Department of Anesthesiology and Critical Care

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David M. Eckmann, PhD, MD

Horatio C. Wood Professor of Anesthesiology and Critical Care
Attending Physician, Department of Anesthesiology & Critical Care, Hospital of the University of Pennsylvania
Member, Institute for Medicine and Engineering, University of Pennsylvania Institute for Medicine and Engineering
Founding Member, Institute for Translational Medicine and Therapeutics, University of Pennsylvania Institute for Translational Medicine and Therapeutics
Member, Cardiovascular Institute, University of Pennsylvania Cardiovascular Institute
Professor of Bioengineering, University of Pennsylvania (Secondary Appointment)
Adjunct Investigator, University of Pennsylvania Institute for Environmental Medicine
Member, University of Pennsylvania Nano/Bio Interface Center
Department: Anesthesiology and Critical Care

Contact information
331 John Morgan Building/6112
3620 Hamilton Walk
Philadelphia, PA 19104-6802
Office: 215-349-5348
Fax: 215-349-5078
B.S. (Bioengineering)
University of California, San Diego, 1983.
Ph.D. (Biomedical Engineering)
Northwestern University, 1989.
M.D. (Medicine)
Northwestern University, 1990.

Medical Scientist Training Program, Northwestern University, 1990.
M.A. (Education (Honorary))
University of Pennsylvania, 2003.
Post-Graduate Training
Fellowship, Center for Multiphase Flow and Transport, School of Engineering, Northwestern University, 1989-1990.
Transitional Year in Medicine, Evanston Hospital, Evanston, Illinois, 1991-1992.
Resident in Anesthesiology, Northwestern University, Chicago, Illinois, 1992-1996.
Diplomate, National Board of Medical Examiners, 1991.
Diplomate, American Board of Anesthesiology, 1997.
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Description of Research Expertise

My current cardiovascular research interests fall into 3 areas:

1. Cellular metabolic engineering. We are examining the relationship between cellular metabolic function and cellular mechanical function. Our goal is to understand mitochondrial function and cellular bioenergetics in the face of cellular mechanical dysfunction and to understand maintenance of cellular mechanical homeostasis when cellular metabolic capacity becomes stressed.

2. Optimization of nanocarrier design for targeted vascular drug delivery. We are using a combination of experimental and computational techniques to assess the influence of design parameters (e.g., carrier type, size, shape, surface density of targeting binding molecules) to optimize carrier binding to vascular endothelium for targeted drug delivery.

3. Biomimetic macromolecular surface grafting for biocompatibility and anti-infectivity of vascular biomaterials. We are making biomimetic surface molecular constructs of biomacromolecules having bioresponsive swelling properties for drug elution. These thin film layers can be grafted onto solid substrates (e.g., vascular stents, grafts, catheters, extracorporeal perfusion circuits) to improve biocompatibility and reduce bioresponses to blood contact to coated biomaterials as well as to resist and respond to bacterial biofilm formation.

Description of Clinical Expertise

Anesthesiology, airway management, regional anesthesia, bariatrics, obesity

Description of Other Expertise

Research continuously funded for over 20 years by NIH, NSF, Department of Defense, NASA and private foundations.

PI of Department's T32 NIH Training Grant

Selected Publications

Kandel, J., Chou, P., Eckmann, D.M.: Automated detection of whole-cell mitochondrial motility and its dependence on cytoarchitectural integrity. Biotechnology & Bioengineering 112(7): 1395-1405, July 2015.

Lee, H.S., Dastgheyb, S.S., Hickok, N.J., Eckmann, D.M.,* Composto, R.J.*: Controlled and localized release of Tobramycin from a stimuli-responsive grafted bilayer challenged with S. aureus. Biomacromolecules 16(2): 650-659, January 2015 Notes: *Equal contributions as senior author.

Coll Ferrer, M.C., Zern, B., Composto, R.J., Muzykantov, V.R., Eckmann, D.M.: ICAM-1 targeted nanogels loaded with dexamethasone alleviate pulmonary inflammation. PLoS ONE 9(7): e102329, July 2014.

Kandel, J., Lee, H.S., Sobolewski, P., Tomczyk, N., Composto, R.J., Eckmann, D.M.: Chemically grafted fibronectin for use in QCM-D cell studies. Biosensors and Bioelectronics 58: 249-257, February 2014.

Lee, H.S., Stachelek, S.J., Tomczyk, N., Composto, R.J., Eckmann, D.M.: Correlating macrophage morphology and cytokine production resulting from biomaterial contact. Journal of Biomedical Materials Research Part A 101(1): 203-212, January 2013.

Coll Ferrer, M.C., Hickok, N.J., Eckmann, D.M., Composto, R.J.: Antibacterial biomimetic hybrid films. Soft Matter 8: 2423-2431, February 2012.

Calderon, A.J., Bhowmick, T., Leferovich, J., Burman, B., Pichette, B., Muzykantov, V.N., Eckmann, D.M.*, Muro, S.*: Optimizing endothelial targeting by modulating the antibody density and particle concentration of anti-ICAM coated carriers. Journal of Controlled Release 150: 37-44, February 2011 Notes: *equal contributions as corresponding authors.

Sobolewski, P., Kandel, J., Klinger, A.L., Eckmann, D.M.: Air bubble contact with endothelial cells in vitro induces calcium influx and IP3-dependent release of calcium stores. American Journal of Physiology - Cell Physiology 301(3): C679-C686, August 2011.

Stachelek, S.J., Finley, M.J., Alferiev, I., Wang, F., Tsai, R., Eckells, E.C., Tomczyk, N., Connolly, J.M., Discher, D.E., Eckmann, D.M., Levy, R.J.: The effect of CD 47 modified polymer surfaces on inflammatory cell attachment and activation. Biomaterials 32: 4317-4326, July 2011.

Liu, J., Weller, G.E.R., Zern, B., Ayyaswamy, P.S., Eckmann, D.M., Muzykantov, V., Radhakrishnan, R.: A computational model for nanocarrier binding to endothelium validated using in vivo, in vitro, and Atomic Force Microscopy experiments. Proceedings of the National Academy of Sciences 107(38): 16530-16535, September 2010.

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Last updated: 11/05/2015
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