biophysics and Biochemistry) Yale University, 1993. MS (Molecular Biophysics and Biochemistry) Yale University, 1993. PhD (Neuroscience) Yale University, 1999. MD (Medicine) Yale University, 2000.
Post-Graduate Training
Intern, University of Pennsylvania, Presbyterian Medical Campus, 2000-2001. Resident , University of Pennsylvania, Department of Anesthesia, 2001-2004.
Certifications
Permanent linkDiplomat, National Board of Medical Examiners, 2001. Diplomat, American Board of Anesthesiology, 2005. Description of Research ExpertiseMolecular Mechanisms of Anesthetic ActionNeurobiology of Sleep Wake Regulation Mouse Genetics Molecular Biology Anesthetic pharmacology Description of Clinical ExpertiseAnesthesiologySelected PublicationsKretschmannova K, Hines RM, Revilla-Sanchez R, Terunuma M, Tretter V, Jurd R, Kelz MB, Moss SJ, Davies PA: Enhanced tonic inhibition influences the hypnotic and amnestic actions of the intravenous anesthetics etomidate and propofol. Journal of Neuroscience 33(17): 7264-73, April 2013.Newman J, Blake K, Fennema J, Harris D, Shanks A, Avidan MS, Kelz MB, Mashour GA. : Incidence, risk factors and outcomes of postoperative coma: an observational study of 858,606 patients. European Journal of Anesthesiology 30: 1-7, Jan 2013. Weiser BP, Kelz MB, Eckenhoff RG: In vivo activation of azi-propofol prolongs anesthesia and reveals synaptic targets. J Biol Chem 288(2): 1279-85, Jan 2013. Deutschman CS, Raj NR, McGuire EO, Kelz MB: Orexinergic Activity Modulates Altered Vital Signs and Pituitary Hormone Secretion in Experimental Sepsis. Critical Care Medicine accepted for publication, 2013. McCarren HS, Moore JT, Kelz MB: Assessing changes in volatile general anesthetic sensitivity of mice after local or systemic pharmacological intervention JoVE Accepted for Publication, 2013. Hu FY, Hanna GM, Wei H, Mardini F, Thomas SA, Wyner AJ, Kelz MB: Hypnotic hypersensitivity to volatile anesthetics and dexmedetomidine in dopamine ß-hydroxylase knockout mice. Anesthesiology 117(5): 1006-17, November 2012 Notes: Published with an accompanying an Editorial, Sanders RD and Maze M, Anesthesiology 2012; 117:945-7. Moore JT, Chen J, Han B, Meng Q-C, Veasey SC, Beck SG, Kelz MB: Direct activation of sleep-promoting VLPO neurons by volatile anesthetics contributes to anesthetic hypnosis. Current Biology 22: 2008-16, November 2012 Notes: Published with an editorial by Solt Current Biology 2012 22:R918-9. Publication was the subject of a Nature News and Views http://www.nature.com/nature/journal/v491/n7422/full/491046a.html?WT.ec_id=NATURE-20121101. Li RQ, McKinstry AR, Moore JT, Caltagarone BM, Eckenhoff MF, Eckenhoff RG, Kelz MB: Is hydrogen sulfide induced suspended animation general anesthesia? JPET 341(3): 735-42, June 2012. Pick J, Chen Y, Moore JT, Sun Y, Wyner AJ, Friedman EB, Kelz MB: Rapid eye movement sleep debt accrues in mice exposed to volatile anesthetics. Anesthesiology 115(4): 702-712, Oct 2011 Notes: Accompanied by an editorial: Anesthesiology 2011 115(4)683-4. PMID 21829133. Friedman EB, Sun Y, Moore JT, Tung H, Meng QC, Perera P, Joiner WJ, Thomas SA, Eckenhoff RG, Sehgal A, Kelz MB: A conserved behavioral state barrier impedes transitions between anesthetic-induced unconsciousness and wakefulness: Evidence for neural inertia PLOS ONE 5(7): e11903, July 2010 Notes: Editorial in Science Translational Medicine; http://stm.sciencemag.org.proxy.lib.umich.edu/content/3/98/98ec140.full?sid=860ebb91-6c41-4158-9fe8-8cb38e8d91f6.
|
