Department of Anesthesiology and Critical Care

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David M. Eckmann, PhD, MD

Horatio C. Wood Professor of Anesthesiology and Critical Care
Attending Physician, Department of Anesthesiology & Critical Care, Hospital of the University of Pennsylvania
Member, Institute for Medicine and Engineering, University of Pennsylvania Institute for Medicine and Engineering
Founding Member, Institute for Translational Medicine and Therapeutics, University of Pennsylvania Institute for Translational Medicine and Therapeutics
Member, Cardiovascular Institute, University of Pennsylvania Cardiovascular Institute
Professor of Bioengineering, University of Pennsylvania (Secondary Appointment)
Adjunct Investigator, University of Pennsylvania Institute for Environmental Medicine
Member, University of Pennsylvania Nano/Bio Interface Center
Department: Anesthesiology and Critical Care

Contact information
331 John Morgan Building/6112
3620 Hamilton Walk
Philadelphia, PA 19104-6802
Office: 215-349-5348
Fax: 215-349-5078
Education:
B.S. (Bioengineering)
University of California, San Diego, 1983.
Ph.D. (Biomedical Engineering)
Northwestern University, 1989.
M.D. (Medicine)
Northwestern University, 1990.

Medical Scientist Training Program, Northwestern University, 1990.
M.A. (Education (Honorary))
University of Pennsylvania, 2003.
Post-Graduate Training
Fellowship, Center for Multiphase Flow and Transport, School of Engineering, Northwestern University, 1989-1990.
Transitional Year in Medicine, Evanston Hospital, Evanston, Illinois, 1991-1992.
Resident in Anesthesiology, Northwestern University, Chicago, Illinois, 1992-1996.
Certifications
Diplomate, National Board of Medical Examiners, 1991.
Diplomate, American Board of Anesthesiology, 1997.
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Description of Research Expertise

Interfacial fluid mechanics, bioenergetics, biofluid mechanics, biological fluid dynamics, vascular biology, cardiovascular physiology, surfactant, gas embolism, air embolism, cellular mechanics, computational fluid dynamics, surface tension, bubbles, biomaterials, biomimetic materials, surface adsorption, surface grafting, bioengineering, biomedical engineering, targeted drug delivery, nanocarriers, ICAM-1

Description of Clinical Expertise

Anesthesiology, airway management, regional anesthesia, bariatrics, obesity

Selected Publications

Lee, H.S., Stachelek, S.J., Tomczyk, N., Composto, R.J., Eckmann, D.M.: Correlating macrophage morphology and cytokine production resulting from biomaterial contact. Journal of Biomedical Materials Research Part A 101(1): 203-212, January 2013.

Sobolewski, P., Kandel, J., Eckmann, D.M.: Air bubble contact with endothelial cells causes a calcium-independent loss in mitochondrial membrane potential. PLoS ONE 7(10): e47254, October 2012.

Lee, H.S., Yee, M.Q., Eckmann, Y.Y., Hickok, N.J., Eckmann, D.M., Composto, R.J.: Tuning the swelling of chitosan brushes by varying quaternary ammonium salt content and counterion type. Journal of Materials Chemistry 22: 19605-19616, September 2012.

Coll Ferrer, M.C., Hickok, N.J., Eckmann, D.M., Composto, R.J.: Antibacterial biomimetic hybrid films. Soft Matter 8: 2423-2431, February 2012.

Calderon, A.J., Bhowmick, T., Leferovich, J., Burman, B., Pichette, B., Muzykantov, V.N., Eckmann, D.M.*, Muro, S.*: Optimizing endothelial targeting by modulating the antibody density and particle concentration of anti-ICAM coated carriers. Journal of Controlled Release 150: 37-44, February 2011 Notes: *equal contributions as corresponding authors.

Liu, J., Agrawal, N.J., Calderon, A.J., Ayyaswamy, P.S., Eckmann, D.M., Radhakrishnan, R.: Multivalent nature of nanocarrier binding to endothelial cells is sufficient to induce flow enhanced binding behavior in shear flow. Biophysical Journal 101(2): 319-326, July 2011 Notes: Selected as Cover Article.

Sobolewski, P., Kandel, J., Klinger, A.L., Eckmann, D.M.: Air bubble contact with endothelial cells in vitro induces calcium influx and IP3-dependent release of calcium stores. American Journal of Physiology - Cell Physiology 301(3): C679-C686, August 2011.

Liao, Z.Z., Lampe, J.W., Ayyaswamy, P.S., Eckmann, D.M.*, Dmochowski, I.J.*: Protein assembly at the air-water interface studied by confocal microscopy. Langmuir 27: 12775–12781, September 2011 Notes: *equal contributions as corresponding authors.

Stachelek, S.J., Finley, M.J., Alferiev, I., Wang, F., Tsai, R., Eckells, E.C., Tomczyk, N., Connolly, J.M., Discher, D.E., Eckmann, D.M., Levy, R.J.: The effect of CD 47 modified polymer surfaces on inflammatory cell attachment and activation. Biomaterials 32: 4317-4326, July 2011.

Klinger, A.L., Pichette, B., Sobolewski, P., Eckmann, D.M.: Mechanotransductional basis of endothelial cell response to intravascular bubble contact. Integrative Biology 3: 1033-1042, October 2011.

Liu, J., Weller, G.E.R., Zern, B., Ayyaswamy, P.S., Eckmann, D.M., Muzykantov, V., Radhakrishnan, R.: A computational model for nanocarrier binding to endothelium validated using in vivo, in vitro, and Atomic Force Microscopy experiments. Proceedings of the National Academy of Sciences 107(38): 16530-16535, September 2010.

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Last updated: 11/13/2014
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